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Anti-Infective Agents

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ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

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Mini-Review Article

Natural Products for Targeting Acanthamoeba spp.

Author(s): Yassmin Isse Wehelie, Aishath Leesha Nasih, Ayaz Anwar*, Ruqaiyyah Siddiqui, Sutherland Maciver and Naveed Ahmed Khan*

Volume 20, Issue 3, 2022

Published on: 16 February, 2022

Article ID: e191121198116 Pages: 13

DOI: 10.2174/2211352519666211119091316

Price: $65

Abstract

Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.

Keywords: Natural products, parasite, granulomatous amoebic encephalitis, protozoa, keratitis, treatment.

Graphical Abstract

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