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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Selected Natural and Synthetic Agents Effective against Parkinson’s Disease with Diverse Mechanisms

Author(s): Hayrettin Ozan Gulcan*

Volume 22, Issue 3, 2022

Published on: 14 December, 2021

Page: [199 - 208] Pages: 10

DOI: 10.2174/1568026621666211129141316

Price: $65

Abstract

Similar to other neurodegenerative diseases, Parkinson’s disease (PD) has been extensively investigated with respect to its neuropathological background and possible treatment options. Since the symptomatic outcomes are generally related to dopamine deficiency, the current treatment strategies towards PD mainly employ dopaminergic agonists as well as the compounds acting on dopamine metabolism. These drugs do not provide disease modifying properties; therefore alternative drug discovery studies focus on targets involved in the progressive neurodegenerative character of PD. This study has aimed to present the pathophysiology of PD concomitant to the representation of drugs and promising molecules displaying activity against the validated and non-validated targets of PD.

Keywords: Parkinson’s disease, Dopaminergic agonists, α-synuclein, MAO-B inhibitors, COMT inhibitors, Natural products.

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