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Current Chemical Biology


ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

Review Article

Natural Compounds as Heme Oxygenase-1 Inducers to Reduce the Deleterious Consequences Following SARS-CoV-2 Infection

Author(s): Valeria Sorrenti*, Valeria Consoli , Salvo Grosso S. and Luca Vanella

Volume 15, Issue 3, 2021

Published on: 11 October, 2021

Page: [205 - 214] Pages: 10

DOI: 10.2174/2212796815666211011142101

Price: $65


The virus SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) causes COVID 19 (CoronaVIrus Disease 19), a global pandemic with multi-organ failure, resulting in high morbidity and mortality. Some individuals are more vulnerable than others and have deleterious consequences following covid- 19. It has been postulated that Heme oxygenase-1 (HO-1) reduction and free heme may contribute to many of the inflammatory phenomena observed in COVID-19 patients. Therefore, HO-1 inducers could prove to be potential therapeutic or preventive agents for COVID 19. Many of the natural compounds present in fruits and vegetables, such as polyphenols, were able to induce HO-1. The aim of this review is to focus on the main foods containing bioactive compounds able to induce HO-1 for an informed choice of foods to use to counteract damage from SARS-CoV-2 infection.

Keywords: SARS-CoV-2, heme oxygenase-1, heme oxygenase-1 inducers, oxidative stress, natural compounds, food.

Graphical Abstract
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