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Current Traditional Medicine


ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Systematic Review Article

Effects and Mechanisms of Medicinal Plants on Healing Scars: A Systematic Review

Author(s): Catherine MT Sherwin and Saeid Heidari-Soureshjani*

Volume 8, Issue 1, 2022

Published on: 12 January, 2022

Article ID: e221121198156 Pages: 12

DOI: 10.2174/2215083807666211122102406

Price: $65


Background: Scars can be a cosmetic disfigurement and can tremendously impact psychological, emotional, and social well-being. Some medicinal plants exert anti-scar properties via various mechanisms of action, many of which have not been clearly defined.

Objective: This study will evaluate the effects of these medicinal plants with anti-scar properties and review the known underlying mechanisms related to the treatment and prevention of hypertrophic scars.

Methods: The keywords used in the literature search included (Wound healing OR Re-epithelialization OR Regeneration) and (Medicinal plants OR Phyto* OR herb) and (Cytokines OR Collagen OR Fibroblasts). Publications indexed in the Institute for Scientific Information (ISI) and PubMed databases were included in the review. Articles with no accessible full texts, non-English language articles, review articles, studies with non-positive effects, and studies that were not related to the study’s aim were excluded from the study. The agreement for exclusion required all authors to concur. Finally, after reviewing all available literature, 61 articles were included in this systematic review.

Results: Currently available evidence shows that medicinal plants and their derivatives seem to have properties that can prevent hypertrophic scars. This is achieved by accelerating the scar healing process, reducing inflammatory cytokines, suppressing proliferation, and inducing apoptosis in scar fibroblasts by regulating several signaling pathways. Additionally, they can reduce collagen deposition and have antimicrobial effects at the wound site.

Conclusion: Topical use of medicinal plants as complementary medicine with varying mechanisms of action can reduce scar formation. They exert these properties mainly due to their anti-inflammatory, antioxidant, and antimicrobial properties. Therefore, these mechanisms reduce the healing time of the wound and thus prevent the formation of hypertrophic scars. Medicinal plants can be used safely and efficiently when applied topically to improve or prevent hypertrophic scars.

Keywords: Scar, wound healing, medicinal plants, herbal medicine, re-epithelialization, regeneration.

Graphical Abstract
McFadden KL, Stock GN, Gowen CR III. Leadership, safety climate, and continuous quality improvement: impact on process quality and patient safety. Health Care Manage Rev 2015; 40(1): 24-34.
[] [PMID: 24566246]
Zhu Z, Ding J, Tredget EE. The molecular basis of hypertrophic scars. Burns Trauma 2016; 4: 2.
[] [PMID: 27574672]
Edwards MT. An organizational learning framework for patient safety. Am J Med Qual 2017; 32(2): 148-55.
[] [PMID: 26917805]
Ziolkowski N, Kitto SC, Jeong D, et al. Psychosocial and quality of life impact of scars in the surgical, traumatic and burn populations: a scoping review protocol. BMJ Open 2019; 9(6): e021289.
[] [PMID: 31164358]
Borthwick LA, Wynn TA, Fisher AJ. Cytokine mediated tissue fibrosis. Biochim Biophys Acta 2013; 1832(7): 1049-60.
[] [PMID: 23046809]
Imran M, Sharma JN, Kamal M, Asif M. Standardization and wound-healing activity of petroleum, ethanolic and aqueous extracts of ficus benghalensis leaves. J Pharm Chem 2021; 54: 1057-62.
Thakur R, Jain N, Pathak R, Sandhu SS. Practices in wound healing studies of plants. Evid Based Complement Alternat Med 2011; 2011: 438056.
[] [PMID: 21716711]
Amini-Nik S, Yousuf Y, Jeschke MG. Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions. Adv Drug Deliv Rev 2018; 123: 135-54.
[] [PMID: 28757325]
Mokos ZB, Jović A, Grgurević L, et al. Current therapeutic approach to hypertrophic scars. Front Med (Lausanne) 2017; 4: 83.
[] [PMID: 28676850]
Al-Bayaty FH, Abdulla MA, Abu Hassan MI, Ali HM. Effect of Andrographis paniculata leaf extract on wound healing in rats. Nat Prod Res 2012; 26(5): 423-9.
[] [PMID: 21660840]
Wu J-G, Wei Y-J, Ran X, Zhang H, Nian H, Qin LP. Inhibitory effects of essential oil from rhizomes of Ligusticum chuanxiong on hypertrophic scarring in the rabbit ear model. Pharm Biol 2011; 49(7): 764-9.
[] [PMID: 21639690]
Samadi S, Khadivzadeh T, Emami A, Moosavi NS, Tafaghodi M, Behnam HR. The effect of Hypericum perforatum on the wound healing and scar of cesarean. J Altern Complement Med 2010; 16(1): 113-7.
[] [PMID: 20064022]
Ragi J, Pappert A, Rao B, Havkin-Frenkel D, Milgraum S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J Drugs Dermatol 2011; 10(10): 1168-72.
[PMID: 21968667]
West DP, Zhu YF. Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. Am J Infect Control 2003; 31(1): 40-2.
[] [PMID: 12548256]
Singh S, Gupta A, Gupta B. Scar free healing mediated by the release of aloe vera and manuka honey from dextran bionanocomposite wound dressings. Int J Biol Macromol 2018; 120(Pt B): 1581-90.
[] [PMID: 30248422]
Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling: An Experimental Study. Ann Plast Surg 2016; 77(1): 37-46.
[] [PMID: 25003428]
Akhoondinasab MR, Akhoondinasab M, Saberi M. Comparison of healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. World J Plast Surg 2014; 3(1): 29-34.
[PMID: 25489521]
Brandão ML, Reis PR, Araújo LA, Araújo AC, Santos MH, Miguel MP. Evaluation of wound healing treated with latex derived from rubber trees and Aloe Vera extract in rats. Acta Cir Bras 2016; 31(9): 570-7.
[] [PMID: 27737341]
Chanprapaph K, Tanrattanakorn S, Wattanakrai P, Wongkitisophon P, Vachiramon V. Effectiveness of onion extract gel on surgical scars in asians. Dermatol Res Pract 2012; 2012: 212945.
[] [PMID: 22924037]
Hosnuter M, Payasli C, Isikdemir A, Tekerekoglu B. The effects of onion extract on hypertrophic and keloid scars. J Wound Care 2007; 16(6): 251-4.
[] [PMID: 17722521]
Campanati A, Ceccarelli G, Brisigotti V, et al. Effects of in vivo application of an overnight patch containing Allium cepa, allantoin, and pentaglycan on hypertrophic scars and keloids: Clinical, videocapillaroscopic, and ultrasonographic study. Dermatol Ther 2021; 34(1): e14665.
[] [PMID: 33314582]
Güngör ES, Güzel D, Zebitay AG, İlhan G, Verit FF. The efficacy of onion extract in the management of subsequent abdominal hypertrophic scar formation. J Wound Care 2020; 29(10): 612-6.
[] [PMID: 33052789]
Pikuła M, Żebrowska ME, Pobłocka-Olech L, Krauze-Baranowska M, Sznitowska M, Trzonkowski P. Effect of enoxaparin and onion extract on human skin fibroblast cell line - therapeutic implications for the treatment of keloids. Pharm Biol 2014; 52(2): 262-7.
[] [PMID: 24074438]
Koc E, Arca E, Surucu B, Kurumlu Z. An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Surg 2008; 34(11): 1507-14.
[PMID: 18798752]
Conti V, Corbi G, Iannaccone T, et al. Effectiveness and tolerability of a patch containing onion extract and allantoin for cesarean section scars. Front Pharmacol 2020; 11: 569514.
[] [PMID: 33101027]
Prager W, Gauglitz GG. Effectiveness and safety of an overnight patch containing allium cepa extract and allantoin for post-dermatologic surgery scars. Aesthetic Plast Surg 2018; 42(4): 1144-50.
[] [PMID: 29948103]
Campanati A, Savelli A, Sandroni L, et al. Effect of allium cepa-allantoin-pentaglycan gel on skin hypertrophic scars: clinical and video-capillaroscopic results of an open-label, controlled, nonrandomized clinical trial. Dermatol Surg 2010; 36(9): 1439-44.
[] [PMID: 20626444]
Ocampo-Candiani J, Vázquez-Martínez OT, Iglesias Benavides JL, Buske K, Lehn A, Acker C. The prophylactic use of a topical scar gel containing extract of Allium cepae, allantoin, and heparin improves symptoms and appearance of cesarean-section scars compared with untreated scars. J Drugs Dermatol 2014; 13(2): 176-82.
[PMID: 24509969]
Draelos ZD, Baumann L, Fleischer AB Jr, Plaum S, Avakian EV, Hardas B. A new proprietary onion extract gel improves the appearance of new scars: a randomized, controlled, blinded-investigator study. J Clin Aesthet Dermatol 2012; 5(6): 18-24.
[PMID: 22768353]
Li Y, Sun Y, Ma H, Chen X, Liu J. Rheum rhabarbarum extract promotes healing of the incision through relieving inflammation and stimulating angiogenesis. Pak J Pharm Sci 2016; 29(4)(Suppl.): 1437-41.
[PMID: 27592494]
Patil MVK, Kandhare AD, Bhise SD. Pharmacological evaluation of ethanolic extract of Daucus carota Linn root formulated cream on wound healing using excision and incision wound model. Asian Pac J Trop Biomed 2012; 2: S646-55.
Maharani SC, Julianto I, Widhiati S. The role of beluntas (pluchea indica less.) leaf extract in preventing the occurrence of Ainn vitropreliminary study fibroblasts hyperproliferation: An in vitro preliminary study. Dermatol Rep 2019; 11(S1)
Paocharoen V. The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients. J Med Assoc Thai 2010; 93(Suppl. 7): S166-70.
[PMID: 21298840]
Kim WS, Lee JS, Bae GY, et al. Extract of Aneilema keisak inhibits transforming growth factor-β-dependent signalling by inducing Smad2 downregulation in keloid fibroblasts. Exp Dermatol 2013; 22(1): 69-71.
[] [PMID: 23278899]
Jaszewska E, Soin M, Filipek A, Naruszewicz M. UVA-induced ROS generation inhibition by Oenothera paradoxa defatted seeds extract and subsequent cell death in human dermal fibroblasts. J Photochem Photobiol B 2013; 126: 42-6.
[] [PMID: 23892189]
Baek YS, Ryu YB, Curtis-Long MJ, et al. Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg Med Chem 2009; 17(1): 35-41.
[] [PMID: 19046886]
Park G, Yoon BS, Moon J-H, et al. Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway. J Invest Dermatol 2008; 128(10): 2429-41.
[] [PMID: 18463684]
Vinaik R, Barayan D, Auger C, Abdullahi A, Jeschke MG. Regulation of glycolysis and the Warburg effect in wound healing. JCI Insight 2020; 5(17): e138949.
[] [PMID: 32750036]
Shedoeva A, Leavesley D, Upton Z, Fan C. Wound healing and the use of medicinal plants. Evid Based Complement Alternat Med 2019; 2019: 2684108.
[] [PMID: 31662773]
Jia S, Xie P, Hong SJ, et al. Intravenous curcumin efficacy on healing and scar formation in rabbit ear wounds under nonischemic, ischemic, and ischemia-reperfusion conditions. Wound Repair Regen 2014; 22(6): 730-9.
[] [PMID: 25230783]
Demirel C, Turkoz D, Yazicioglu IM, Cokluk C. The Preventive Effect of Curcumin on the Experimental Rat Epidural Fibrosis Model. World Neurosurg 2021; 145: e141-8.
[] [PMID: 33010510]
Pandey VK, Ajmal G, Upadhyay SN, Mishra PK. Nano-fibrous scaffold with curcumin for anti-scar wound healing. Int J Pharm 2020; 589: 119858.
[] [PMID: 32911047]
Zhang J, Song M, Li W, Zhao F, Li Y. Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and β-catenin pathways. Mol Immunol 2019; 116: 191-8.
[] [PMID: 31710976]
Bhattacharya D, Tiwari R, Bhatia T, et al. Accelerated and scarless wound repair by a multicomponent hydrogel through simultaneous activation of multiple pathways. Drug Deliv Transl Res 2019; 9(6): 1143-58.
[] [PMID: 31317345]
Nguyen MH, Vu NB, Nguyen TH, et al. In vivo comparison of wound healing and scar treatment effect between curcumin-oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome. J Microencapsul 2019; 36(2): 156-68.
[] [PMID: 31030591]
Liu XJ, Xu MJ, Fan ST, et al. Xiamenmycin attenuates hypertrophic scars by suppressing local inflammation and the effects of mechanical stress. J Invest Dermatol 2013; 133(5): 1351-60.
[] [PMID: 23303451]
Ma J, Ji C, Xiao D, Fan Q. Quercetin-loaded solid lipid nanoparticles-enriched hydrogel prevents the formation of skin scars by inhibiting TGF-β/Smad signaling pathway. Biomed Res (Aligarh) 2018; 29: 1321-6.
Doersch KM, Newell-Rogers MK. The impact of quercetin on wound healing relates to changes in αV and β1 integrin expression. Exp Biol Med (Maywood) 2017; 242(14): 1424-31.
[] [PMID: 28549404]
Al-Madhagy SA, Mostafa NM, Youssef FS, Awad GEA, Eldahshan OA, Singab ANB. Metabolic profiling of a polyphenolic-rich fraction of Coccinia grandis leaves using LC-ESI-MS/MS and in vivo validation of its antimicrobial and wound healing activities. Food Funct 2019; 10(10): 6267-75.
[] [PMID: 31584060]
Dai J, Sun Y, Yan L, Wang J, Li X, He J. Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing epidural fibrosis. PeerJ 2017; 5: e2858-58.
[] [PMID: 28097065]
Sun Y, Wang L, Sun S, Liu B, Wu N, Cao X. The effect of 10-hydroxycamptothecine in preventing fibroblast proliferation and epidural scar adhesion after laminectomy in rats. Eur J Pharmacol 2008; 593(1-3): 44-8.
[] [PMID: 18680742]
Zeng G, Zhong F, Li J, Luo S, Zhang P. Resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. Biosci Biotechnol Biochem 2013; 77(12): 2389-96.
[] [PMID: 24317052]
Pang K, Li B, Tang Z, et al. Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis. Mol Med Rep 2020; 22(4): 3440-52.
[] [PMID: 32945452]
Zhao CC, Zhu L, Wu Z, Yang R, Xu N, Liang L. Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation. Regen Biomater 2020; 7(1): 99-107.
[PMID: 32440361]
Zhang H, Zhang Y, Jiang YP, et al. Curative effects of oleanolic Acid on formed hypertrophic scars in the rabbit ear model. Evid Based Complement Alternat Med 2012; 2012: 837581.
[] [PMID: 23326292]
Wei YJ, Yan XQ, Ma L, Wu JG, Zhang H, Qin LP. Oleanolic acid inhibits hypertrophic scarring in the rabbit ear model. Clin Exp Dermatol 2011; 36(5): 528-33.
[] [PMID: 21392079]
Nong X, Rajbanshi G, Chen L, et al. Effect of artesunate and relation with TGF-β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear. Arch Dermatol Res 2019; 311(10): 761-72.
[] [PMID: 31396694]
Cui W, Cheng L, Hu C, Li H, Zhang Y, Chang J. Electrospun poly(L-lactide) fiber with ginsenoside rg3 for inhibiting scar hyperplasia of skin. PLoS One 2013; 8(7): e68771.
[] [PMID: 23874757]
Tang M, Wang W, Cheng L, et al. The inhibitory effects of 20(R)- ginsenoside Rg3 on the proliferation, angiogenesis, and collagen synthesis of hypertrophic scar derived fibroblasts in vitro. Iran J Basic Med Sci 2018; 21(3): 309-17.
[PMID: 29511498]
Song J, Xu H, Lu Q, et al. Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways. Burns 2012; 38(5): 677-84.
[] [PMID: 22360962]
Cao C, Li S, Dai X, et al. Genistein inhibits proliferation and functions of hypertrophic scar fibroblasts. Burns 2009; 35(1): 89-97.
[] [PMID: 18976864]
Jurzak M, Adamczyk K. Influence of genistein on c-Jun, c-Fos and Fos-B of AP-1 subunits expression in skin keratinocytes, fibroblasts and keloid fibroblasts cultured in vitro. Acta Pol Pharm 2013; 70(2): 205-13.
[PMID: 23614275]
Chen X, Peng LH, Li N, et al. The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo. J Ethnopharmacol 2012; 139(3): 721-7.
[] [PMID: 22143155]
Lee JH, Kim HL, Lee MH, et al. Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model. Phytomedicine 2012; 19(13): 1223-7.
[] [PMID: 22939261]
Tang B, Zhu B, Liang Y, et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. Arch Dermatol Res 2011; 303(8): 563-72.
[] [PMID: 21240513]
Aras A, Bursal E, Alan Y, et al. Polyphenolic Content, Antioxidant Potential and Antimicrobial Activity of Satureja boissieri. Iran J Chem Chem Eng 2018; 37: 209-19.
Udegbunam SO, Udegbunam RI, Muogbo CC, Anyanwu MU, Nwaehujor CO. Wound healing and antibacterial properties of methanolic extract of Pupalia lappacea Juss in rats. BMC Complement Altern Med 2014; 14: 157-57.
[] [PMID: 24886368]
Deseo MA, Elkins A, Rochfort S, Kitchen B. Antioxidant activity and polyphenol composition of sugarcane molasses extract. Food Chem 2020; 314: 126180.
[] [PMID: 31954937]
Silinsin M, Bursal E. UHPLC-MS/MS phenolic profiling and in vitro antioxidant activities of Inula graveolens (L.) Desf. Nat Prod Res 2018; 32(12): 1467-71.
[] [PMID: 28697630]
Bursal E, Boğa R. Polyphenols analysed by UHPLC-ESI-MS/MS and antioxidant activities of molasses, acorn and leaves of oak (Quercus robur subsp. pedunculiflora). Prog Nutr 2018; 20: 165-75.
Bursal E, Aras A, Kılıç Ö. Evaluation of antioxidant capacity of endemic plant Marrubium astracanicum subsp. macrodon: Identification of its phenolic contents by using HPLC-MS/MS. Nat Prod Res 2019; 33(13): 1975-9.
[] [PMID: 29842794]
Tummalapalli M, Berthet M, Verrier B, Deopura BL, Alam MS, Gupta B. Composite wound dressings of pectin and gelatin with aloe vera and curcumin as bioactive agents. Int J Biol Macromol 2016; 82: 104-13.
[] [PMID: 26529192]
Chuangsuwanich A, Jongjamfa K. The efficacy of combined herbal extracts gel preparation in the prevention of postsurgical hypertrophic scar formation. Dermatol Ther (Heidelb) 2014; 4(2): 187-95.
[] [PMID: 24962057]
Cho JW, Cho SY, Lee SR, Lee KS. Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. Int J Mol Med 2010; 25(3): 347-52.
[PMID: 20127038]
Hou Q, He WJ, Hao HJ, et al. The four-herb Chinese medicine ANBP enhances wound healing and inhibits scar formation via bidirectional regulation of transformation growth factor pathway. PLoS One 2014; 9(12): e112274.
[] [PMID: 25489732]
Hou Q, He WJ, Chen L, et al. Effects of the four-herb compound ANBP on wound healing promotion in diabetic mice. Int J Low Extrem Wounds 2015; 14(4): 335-42.
[] [PMID: 25795279]
Cao FH, OuYang WQ, Wang YP, Yue PF, Li SP. A combination of a microemulsion and a phospholipid complex for topical delivery of oxymatrine. Arch Pharm Res 2011; 34(4): 551-62.
[] [PMID: 21544720]
Yahiaoui F, Zaouani M, Kardjadj M, et al. Antibacterial, antioxidant and wound healing activities of Marrubium vulgare and Cytisus triflorus extracts native to Algeria. Phytotherapie 2018; 16: S32-9.
Ye Q, Wang SJ, Chen JY, Rahman K, Xin HL, Zhang H. Medicinal plants for the treatment of hypertrophic scars. Evid Based Complement Alternat Med 2015; 2015: 101340.
[] [PMID: 25861351]
Derakhshanfar A, Moayedi J, Derakhshanfar G, Poostforoosh Fard A. The role of Iranian medicinal plants in experimental surgical skin wound healing: An integrative review. Iran J Basic Med Sci 2019; 22(6): 590-600.
[PMID: 31231485]
Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 2008; 453(7193): 314-21.
[] [PMID: 18480812]
Wilgus TA, Roy S, McDaniel JC. Neutrophils and wound repair: positive actions and negative reactions. Adv Wound Care (New Rochelle) 2013; 2(7): 379-88.
[] [PMID: 24527354]
Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83(3): 835-70.
[] [PMID: 12843410]
Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci 2017; 18(3): 18.
[] [PMID: 28287424]
Sharma RK, John JR. Role of stem cells in the management of chronic wounds. Indian J Plast Surg 2012; 45(2): 237-43.
[] [PMID: 23162222]
Rousselle P, Braye F, Dayan G. Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies. Adv Drug Deliv Rev 2019; 146: 344-65.
[] [PMID: 29981800]
Martínez-Romero D, Alburquerque N, Valverde J, et al. Postharvest sweet cherry quality and safety maintenance by Aloe vera treatment: a new edible coating. Postharvest Biol Technol 2006; 39: 93-100.
Hemmati AA, Houshmand G, Nemati M, et al. Wound healing effects of persian Oak (Quercus brantii) ointment in rats. Jundishapur J Nat Pharm Prod 2015; 10: e25508.
Georgescu M, Marinas O, Popa M, et al. Natural compounds for wound healing. Worldwide Wound Healing-Innovation in Natural and Conventional MethodsPortugal IntechOpen 2016; pp61-89.
Driskell RR, Lichtenberger BM, Hoste E, et al. Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature 2013; 504(7479): 277-81.
[] [PMID: 24336287]
Liu Y, Li Y, Li N, et al. TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21. Sci Rep 2016; 6: 32231.
[] [PMID: 27554193]
Tewtrakul S, Tungcharoen P, Sudsai T, Karalai C, Ponglimanont C, Yodsaoue O. Antiinflammatory and wound healing effects of caesalpinia sappan L. Phytother Res 2015; 29(6): 850-6.
[] [PMID: 25760294]
Phan TT, Lim IJ, Sun L, et al. Quercetin inhibits fibronectin production by keloid-derived fibroblasts. Implication for the treatment of excessive scars. J Dermatol Sci 2003; 33(3): 192-4.
[] [PMID: 14643528]
Slemp AE, Kirschner RE. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr 2006; 18(4): 396-402.
[] [PMID: 16914994]
Xue M, Jackson CJ. Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring. Adv Wound Care (New Rochelle) 2015; 4(3): 119-36.
[] [PMID: 25785236]
Hallock GG, Rice DC, Merkel JR, DiPaolo BR. Analysis of collagen content in the fetal wound. Ann Plast Surg 1988; 21(4): 310-5.
[] [PMID: 3232919]
Li J, Zhang YP, Kirsner RS. Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix. Microsc Res Tech 2003; 60(1): 107-14.
[] [PMID: 12500267]
Honnegowda TM, Kumar P, Udupa EGP, et al. Role of angiogenesis and angiogenic factors in acute and chronic wound healing. Plast Aesthet Res 2015; 2: 243-9.
Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 2011; 17(1-2): 113-25.
[] [PMID: 20927486]
Klass BR, Branford OA, Grobbelaar AO, Rolfe KJ. The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-beta1-stimulated wound contraction. Wound Repair Regen 2010; 18(1): 80-8.
[] [PMID: 20002896]
Cuttle L, Kempf M, Kravchuk O, et al. The efficacy of Aloe vera, tea tree oil and saliva as first aid treatment for partial thickness burn injuries. Burns 2008; 34(8): 1176-82.
[] [PMID: 18603378]
Song T, Kim KH, Lee KW. Randomised comparison of silicone gel and onion extract gel for post-surgical scars. J Obstet Gynaecol 2018; 38(5): 702-7.
[] [PMID: 29514524]
Owji N, Khademi B, Khalili MR. Effectiveness of topical onion extract gel in the cosmetic appearance of blepharoplasty scar. J Clin Aesthet Dermatol 2018; 11(10): 31-5.
[PMID: 30519377]
Jackson BA, Shelton AJ. Pilot study evaluating topical onion extract as treatment for postsurgical scars. Dermatol Surg 1999; 25(4): 267-9.
[] [PMID: 10417579]
Teshome K, Gebre-Mariam T, Asres K, Perry F, Engidawork E. Toxicity studies on dermal application of plant extract of Plumbago zeylanica used in Ethiopian traditional medicine. J Ethnopharmacol 2008; 117(2): 236-48.
[] [PMID: 18339496]
Mantle D, Gok MA, Lennard TW. Adverse and beneficial effects of plant extracts on skin and skin disorders. Adverse Drug React Toxicol Rev 2001; 20(2): 89-103.
[PMID: 11482001]

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