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Current Pediatric Reviews


ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Single Nucleotide Polymorphisms in Neonatal Necrotizing Enterocolitis

Author(s): Keyur T. Donda*, Benjamin A. Torres, Minesh Khashu and Akhil Maheshwari

Volume 18, Issue 3, 2022

Published on: 18 March, 2022

Page: [197 - 209] Pages: 13

DOI: 10.2174/1573396318666220117091621

Price: $65


The etiopathogenesis of necrotizing enterocolitis (NEC) remains unclear, but increasing information suggests that the risk and severity of NEC may be influenced by single nucleotide polymorphisms in many genes. In this article, we have reviewed gene variations that have either been specifically identified in NEC or have been noted in other inflammatory bowel disorders with similar histopathological abnormalities. We present evidence from our own peer-reviewed laboratory studies and data from an extensive literature search in the databases PubMed, EMBASE, and Scopus. To avoid bias in the identification of existing studies, search keywords were short-listed both from our own studies and from PubMed’s Medical Subject Heading (MeSH) thesaurus.

Keywords: Single nucleotide polymorphism, necrotizing enterocolitis, neonates, genetic predisposition, spontaneous intestinal perforation, inherited disease.

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