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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Mini-Review Article

Aminoglycosides with Anti-MRSA Activity: A Concise Review

Author(s): Cheng-Jiao Yao, Yi-lin Li, Meng-Jun Pu, Li-Hong Luo, Qin Xiong, Feng-Jiao Xie, Ting-Lin Li and Pei-Min Feng*

Volume 21, Issue 27, 2021

Published on: 03 October, 2021

Page: [2483 - 2499] Pages: 17

DOI: 10.2174/1568026621666211004093647

Price: $65


Methicillin-resistant Staphylococcus aureus (MRSA), a leading cause of infections in human being and is usually associated with a multidrug-resistant profile, represents a significant health threat and public burden globally. The limited options of effective antibiotics motivate the search for novel anti-MRSA agents. Aminoglycoside antibiotics have been extensively applied in the medical field due to their desirable broad-spectrum antibacterial activity, especially for systemic infections caused by Gram-negative organisms. Recent studies demonstrated that aminoglycosides also possessed potential activity against MRSA, so aminoglycosides may be useful weapons to fight against MRSA. The present work aims to summarize the current scenario of aminoglycosides with anti- MRSA potential, covering articles published between 2010 and 2020. The structure-activity relationship and the mechanism of action are also discussed for the further rational design of novel potential drug candidates.

Keywords: Aminoglycosides, S. aureus, MRSA, Drug resistance, Gram-negative organisms, SAR.

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