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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Potential Roles of α-amylase in Alzheimer’s Disease: Biomarker and Drug Target

Author(s): Win Ning Chen, Kim San Tang and Keng Yoon Yeong*

Volume 20, Issue 8, 2022

Published on: 12 April, 2022

Page: [1554 - 1563] Pages: 10

DOI: 10.2174/1570159X20666211223124715

Price: $65


Alzheimer’s disease (AD), the most common form of dementia, is pathologically characterized by the deposition of amyloid-β plaques and the formation of neurofibrillary tangles. In a neurodegenerative brain, glucose metabolism is also impaired and considered as one of the key features in AD patients. The impairment causes a reduction in glucose transporters and the uptake of glucose as well as alterations in the specific activity of glycolytic enzymes. Recently, it has been reported that α-amylase, a polysaccharide-degrading enzyme, is present in the human brain. The enzyme is known to be associated with various diseases such as type 2 diabetes mellitus and hyperamylasaemia. With this information at hand, we hypothesize that α-amylase could have a vital role in the demented brains of AD patients. This review aims to shed insight into the possible link between the expression levels of α-amylase and AD. Lastly, we also cover the diverse role of amylase inhibitors and how they could serve as a therapeutic agent to manage or stop AD progression.

Keywords: Alzheimer’s disease, biomarker, drug target, alpha-amylase, enzyme inhibitor, amyloid-beta, neurological disorders, drug repurposing.

Graphical Abstract
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