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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

肿瘤微环境在肿瘤干细胞抗放疗中的影响

卷 22, 期 1, 2022

发表于: 31 January, 2022

页: [18 - 30] 页: 13

弟呕挨: 10.2174/1568009622666211224154952

价格: $65

摘要

癌症是一种慢性疾病，涉及肿瘤和宿主基质细胞的多种成分。目前，肿瘤微环境（TME）中存在的各种因素与肿瘤细胞以及位于TME内的免疫细胞之间的复杂关系仍知之甚少。在 TME 内，这些因素和免疫细胞的串扰从根本上决定了肿瘤对治疗的反应以及肿瘤最终如何被破坏、保持休眠或发展和转移。此外，在 TME 中，癌症相关成纤维细胞 (CAF)、细胞外基质 (ECM)、缺氧诱导因子 (HIF) 之间的相互串扰增强了癌症干细胞 (CSC) 的增殖能力。 CSC 是位于肿瘤块内的细胞亚群，具有自我更新、分化和修复 DNA 损伤的能力。这些特性使 CSC 对各种治疗产生耐药性，例如放疗 (RT)。 RT 是一种常见且经常治愈的局部癌症治疗方法，它通过细胞毒性作用介导肿瘤消除。此外，释放到 TME 中的细胞因子和生长因子参与了肿瘤放射抗性的激活和不同免疫细胞的诱导，从而改变了局部免疫反应。在这篇综述中，我们讨论了 TME 在 CSCs 对 RT 的抵抗中的关键作用。

关键词: 放疗、肿瘤干细胞、肿瘤微环境、肿瘤相关成纤维细胞、细胞外基质、缺氧诱导因子

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