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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

The Emerging Role of Epigenetic Methylation in Kidney Disease

Author(s): Li Wen, Hong-liu Yang, Lin Lin, Liang Ma* and Ping Fu

Volume 29, Issue 21, 2022

Published on: 31 January, 2022

Page: [3732 - 3747] Pages: 16

DOI: 10.2174/1573405617666211213110222

Price: $65


Kidney disease has complex and multifactorial pathophysiology and pathogenesis. Recent studies have revealed that epigenetic methylation changes, namely DNA methylation, histone methylation and non-histone methylation, are strongly implicated in various forms of kidney diseases. This review provides a perspective on the emerging role of epigenetic methylation in kidney disease, including the effects of DNA methylation in diverse promoter regions, regulation and implication of histone methylation, and recent advances and potential directions related to non-histone methylation. Monitoring or targeting epigenetic methylation has the potential to contribute to development of therapeutic approaches for multiple kidney diseases.

Keywords: Epigenomics, DNA methylation, histones, non-histone, methylation, kidney diseases.

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Waldmann, T.; Izzo, A.; Kamieniarz, K.; Richter, F.; Vogler, C.; Sarg, B.; Lindner, H.; Young, N.L.; Mittler, G.; Garcia, B.A.; Schneider, R. Methylation of H2AR29 is a novel repressive PRMT6 target. Epigenetics Chromatin, 2011, 4(1), 11.
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Mersaoui, S.Y.; Yu, Z.; Coulombe, Y.; Karam, M.; Busatto, F.F.; Masson, J-Y.; Richard, S. Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids. EMBO J., 2019, 38(15)e100986
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