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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181


Potential Protective Effect of Dl-3-n-butylphthalide on Chronic Cerebral Ischemia Brain Injury

Author(s): Fangfang Zhao and Yumin Luo*

Volume 21, Issue 9, 2022

Published on: 01 February, 2022

Page: [734 - 737] Pages: 4

DOI: 10.2174/1871527321666211221160922


Chronic cerebral ischemia is one of the common ischemic cerebrovascular diseases. Chronic cerebral ischemia can lead to brain dysfunction, and its pathophysiological mechanism involves inflammation, blood-brain barrier destruction, oxidative stress, and other factors. As it is difficult to detect, it is easily overlooked, and it is often only observed following the onset of cognitive dysfunction. At present, there are only a few drugs for its treatment. Dl-3-n-butylphthalide (NBP), a compound extracted from celery seed, may play an important role in protecting against brain damage caused by chronic cerebral ischemia. Therefore, here, we have paid attention to the prevention and treatment of chronic cerebral ischemia with NBP.

Keywords: Chronic cerebral ischemia, NBP, brain damage, inflammation, blood-brain barrier destruction, oxidative stress.

Graphical Abstract
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