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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Nanoparticles Mediated Target-specific Drug Delivery in Prostate Cancer: An In-depth Review

Author(s): Tarun Kumar Upadhyay*, Mohammed Irfan Ali, Fahad Khan, Harsh Goel, Manas Mathur, Keshav Goyal, Sarmad Moin, Pratibha Pandey, Pranay Tanwar, Amit Baran Sharangi, Saloni Dinesh Chandra Gautam, Jhanvi Kiran Kapdi, Kruti Indravadan Patel, Meghna Vipulbhai Patel, Amisha M. Parmar and Mohammad Amjad Kamal

Volume 29, Issue 24, 2022

Published on: 26 January, 2022

Page: [4170 - 4184] Pages: 15

DOI: 10.2174/0929867329666211221112312

Price: $65


Nanotechnology has been extensively exploited for its enormous therapeutic and diagnostic potential in the management of multiple disorders. It employs nanomaterials as drug carriers with enhanced efficacy and limited side effects on normal tissues. A lot of nanomaterials have been studied and produced, imminently reforming the treatment and diagnostics of numerous malignancies, including cancer. The purpose of the present study is to explore the role of nanotechnology-based devices/therapies that have a vital function in the therapeutics and diagnostics of cancer with potential impact at three levels: early detection, tumor imaging, and drug delivery methods. Concentrating on cancer, promising nanotechnology-based approaches have been planned to satisfy the need for targeted specificity of traditional agents of chemotherapeutics, in addition to early recognition of malignant and precancerous lesions. Prostate cancer is the fifth most wellknown cancer worldwide and the second most usually detected cancer in men. Therefore, there is a crucial need to improve therapeutic prospects for the diagnosis and treatment of prostate cancer via the exploitation of the potential of nanomaterials for cell-targeted specificity and improved primary diagnosis of precancerous tumors. The present review, therefore, focuses on summarizing all prospective applications of nanotechnology in the prognosis and diagnosis of prostate cancer, which would further help researchers to elucidate a more potent therapeutic approach for the better management of prostate cancer in the days ahead.

Keywords: Cancer cell, prostate cancer, cytotoxicity, nanoparticles, targeted delivery, drug delivery.

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