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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Ferroptosis Inducers for Prostate Cancer Therapy

Author(s): Nadia Zaffaroni and Giovanni Luca Beretta*

Volume 29, Issue 24, 2022

Published on: 03 February, 2022

Page: [4185 - 4201] Pages: 17

DOI: 10.2174/0929867329666220111120924

Price: $65

Abstract

Lipid peroxidation-driven iron-dependent ferroptosis is a regulated cell death mechanism implicated in numerous diseases, such as neurological diseases, kidney injury, ischemia, and tumors, including prostate cancer. The cellular mechanisms of ferroptosis are strongly associated with iron, reactive oxygen species and amino acid metabolic pathways. Several compounds, namely ferroptosis inducers, impact these pathways and trigger ferroptosis by i) inhibiting Xc - transporter system, ii) impairing GPX4 functions and iii) oxidizing iron and polyunsaturated phospholipids. Preclinical studies show that in combination with conventional anticancer drugs, ferroptosis inducers are effective in prostate cancer and in combating the progression towards the castration-resistant disease. This review overviews the mechanisms implicated in ferroptosis and discusses the findings achieved in prostate cancer.

Keywords: Prostate cancer, ferroptosis, lipid peroxidation, GPX4, ROS, cancer therapy.


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