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Current Medical Imaging


ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Case Report

Anti-synthetase Syndrome Complicated by Pyogenic Myositis

Author(s): David Lizarazo, Karen Cifuentes , Paula Andrea Forero* and Hernan Páez

Volume 18, Issue 7, 2022

Published on: 01 March, 2022

Article ID: e221221199294 Pages: 4

DOI: 10.2174/1573405618666211222161022

Price: $65


Background: Anti-synthetase syndrome is a rare autoimmune disorder characterized by autoantibodies against aminoacyl-tRNA-synthetases. Inflammatory myopathy and interstitial lung disease could be present among other manifestations. Anti-Jo-1 is the most common antisynthetase antibody and is the most likely to present with the classic triad (interstitial lung disease, myositis, and arthritis), and includes more muscle and joint involvement than patients with other antisynthetase antibodies.

Case Report: Here, we present a case of a 60-year-old female patient with a previous diagnosis of myositis, secondary to the anti-synthetase syndrome, a complication of pyogenic myositis.

Conclusion: The diagnosis of anti-synthetase syndrome is made by a multidisciplinary approach, and occasionally, muscle and/or lung biopsy is needed. Imaging studies, especially magnetic resonance imaging, based on findings such as muscle and fascial edema, and fatty tissue replacement, allow an optimal approach.

Keywords: Anti-synthetase syndrome, pyogenic myositis, musculoskeletal imaging, interstitial lung disease, arthritis, biopsy.

Graphical Abstract
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