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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Small Molecules as LIM Kinase Inhibitors

Author(s): Syed N.A. Bukhari*, Michael A. Tandiary, Mohammad M. Al-Sanea, Mohamed A. Abdelgawad, Chin F. Chee and Muhammad A. Hussain

Volume 29, Issue 17, 2022

Published on: 18 January, 2022

Page: [2995 - 3027] Pages: 33

DOI: 10.2174/0929867328666211026120335


LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors.

Keywords: Cytoskeleton, thiazole, thienopyridine derivatives, thienopyrimidine, synthesis, LIM kinase.

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