摘要
痴呆症是一种由慢性或进行性脑部疾病引起的综合征。 全球约 40% 的痴呆症可以通过改变 12 个风险因素来预防或延缓:早年教育程度低、中年高血压、中年肥胖、听力损失、脑外伤、过度饮酒、吸烟、抑郁、身体 不活动、社会孤立、糖尿病和空气污染。 越来越多的证据表明,胃肠道微生物群可能显着促进痴呆症的发病机制。 特别是,肠道菌群失调会引发代谢疾病和低度全身炎症的进展,与许多主要的可改变风险因素有关。 在这篇综述中,我们重点关注评估痴呆的可改变危险因素与肠道微生物群作用之间关联的研究。 我们还建议对痴呆-肠道微生物群相关领域的研究人员的临床意义。
关键词: 痴呆症、危险因素、肠道微生物群、生态失调、生活方式、预防。
Current Alzheimer Research
Title:Modifiable Risk Factors for Dementia: The Role of Gut Microbiota
Volume: 18 Issue: 13
关键词: 痴呆症、危险因素、肠道微生物群、生态失调、生活方式、预防。
摘要: Dementia is a syndrome resulting from chronic or progressive brain disease. Around 40% of worldwide dementia can be prevented or delayed by modifying 12 risk factors: low educational attainment in early life, mid-life hypertension, mid-life obesity, hearing loss, traumatic brain injury, excessive alcohol consumption, smoking, depression, physical inactivity, social isolation, diabetes mellitus, and air pollution. There is growing evidence that gastrointestinal tract microbiota may significantly contribute to dementia pathogenesis. In particular, gut dysbiosis can trigger metabolic diseases and the progression of low-grade systemic inflammation, being involved in much of the major modifiable risk factors. In this review, we focus on studies that have evaluated the association between modifiable risk factors for dementia and the role of gut microbiota. We also suggest clinical implications for researchers in dementia-gut microbiota related fields.
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Cite this article as:
Modifiable Risk Factors for Dementia: The Role of Gut Microbiota, Current Alzheimer Research 2021; 18 (13) . https://dx.doi.org/10.2174/1567205018666211215152411
DOI https://dx.doi.org/10.2174/1567205018666211215152411 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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