Recent Advances in Biotransformation by Cunninghamella Species

Title:Recent Advances in Biotransformation by Cunninghamella Species

Volume: 22 Issue: 13

Author(s): Manoela Daiele Gonçalves*, Fernanda Tomiotto-Pellissier, Ricardo Luís Nascimento de Matos, João Paulo Assolini, Bruna Taciane da Silva Bortoleti, Virginia Marcia Concato, Taylon Felipe Silva, Janice Aparecida Rafael, Wander Rogério Pavanelli, Ivete Conchon-Costa and Nilton Syogo Arakawa

Affiliation:

• Laboratory of Biotransformation and Phytochemistry, Department of Chemistry, Center of Exact Sciences and Department of Pharmaceutical Sciences, Center of Health Sciences, State University of Londrina,Brazil

Keywords: Filamentous fungi, metabolism, chemical modifications, green chemical, cytochrome P450, xenobiotics.

Abstract: The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp. is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.

Cite this article as:

Gonçalves Daiele Manoela *, Tomiotto-Pellissier Fernanda , de Matos Luís Nascimento Ricardo, Assolini Paulo João , da Silva Bortoleti Taciane Bruna, Concato Marcia Virginia, Silva Felipe Taylon , Rafael Aparecida Janice, Pavanelli Rogério Wander , Conchon-Costa Ivete and Arakawa Syogo Nilton , Recent Advances in Biotransformation by Cunninghamella Species, Current Drug Metabolism 2021; 22 (13) . https://dx.doi.org/10.2174/1389200222666211126100023