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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Update on the Biological Relevance of Lysine Acetylation as a Novel Drug Target in Trypanosomatids

Author(s): Gonzalo Martinez Peralta, Esteban Serra* and Victoria Lucia Alonso*

Volume 29, Issue 20, 2022

Published on: 15 March, 2022

Page: [3638 - 3659] Pages: 22

DOI: 10.2174/0929867328666211126145721

Price: $65

Abstract

The number of acetylated proteins identified from bacteria to mammals has grown exponentially in the last ten years, and it is now accepted that acetylation is a key component in most eukaryotic signaling pathways and is as important as phosphorylation. The enzymes involved in this process are well described in mammals; acetyltransferases and deacetylases are found inside and outside the nuclear compartment and have different regulatory functions. In trypanosomatids, several of these enzymes have been described and are postulated to be novel antiparasitic targets for the rational design of drugs. In this review article, we present an update of the most important known acetylated proteins in trypanosomatids, analyzing the acetylomes available. Also, we summarize the information available regarding acetyltransferases and deacetylases in trypanosomes and their potential use as chemotherapeutic targets.

Keywords: Acetylation, acetyltransferases, deacetylases, acetylome, trypanosomatids, cytoskeleton.

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