Login Register Cart 0
Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

In vivo Acute Anti-Inflammatory Activity of Essential Oils: A Review

Author(s): Letícia Groli Lucca, Pedro Roosevelt Torres Romão, Márcia Vignoli-Silva, Valdir F. da Veiga-Junior and Letícia S. Koester*

Volume 22, Issue 11, 2022

Published on: 14 January, 2022

Page: [1495 - 1515] Pages: 21

DOI: 10.2174/1389557521666211123091541

Price: $65

Abstract

In recent years, there has been a significant increase in the search for new therapeutic strategies for the treatment of inflammatory diseases. In this sense, natural products emerge as a potential source for the discovery of new drugs, with the research of the pharmacological properties of these products being very important. In addition to its function in plants (insect attraction and repellency), essential oils present pharmacological effects, such as antibacterial, antifungal, antimutagenic, antiviral, antiprotozoal, antioxidant, antidiabetic and anti-inflammatory properties. In this review, we describe the mostly used in vivo acute inflammatory experimental models and the studies showing the in vivo anti-inflammatory activity of essential oils. Essential oil from species from the Apiaceae, Asteraceae, Burseraceae, Boraginaceae, Cupressaceae, Euphorbiaceae, Fabaceae, Lamiaceae, Lauraceae, Myrtaceae, Piperaceae, Poaceae, Rutaceae, Verbenaceae and Zingiberaceae families were described as being anti-inflammatory in vivo. Five models of acute inflammation are commonly used to investigate the anti-inflammatory activity in vivo: ear and paw edema, pleurisy, peritonitis and the subcutaneous air pouch model. In addition to in vivo analysis, ex vivo and in vitro experiments are carried out to study the anti-inflammatory action of essential oils. The most commonly used model was paw edema, especially due to this model being easy to perform. In order to suggest or elucidate the mechanisms involved in the anti-inflammatory effect, many studies measured some inflammatory mediators, such as cytokines, COX-2 expression and the levels of PGE2, and NO, or evaluated the effect of essential oils or their major compounds on inflammation response directly induced by inflammatory mediators

Keywords: Plants, terpenes, acute inflammation, edema, pleurisy, peritonitis, air pouch, inflammatory mediators.

« Previous Next »
Graphical Abstract

[1]
Lenardão, E.J.; Savegnago, L.; Jacob, R.G.; Victoria, F.N. Antinociceptive effect of essential oils and their constituents: An update review. J. Braz. Chem. Soc., 2016, 27(3), 435-474.
[2]
Sangwan, N.S.; Farooqi, A.H.A.; Shabih, F.; Sangwan, R.S. Regulation of essential oil production in plants. Plant Growth Regul., 2001, 34(1), 3-21.
[http://dx.doi.org/10.1023/A:1013386921596]
[3]
Nakatsu, T.; Lupo, A.T.; Chinn, J.W.; Kang, R.K.L. Biological activity of essential oils and their constituents. In: Studies in Natural Products Chemistry; Atta-ur-Rahman, , Ed.; Elsevier: Amsterdam, 2000; 21, pp. 571-631.
[http://dx.doi.org/10.1016/S1572-5995(00)80014-9]
[4]
Evans, W.C. Volatile Oils and Resins. In: Trease and Evans Pharmacognosy; Evans, W., Ed.; Saunders Elsevier: Edinburgh, 2009, p. 603.
[http://dx.doi.org/10.1016/B978-0-7020-2933-2.00022-8]
[5]
Bakkali, F.; Averbeck, S.; Averbeck, D.; Idaomar, M. Biological effects of essential oils--a review. Food Chem. Toxicol., 2008, 46(2), 446-475.
[http://dx.doi.org/10.1016/j.fct.2007.09.106] [PMID: 17996351]
[6]
Guenther, E. History-Origin in Plants Production-Analysis3rd ed; The Essential OilsRobert E. Krieger Publishing Company: Toronto,; , 1948.
[7]
Bruneton, J. Pharmacognosie, 4th ed; Tec & Doc: Paris, 2009.
[8]
Raut, J.S.; Karuppayil, S.M. A status review on the medicinal properties of essential oils. Ind. Crops Prod., 2014, 62, 250-264.
[http://dx.doi.org/10.1016/j.indcrop.2014.05.055]
[9]
Burt, S. Essential oils: Their antibacterial properties and potential applications in foods-A review. Int. J. Food Microbiol., 2004, 94(3), 223-253.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2004.03.022] [PMID: 15246235]
[10]
Edris, A.E. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: A review. Phytother. Res., 2007, 21(4), 308-323.
[http://dx.doi.org/10.1002/ptr.2072] [PMID: 17199238]
[11]
Adorjan, B.; Buchbauer, G. Biological properties of essential oils: An updated review. Flavour Fragrance J., 2010, 25(6), 407-426.
[http://dx.doi.org/10.1002/ffj.2024]
[12]
Aharoni, A.; Jongsma, M.A.; Kim, T-Y.; Ri, M-B.; Giri, A.P.; Verstappen, F.W.A.; Schwab, W.; Bouwmeester, H.J. Metabolic engineering of terpenoid biosynthesis in plants. Phytochem. Rev., 2006, 5(1), 49-58.
[http://dx.doi.org/10.1007/s11101-005-3747-3]
[13]
Yadav, N.; Yadav, R.; Goyal, A. Chemistry of terpenoids. Int. J. Pharm. Sci. Rev. Res., 2014, 27(45), 272-278.
[14]
Kamatou, G.P.P.; Viljoen, A.M. A review of the application and pharmacological properties of Alpha-Bisabolol and Alpha-Bisabolol-rich oils. J. Am. Oil Chem. Soc., 2010, 87(1), 1-7.
[http://dx.doi.org/10.1007/s11746-009-1483-3] [PMID: 21350591]
[15]
Gershenzon, J.; Dudareva, N. The function of terpene natural products in the natural world. Nat. Chem. Biol., 2007, 3(7), 408-414.
[http://dx.doi.org/10.1038/nchembio.2007.5] [PMID: 17576428]
[16]
Medzhitov, R. Inflammation 2010: New adventures of an old flame. Cell, 2010, 140(6), 771-776.
[http://dx.doi.org/10.1016/j.cell.2010.03.006] [PMID: 20303867]
[17]
Fullerton, J.N.; Gilroy, D.W. Resolution of inflammation: A new therapeutic frontier. Nat. Rev. Drug Discov., 2016, 15(8), 551-567.
[http://dx.doi.org/10.1038/nrd.2016.39] [PMID: 27020098]
[18]
Feehan, K.T.; Gilroy, D.W. Is resolution the end of inflammation? Trends Mol. Med., 2019, 25(3), 198-214.
[http://dx.doi.org/10.1016/j.molmed.2019.01.006] [PMID: 30795972]
[19]
Sugimoto, M.A.; Vago, J.P.; Perretti, M.; Teixeira, M.M. Mediators of the resolution of the inflammatory response. Trends Immunol., 2019, 40(3), 212-227.
[http://dx.doi.org/10.1016/j.it.2019.01.007] [PMID: 30772190]
[20]
Posadas, I.; Bucci, M.; Roviezzo, F.; Rossi, A.; Parente, L.; Sautebin, L.; Cirino, G. Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Br. J. Pharmacol., 2004, 142(2), 331-338.
[http://dx.doi.org/10.1038/sj.bjp.0705650] [PMID: 15155540]
[21]
Winyard, P.G.; Willoughby, D.A. Inflammation Protocols; Humana Press: New Jersey, 2003, Vol. 225, .
[http://dx.doi.org/10.1385/1592593747]
[22]
Tubaro, A.; Dri, P.; Delbello, G.; Zilli, C.; Della Loggia, R. The croton oil ear test revisited. Agents Actions, 1986, 17(3-4), 347-349.
[http://dx.doi.org/10.1007/BF01982641] [PMID: 3962781]
[23]
Carlson, R.P.; O’Neill-Davis, L.; Chang, J.; Lewis, A.J. Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents. Agents Actions, 1985, 17(2), 197-204.
[http://dx.doi.org/10.1007/BF01966592] [PMID: 3938181]
[24]
Ishii, K.; Motoyoshi, S.; Kawata, J.; Nakagawa, H.; Takeyama, K. A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. Jpn. J. Pharmacol., 1994, 65(4), 297-303.
[http://dx.doi.org/10.1254/jjp.65.297] [PMID: 7990266]
[25]
Blazsó, G.; Gábor, M. Effects of prostaglandin antagonist phloretin derivatives on mouse ear edema induced with different skin irritants. Prostaglandins, 1995, 50(3), 161-168.
[http://dx.doi.org/10.1016/0090-6980(95)00109-3] [PMID: 8750212]
[26]
Kolaczkowska, E.; Seljelid, R.; Plytycz, B. Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice. J. Leukoc. Biol., 2001, 69(1), 33-42.
[PMID: 11200065]
[27]
Serhan, C.N.; Ward, P.A.; Gilroy, D.W., Eds.; Fundamentals of Inflammation, 1st ed; Cambridge University Press: New York, 2010.
[http://dx.doi.org/10.1017/CBO9781139195737]
[28]
Sedgwick, A.D.; Lees, P. A comparison of air pouch, sponge and pleurisy models of acute carrageenan inflammation in the rat. Agents Actions, 1986, 18(3-4), 439-446.
[http://dx.doi.org/10.1007/BF01965009] [PMID: 3463171]
[29]
Utsunomiya, I.; Ito, M.; Oh-ishi, S. Generation of inflammatory cytokines in zymosan-induced pleurisy in rats: TNF induces IL-6 and cytokine-induced neutrophil chemoattractant (CINC) in vivo. Cytokine, 1998, 10(12), 956-963.
[http://dx.doi.org/10.1006/cyto.1998.0376] [PMID: 10049519]
[30]
Duarte, D.B.; Vasko, M.R.; Fehrenbacher, J.C. Models of inflammation: Carrageenan air pouch. Curr. Protocols Pharmacol., 2012, 56, 1-9.
[http://dx.doi.org/10.1002/0471141755.ph0506s56]
[31]
Wang, C.; Sun, J.; Li, H.; Yang, X.; Liu, H.; Chen, J. In vivo anti-inflammatory activities of the essential oil from Radix Angelicae dahuri-cae. J. Nat. Med., 2016, 70(3), 563-570.
[http://dx.doi.org/10.1007/s11418-016-0978-0] [PMID: 26906120]
[32]
Yao, W.; Zhang, L.; Hua, Y.; Ji, P.; Li, P.; Li, J.; Zhong, L.; Zhao, H.; Wei, Y. The investigation of anti-inflammatory activity of volatile oil of Angelica sinensis by plasma metabolomics approach. Int. Immunopharmacol., 2015, 29(2), 269-277.
[http://dx.doi.org/10.1016/j.intimp.2015.11.006] [PMID: 26578286]
[33]
Li, J.; Hua, Y.; Ji, P.; Yao, W.; Zhao, H.; Zhong, L.; Wei, Y. Effects of volatile oils of Angelica sinensis on an acute inflammation rat mo-del. Pharm. Biol., 2016, 54(9), 1881-1890.
[http://dx.doi.org/10.3109/13880209.2015.1133660] [PMID: 26853745]
[34]
Zhong, L.J.; Hua, Y.L.; Ji, P.; Yao, W.L.; Zhang, W.Q.; Li, J.; Wei, Y.M. Evaluation of the anti-inflammatory effects of volatile oils from processed products of Angelica sinensis radix by GC-MS-based metabolomics. J. Ethnopharmacol., 2016, 191, 195-205.
[http://dx.doi.org/10.1016/j.jep.2016.06.027] [PMID: 27292195]
[35]
Hajhashemi, V.; Sajjadi, S.E.; Heshmati, M. Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroal-coholic extract in animal models. J. Ethnopharmacol., 2009, 124(3), 475-480.
[http://dx.doi.org/10.1016/j.jep.2009.05.012] [PMID: 19467316]
[36]
Leite, G. de O.; Leite, L.H.I.; Sampaio, R. de S.; Araruna, M.K.A.; Rodrigues, F.F.G.; de Menezes, I.R.A.; da Costa, J.G.M.; Campos, A.R. Modulation of topical inflammation and visceral nociception by Vanillosmopsis arborea essential oil in mice. Biomed. Prev. Nutr., 2011, 1(3), 216-222.
[http://dx.doi.org/10.1016/j.bionut.2011.06.001]
[37]
Li, X-J. Yang, Y.J.; Li, Y.S.; Zhang, W.K.; Tang, H.B. -Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. J. Ethnopharmacol., 2016, 179, 22-26.
[http://dx.doi.org/10.1016/j.jep.2015.12.039] [PMID: 26721216]
[38]
Siani, A.C.; Ribeiro-dos-santos, R.; Fernadez-ferreira, E.; Rosas, E.C.; Susunaga, G.S.; Guimara, A.C. Evaluation of anti-in ammatory-related activity of essential oils from the leaves and resin of species of protium. J. Ethnopharmacol., 1999, 66, 57-69.
[http://dx.doi.org/10.1016/S0378-8741(98)00148-2] [PMID: 10432208]
[39]
Passos, G.F.; Fernandes, E.S.; da Cunha, F.M.; Ferreira, J.; Pianowski, L.F.; Campos, M.M.; Calixto, J.B. Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea. J. Ethnopharmacol., 2007, 110(2), 323-333.
[http://dx.doi.org/10.1016/j.jep.2006.09.032] [PMID: 17084568]
[40]
Fernandes, E.S.; Passos, G.F.; Medeiros, R.; da Cunha, F.M.; Ferreira, J.; Campos, M.M.; Pianowski, L.F.; Calixto, J.B. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur. J. Pharmacol., 2007, 569(3), 228-236.
[http://dx.doi.org/10.1016/j.ejphar.2007.04.059] [PMID: 17559833]
[41]
El Jemli, M.; Kamal, R.; Marmouzi, I.; Doukkali, Z.; Bouidida, E.H.; Touati, D.; Nejjari, R.; El Guessabi, L.; Cherrah, Y.; Alaoui, K. Che-mical composition, acute toxicity, antioxidant and anti-inflammatory activities of Moroccan Tetraclinis articulata L. J. Tradit. Complement. Med., 2016, 7(3), 281-287.
[http://dx.doi.org/10.1016/j.jtcme.2016.06.006] [PMID: 28725621]
[42]
Park, Y.; Jung, S.M.; Yoo, S.A.; Kim, W.U.; Cho, C.S.; Park, B.J.; Woo, J.M.; Yoon, C.H. Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice. Int. Immunopharmacol., 2015, 29(2), 320-325.
[http://dx.doi.org/10.1016/j.intimp.2015.10.034] [PMID: 26590113]
[43]
Park, Y.; Yoo, S-A.; Kim, W-U.; Cho, C-S.; Woo, J-M.; Yoon, C-H. Anti-inflammatory effects of essential oils extracted from Cha-maecyparis obtusa on murine models of inflammation and RAW 264.7 cells. Mol. Med. Rep., 2016, 13(4), 3335-3341.
[http://dx.doi.org/10.3892/mmr.2016.4905] [PMID: 26936418]
[44]
Ramos, J.M.O.; Santos, C.A.; Santana, D.G.; Santos, D.A.; Alves, P.B.; Thomazzi, S.M. Chemical constituents and potential anti-inflammatory activity of the essential oil from the leaves of Croton argyrophyllus. Rev. Bras. Farmacogn., 2013, 23(4), 644-650.
[http://dx.doi.org/10.1590/S0102-695X2013005000045]
[45]
Martins, A.O.B.P.B.; Rodrigues, L.B.; Cesário, F.R.A.S.; de Oliveira, M.R.C.; Tintino, C.D.M.; Castro, F.F.E.; Alcântara, I.S.; Fernandes, M.N.M.; de Albuquerque, T.R.; da Silva, M.S.A.; de Sousa Araújo, A.A.; Júniur, L.J.Q.; da Costa, J.G.M.; de Menezes, I.R.A.; Wanderley, A.G. Anti-edematogenic and anti-inflammatory activity of the essential oil from Croton rhamnifolioides leaves and its major constituent 1,8-cineole (eucalyptol). Biomed. Pharmacother., 2017, 96, 384-395.
[http://dx.doi.org/10.1016/j.biopha.2017.10.005] [PMID: 29031196]
[46]
Veiga-Junior, V.F.; Pinto, A.C. The Copaifera L. genus. Quim. Nova, 2002, 25(2), 273-286.
[http://dx.doi.org/10.1590/S0100-40422002000200016]
[47]
Basile, A.C.; Sertié, J.A.A.; Freitas, P.C.D.; Zanini, A.C. Anti-inflammatory activity of oleoresin from Brazilian Copaifera. J. Ethnopharmacol., 1988, 22(1), 101-109.
[http://dx.doi.org/10.1016/0378-8741(88)90235-8] [PMID: 3352280]
[48]
Carvalho, J.C.T.; Cascon, V.; Possebon, L.S.; Morimoto, M.S.S.; Cardoso, L.G.V.; Kaplan, M.A.; Gilbert, B. Topical antiinflammatory and analgesic activities of Copaifera duckei dwyer. Phytother. Res., 2005, 19(11), 946-950.
[http://dx.doi.org/10.1002/ptr.1762] [PMID: 16317651]
[49]
Veiga, V.F., Junior; Zunino, L.; Patitucci, M.L.; Pinto, A.C.; Calixto, J.B. The inhibition of paw oedema formation caused by the oil of Copaifera multijuga Hayne and its fractions. J. Pharm. Pharmacol., 2006, 58(10), 1405-1410.
[http://dx.doi.org/10.1111/j.2042-7158.2006.tb01659.x] [PMID: 17034665]
[50]
Gomes, N. M.; de Rezende, C.M.; Fontes, S.P.; Matheus, M.E.; Pinto, Ada.C.; Fernandes, P.D. Characterization of the antinociceptive and anti-inflammatory activities of fractions obtained from Copaifera multijuga Hayne. J. Ethnopharmacol., 2010, 128(1), 177-183.
[http://dx.doi.org/10.1016/j.jep.2010.01.005] [PMID: 20064592]
[51]
Kobayashi, C.; Fontanive, T.O.; Enzweiler, B.G.; de Bona, L.R.; Massoni, T.; Apel, M.A.; Henriques, A.T.; Richter, M.F.; Ardenghi, P.; Suyenaga, E.S. Pharmacological evaluation of Copaifera multijuga oil in rats. Pharm. Biol., 2011, 49(3), 306-313.
[http://dx.doi.org/10.3109/13880209.2010.515595] [PMID: 21323483]
[52]
Veiga, V.F., Junior; Rosas, E.C.; Carvalho, M.V.; Henriques, M.G.M.O.; Pinto, A.C. Chemical composition and anti-inflammatory activity of copaiba oils from Copaifera cearensis Huber ex Ducke, Copaifera reticulata Ducke and Copaifera multijuga Hayne-A comparative study. J. Ethnopharmacol., 2007, 112(2), 248-254.
[http://dx.doi.org/10.1016/j.jep.2007.03.005] [PMID: 17446019]
[53]
Veiga, V.F., Jr; Zunino, L.; Calixto, J.B.; Patitucci, M.L.; Pinto, A.C. Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil. Phytother. Res., 2001, 15(6), 476-480.
[http://dx.doi.org/10.1002/ptr.976] [PMID: 11536374]
[54]
Dias, D.O.; Colombo, M.; Kelmann, R.G.; Kaiser, S.; Lucca, L.G.; Teixeira, H.F.; Limberger, R.P.; Veiga, V.F.; Koester, L.S. Optimization of copaiba oil-based nanoemulsions obtained by different preparation methods. Ind. Crops Prod., 2014, 59, 154-162.
[http://dx.doi.org/10.1016/j.indcrop.2014.05.007]
[55]
Lucca, L.G.; de Matos, S.P.; Borille, B.T. de O Dias, D.; Teixeira, H.F.; Veiga, V.F., Jr; Limberger, R.P.; Koester, L.S. Determination of -caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method. J. Pharm. Biomed. Anal., 2015, 104, 144-148.
[http://dx.doi.org/10.1016/j.jpba.2014.11.013] [PMID: 25499655]
[56]
Lucca, L.G.; De Matos, S.P.; De Mattos, C.B.; Teixeira, H.F.; Limberger, R.P.; Veiga, V.F.; De Araújo, B.V.; Koester, L.S. Nanoemulsifica-tion potentiates in vivo antiedematogenic effect of copaiba oil. J. Biomed. Nanotechnol., 2017, 13(5), 583-590.
[http://dx.doi.org/10.1166/jbn.2017.2366]
[57]
Lucca, L.G.; de Matos, S.P.; Kreutz, T.; Teixeira, H.F.; Veiga, V.F., Jr; de Araújo, B.V.; Limberger, R.P.; Koester, L.S. Anti-inflammatory effect from a hydrogel containing nanoemulsified copaiba oil (Copaifera multijuga Hayne). AAPS PharmSciTech, 2018, 19(2), 522-530.
[http://dx.doi.org/10.1208/s12249-017-0862-6] [PMID: 28828597]
[58]
Arrigoni-Blank, M.F.; Antoniolli, A.R.; Caetano, L.C.; Campos, D.A.; Blank, A.F.; Alves, P.B. Antinociceptive activity of the volatile oils of Hyptis pectinata L. Poit. (Lamiaceae) genotypes. Phytomedicine, 2008, 15(5), 334-339.
[http://dx.doi.org/10.1016/j.phymed.2007.09.009] [PMID: 17950588]
[59]
Nascimento, P.F.C.; Alviano, W.S.; Nascimento, A.L.C.; Santos, P.O.; Arrigoni-Blank, M.F.; de Jesus, R.A.; Azevedo, V.G.; Alviano, D.S.; Bolognese, A.M.; Trindade, R.C. Hyptis pectinata essential oil: Chemical composition and anti-Streptococcus mutans activity. Oral Dis., 2008, 14(6), 485-489.
[http://dx.doi.org/10.1111/j.1601-0825.2007.01405.x] [PMID: 18826378]
[60]
Raymundo, L.J.R.P.; Guilhon, C.C.; Alviano, D.S.; Matheus, M.E.; Antoniolli, A.R.; Cavalcanti, S.C.H.; Alves, P.B.; Alviano, C.S.; Fer-nandes, P.D. Characterisation of the anti-inflammatory and antinociceptive activities of the Hyptis pectinata (L.) Poit essential oil. J. Ethnopharmacol., 2011, 134(3), 725-732.
[http://dx.doi.org/10.1016/j.jep.2011.01.027] [PMID: 21277967]
[61]
Hajhashemi, V.; Ghannadi, A.; Sharif, B. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J. Ethnopharmacol., 2003, 89(1), 67-71.
[http://dx.doi.org/10.1016/S0378-8741(03)00234-4] [PMID: 14522434]
[62]
Silva, G.L.; Luft, C.; Lunardelli, A.; Amaral, R.H.; Melo, D.A.D.S.; Donadio, M.V.F.; Nunes, F.B.; de Azambuja, M.S.; Santana, J.C.; Mo-raes, C.M.B.; Mello, R.O.; Cassel, E.; Pereira, M.A.; de Oliveira, J.R. Antioxidant, analgesic and anti-inflammatory effects of lavender es-sential oil. An. Acad. Bras. Cienc., 2015, 87(2)(Suppl.), 1397-1408.
[http://dx.doi.org/10.1590/0001-3765201520150056] [PMID: 26247152]
[63]
Ricci, E.L.; Toyama, D.O.; Lago, J.H.G.; Romoff, P.; Kirsten, T.B.; Reis-silva, T.M.; Bernardi, M.M. Anti-nociceptive and anti-inflammatory actions of Nepeta cataria L. Var. Citriodora (Becker) balb. Essential oil in mice. J. Helth Sci. Inst., 2010, 28(3), 289-294.
[64]
Ali, T.; Javan, M.; Sonboli, A.; Semnanian, S. Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats. Daru, 2012, 20(1), 48.
[http://dx.doi.org/10.1186/2008-2231-20-48] [PMID: 23351375]
[65]
Rodrigues, L.B.; Martins, A.O.B.P.B.; Ribeiro-Filho, J.; Cesrio, F.R.A.S.; Castro, E. F.F.; de Albuquerque, T.R.; Fernandes, M.N.M.; da Silva, B.A.F.; Quintans Júnior, L.J.; Araújo, A.A.S.; Menezes, P.D.P.; Nunes, P.S.; Matos, I.G.; Coutinho, H.D.M.; Goncalves Wanderley, A.; de Menezes, I.R.A. Anti-inflammatory activity of the essential oil obtained from Ocimum basilicum complexed with β-cyclodextrin (β-CD) in mice. Food Chem. Toxicol., 2017, 109(Pt 2), 836-846.
[http://dx.doi.org/10.1016/j.fct.2017.02.027] [PMID: 28235614]
[66]
Rodrigues, L.B.; Oliveira Brito Pereira Bezerra Martins, A.; Cesário, F.R.A.S.; Ferreira, E. Castro, F.; de Albuquerque, T.R.; Martins Fer-nandes, M.N.; Fernandes da Silva, B.A.; Quintans Júnior, L.J.; da Costa, J.G.M.; Melo Coutinho, H.D.; Barbosa, R.; Alencar de Menezes, I.R. Anti-inflammatory and antiedematogenic activity of the Ocimum basilicum essential oil and its main compound estragole: In vivo mouse models. Chem. Biol. Interact., 2016, 257, 14-25.
[http://dx.doi.org/10.1016/j.cbi.2016.07.026] [PMID: 27474066]
[67]
Silva-Filho, S.E.; Wiirzler, L.A.M.; Cavalcante, H.A.O.; Uchida, N.S.; de Souza Silva-Comar, F.M.; Cardia, G.F.E.; da Silva, E.L.; Aguiar, R.P.; Bersani-Amado, C.A.; Cuman, R.K.N. Effect of patchouli (Pogostemon cablin) essential oil on in vitro and in vivo leukocytes beha-vior in acute inflammatory response. Biomed. Pharmacother., 2016, 84, 1697-1704.
[http://dx.doi.org/10.1016/j.biopha.2016.10.084] [PMID: 27847207]
[68]
Takaki, I.; Bersani-Amado, L.E.; Vendruscolo, A.; Sartoretto, S.M.; Diniz, S.P.; Bersani-Amado, C.A.; Cuman, R.K.N. Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models. J. Med. Food, 2008, 11(4), 741-746.
[http://dx.doi.org/10.1089/jmf.2007.0524] [PMID: 19053868]
[69]
Barreto, R.S.S.; Quintans, J.S.S.; Amarante, R.K.L.; Nascimento, T.S.; Amarante, R.S.; Barreto, A.S.; Pereira, E.W.M.; Duarte, M.C.; Cou-tinho, H.D.M.; Menezes, I.R.A.; Zengin, G.; Aktumsek, A.; Quintans-Júnior, L.J. Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main com-pound, in mice. J. Ethnopharmacol., 2016, 191, 9-18.
[http://dx.doi.org/10.1016/j.jep.2016.06.022] [PMID: 27292196]
[70]
Sun, L.; Zong, S.B.; Li, J.C.; Lv, Y.Z.; Liu, L.N.; Wang, Z.Z.; Zhou, J.; Cao, L.; Kou, J.P.; Xiao, W. The essential oil from the twigs of Cinnamomum cassia Presl alleviates pain and inflammation in mice. J. Ethnopharmacol., 2016, 194(August), 904-912.
[http://dx.doi.org/10.1016/j.jep.2016.10.064] [PMID: 27780753]
[71]
Shin, W-Y.; Shim, D-W.; Kim, M-K.; Sun, X.; Koppula, S.; Yu, S.H.; Kim, H-B.; Kim, T-J.; Kang, T-B.; Lee, K-H. Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic responses via attenuation of inflammasome activation in experimental models. J. Ethnopharmacol., 2017, 205, 173-177.
[http://dx.doi.org/10.1016/j.jep.2017.03.043] [PMID: 28347828]
[72]
Lin, C.T.; Chen, C.J.; Lin, T.Y.; Tung, J.C.; Wang, S.Y. Anti-inflammation activity of fruit essential oil from Cinnamomum insularimonta-num Hayata. Bioresour. Technol., 2008, 99(18), 8783-8787.
[http://dx.doi.org/10.1016/j.biortech.2008.04.041] [PMID: 18513962]
[73]
Chao, L.K.; Hua, K.F.; Hsu, H.Y.; Cheng, S.S.; Lin, I.F.; Chen, C.J.; Chen, S.T.; Chang, S.T. Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling. Food Chem. Toxicol., 2008, 46(1), 220-231.
[http://dx.doi.org/10.1016/j.fct.2007.07.016] [PMID: 17868967]
[74]
Ballabeni, V.; Tognolini, M.; Giorgio, C.; Bertoni, S.; Bruni, R.; Barocelli, E. Ocotea quixos Lam. essential oil: In vitro and in vivo investi-gation on its anti-inflammatory properties. Fitoterapia, 2010, 81(4), 289-295.
[http://dx.doi.org/10.1016/j.fitote.2009.10.002] [PMID: 19825398]
[75]
Silva, J.; Abebe, W.; Sousa, S.M.; Duarte, V.G.; Machado, M.I.L.; Matos, F.J.A. Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. J. Ethnopharmacol., 2003, 89(2-3), 277-283.
[http://dx.doi.org/10.1016/j.jep.2003.09.007] [PMID: 14611892]
[76]
Lima, D.K.S.; Ballico, L.J.; Rocha Lapa, F.; Gonçalves, H.P.; de Souza, L.M.; Iacomini, M.; Werner, M.F.; Baggio, C.H.; Pereira, I.T.; da Silva, L.M.; Facundo, V.A.; Santos, A.R. Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essen-tial oil from Piper aleyreanum C.DC in rodents. J. Ethnopharmacol., 2012, 142(1), 274-282.
[http://dx.doi.org/10.1016/j.jep.2012.05.016] [PMID: 22588049]
[77]
Pinheiro, B.G.; Silva, A.S.B.; Souza, G.E.P.; Figueiredo, J.G.; Cunha, F.Q.; Lahlou, S.; da Silva, J.K.R.; Maia, J.G.S.; Sousa, P.J.C. Chemi-cal composition, antinociceptive and anti-inflammatory effects in rodents of the essential oil of Peperomia serpens (Sw.) Loud. J. Ethnopharmacol., 2011, 138(2), 479-486.
[http://dx.doi.org/10.1016/j.jep.2011.09.037] [PMID: 21971207]
[78]
Hoff Brait, D.R.; Mattos Vaz, M.S.; da Silva Arrigo, J.; Borges de Carvalho, L.N.; Souza de Araújo, F.H.; Vani, J.M.; da Silva Mota, J.; Cardoso, C.A.L.; Oliveira, R.J.; Negrão, F.J.; Kassuya, C.A.; Arena, A.C. Toxicological analysis and anti-inflammatory effects of essential oil from Piper vicosanum leaves. Regul. Toxicol. Pharmacol., 2015, 73(3), 699-705.
[http://dx.doi.org/10.1016/j.yrtph.2015.10.028] [PMID: 26545326]
[79]
Branquinho, L.S.; Santos, J.A.; Cardoso, C.A.L.; Mota, J.D.S.; Junior, U.L.; Kassuya, C.A.L.; Arena, A.C. Anti-inflammatory and toxico-logical evaluation of essential oil from Piper glabratum leaves. J. Ethnopharmacol., 2017, 198(198), 372-378.
[http://dx.doi.org/10.1016/j.jep.2017.01.008] [PMID: 28109914]
[80]
Akhila, A. Essential Oil-Bearing Grasses: The Gebus Cymbopogon; CRC Press, 2010.
[81]
Boukhatem, M.N.; Ferhat, M.A.; Kameli, A.; Saidi, F.; Kebir, H.T. Lemon grass (Cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan J. Med., 2014, 9(1), 25431.
[http://dx.doi.org/10.3402/ljm.v9.25431] [PMID: 28156278]
[82]
Chandrashekar, K.S.; Prasanna, K.S. Analgesic and anti-inflammatory activities of the essential oil from Cymbopogon flexuosus. Pharmacogn. J., 2010, 2(14), 23-25.
[http://dx.doi.org/10.1016/S0975-3575(10)80067-7]
[83]
Rungqu, P.; Oyedeji, O.; Nkeh-Chungag, B.; Songca, S.; Oluwafemi, O.; Oyedeji, A. Anti-inflammatory activity of the essential oils of Cymbopogon validus (Stapf) Stapf ex Burtt Davy from Eastern Cape, South Africa. Asian Pac. J. Trop. Med., 2016, 9(5), 426-431.
[http://dx.doi.org/10.1016/j.apjtm.2016.03.031] [PMID: 27261849]
[84]
Kummer, R.; Fachini-queiroz, F.C.; Estevão-silva, C.F.; Grespan, R.; Silva, E.L.; Bersani-amado, C.A.; Kenji, R.; Cuman, N. Evaluation of anti-inflammatory activity of citrus latifolia tanaka essential oil and limonene in experimental mouse models. Evidence-Based Comple-ment. Altern. Med., 2013, 2013, 859083.
[http://dx.doi.org/10.1155/2013/859083]
[85]
Amorim, J.L.; Simas, D.L.R.; Pinheiro, M.M.G.; Moreno, D.S.A.; Alviano, C.S.; da Silva, A.J.R.; Fernandes, P.D. Anti-inflammatory pro-perties and chemical characterization of the essential oils of four citrus species. PLoS One, 2016, 11(4), e0153643.
[http://dx.doi.org/10.1371/journal.pone.0153643] [PMID: 27088973]
[86]
Aguiar, J.S.; Costa, M.C.C. Lippia Alba (Mill.) N.E. Brown (Verbenaceae): Levantamento de Publicacões Nas Áreas Química, Agronômica e Farmacológica, No Período de 1979 a 2004. Rev. Bras. Plantas Med., 2005, 8, 79-84.
[http://dx.doi.org/10.1590/1981-5271v29.2-012]
[87]
Mendes, S.S.; Bomfim, R.R.; Jesus, H.C.R.; Alves, P.B.; Blank, A.F.; Estevam, C.S.; Antoniolli, A.R.; Thomazzi, S.M. Evaluation of the analgesic and anti-inflammatory effects of the essential oil of Lippia gracilis leaves. J. Ethnopharmacol., 2010, 129(3), 391-397.
[http://dx.doi.org/10.1016/j.jep.2010.04.005] [PMID: 20420889]
[88]
Guilhon, C.C.; Raymundo, L.J.R.P.; Alviano, D.S.; Blank, A.F.; Arrigoni-Blank, M.F.; Matheus, M.E.; Cavalcanti, S.C.H.; Alviano, C.S.; Fernandes, P.D. Characterisation of the anti-inflammatory and antinociceptive activities and the mechanism of the action of Lippia gracilis essential oil. J. Ethnopharmacol., 2011, 135(2), 406-413.
[http://dx.doi.org/10.1016/j.jep.2011.03.032] [PMID: 21420477]
[89]
Monteiro, M.V.B.; de Melo Leite, A.K.; Bertini, L.M.; de Morais, S.M.; Nunes-Pinheiro, D.C.S. Topical anti-inflammatory, gastroprotecti-ve and antioxidant effects of the essential oil of Lippia sidoides Cham. leaves. J. Ethnopharmacol., 2007, 111(2), 378-382.
[http://dx.doi.org/10.1016/j.jep.2006.11.036] [PMID: 17254726]
[90]
Veras, H.N.H.; Araruna, M.K.A.; Costa, J.G.M.; Coutinho, H.D.M.; Kerntopf, M.R.; Botelho, M.A.; Menezes, I.R. Topical antiinflamma-tory activity of essential oil of Lippia sidoides cham: Possible mechanism of action. Phytother. Res., 2013, 27(2), 179-185.
[http://dx.doi.org/10.1002/ptr.4695] [PMID: 22511564]
[91]
Pongprayoon, U.; Soontornsaratune, P.; Jarikasem, S.; Sematong, T.; Wasuwat, S.; Claeson, P. Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part I: The essential oil. Phytomedicine, 1997, 3(4), 319-322.
[http://dx.doi.org/10.1016/S0944-7113(97)80003-7] [PMID: 23195188]
[92]
Baser, K.H.C.; Buchbauer, G., Eds.; Handbook of Essential Oils: Science, Technology and Applications, 2nd ed; CRC Press: New York, 2010.
[93]
Brito, A.R.; Brito, A.A. Forty years of Brazilian medicinal plant research. J. Ethnopharmacol., 1993, 39(1), 53-67.
[http://dx.doi.org/10.1016/0378-8741(93)90050-F] [PMID: 8331962]

Rights & Permissions Print Cite
Article Metrics
59
1
World Chagas Disease
© 2024 Bentham Science Publishers | Privacy Policy