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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Copper Complexes as Antitumor Agents: In vitro and In vivo Evidence

Author(s): Lucia M. Balsa, Enrique J. Baran and Ignacio E. León *

Volume 30, Issue 5, 2023

Published on: 14 January, 2022

Page: [510 - 557] Pages: 48

DOI: 10.2174/0929867328666211117094550

Price: $65


Copper is an essential element for most aerobic organisms, with an important function as a structural and catalytic cofactor, and in consequence, it is implicated in several biological actions.

The relevant aspects of chemistry and biochemistry and the importance of copper compounds in medicine give us a comprehensive knowledge of the multifaceted applications of copper in physiology and physiopathology.

In this review, we present an outline of the chemistry, and the antitumor properties of copper complexes on breast, colon, and lung cancer cells focus on the role of copper in cancer, the relationship between structure-activity, molecular targets, and the study of the mechanism of action involved in its anticancer activity. This overview is expected to contribute to understanding the design, synthesis, and uses of copper complexes as antitumor agents in the most common cancers.

Keywords: Copper, cancer, mechanism of action, SAR, cisplatin, tumors.

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