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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections

Author(s): Shadma Wahab*, Irfan Ahmad, Safia Irfan, Ayesha Siddiqua, Shazia Usmani and Md. Parwez Ahmad

Volume 22, Issue 11, 2022

Published on: 10 January, 2022

Page: [1476 - 1494] Pages: 19

DOI: 10.2174/1389557521666210927153001

Price: $65


Respiratory tract infections are underestimated because they are mild and disabling, but in clinical medicine, these are the most prevalent problems. According to the World Health Organization third-most comprehensive cause of death in the world till 2030 would be Chronic Obstructive Pulmonary Disease (COPD). Dominating viruses of respiratory infections are influenza, respiratory syncytial virus, rhinoviruses, and human coronaviruses. Antibiotics are mostly used to treat bacterial infections, and they do not effectively manage viral infections like sinusitis, sore throats, bronchitis, influenza, and common respiratory infections. Presently no medication is available only symptomatic interventions is an option in our hand. However, a lot of research is going on the vaccine and drugs-based approaches against respiratory viruses worldwide. Traditional medicines are getting the attraction to treat many diseases. It is vital to screen the medicinal plants to find the potential of new compounds for treatment against antiviral and antimicrobial activities. Glycyrrhiza glabra L. (Licorice) pharmacological actions modulate the immune system, inhibit virus growth, produce anti-inflammatory activity, and inactivate viruses. This comprehensive review mainly focuses on the role of licorice in managing respiratory infections caused by viruses and bacteria, including complications associated with its excess intake. There has been limited human research’s exhibited licorice effectiveness in respiratory infections; therefore, there is a need for uncompromising and long-term research. This paper will be a valuable reference for biologists and physicians looking for a medication for respiratory infections. Glycyrrhiza glabra could open the door to novel agents in drug discovery and development.

Keywords: Glycyrrhizin, licorice, copd, respiratory infection, influenza, respiratory syncytial virus, rhinoviruses, human coronaviruses.

Graphical Abstract
Öztürk, M.; Altay, V.; Hakeem, K.R.; Akçiçek, E. Introduction; Springer: Cham, 2017, pp. 1-4.
Paolini, M.; Pozzetti, L.; Sapone, A.; Cantelli-Forti, G. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygena-ses. Life Sci., 1998, 62(6), 571-582.
[] [PMID: 9464470]
Armanini, D.; Bonanni, G.; Palermo, M. Reduction of serum testosterone in men by licorice. N. Engl. J. Med., 1999, 341(15), 1158.
[] [PMID: 10515764]
Armanini, D.; Bonanni, G.; Mattarello, M.J.; Fiore, C.; Sartorato, P.; Palermo, M. Licorice consumption and serum testosterone in healthy man. Exp. Clin. Endocrinol. Diabetes, 2003, 111(6), 341-343.
[] [PMID: 14520600]
Brickel, C. The Royal Horticultural Society, bicentenary edition. Encyclopedia of Gardening; Dorling Kindersley Limited, 2002.
Thomas, J. Herbal medicines. Aust. J. Pharm., 1997, 78, 1289-1293.
American Botanical Council. Expanded Commission E Monographs: Kava kava rhizome (root). Herb Med,. 2000, 1-8. (accessed December 22, 2020).
Chopra, PKPG; Gaitry Chopra, PKP; Saraf, BD; Inam, F. Deo, SS Antimicrobial and antioxidant activities of methanol extract roots of Glycyrrhiza glabra and HPLC analysis. Int. J. Pharm. Pharm. Sci., 2013.
Sultana, S.; Haque, A.; Hamid, K.; Fatima Urmi, K.; Roy, S. Antimicrobial, cytotoxic and antioxidant activity of methanolic extract of Gly-cyrrhiza glabra. Agric. Biol. J. N. Am., 2010.
Tang, W.; Eisenbrand, G. Panax ginseng C.A. Mey; Chinese Drugs Plant Orig; Springer Berlin Heidelberg, 1992, pp. 711-737.
Petramfar, P.; Hajari, F.; Yousefi, G.; Azadi, S.; Hamedi, A. Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson’s disease, A randomized double blinded clinical trial. J. Ethnopharmacol., 2020, 247, 112226.
[] [PMID: 31574343]
Eczema Symptoms & Causes | National Eczema Association n.d.. (accessed December 27, 2020).
Nasri, H.; Bahmani, M.; Shahinfard, N.; Moradi Nafchi, A.; Saberianpour, S.; Rafieian Kopaei, M. Medicinal plants for the treatment of acne vulgaris: A review of recent evidences. Jundishapur J. Microbiol., 2015, 8(11), e25580.
[] [PMID: 26862380]
Irani, M.; Sarmadi, M.; Bernard, F.; Ebrahimi Pour, G.H.; Shaker Bazarnov, H. Ebrahimi pour GH, Bazarnov HS. Leaves antimicrobial activity of Glycyrrhiza glabra L. Iran. J. Pharm. Res., 2010, 9(4), 425-428.
[] [PMID: 24381608]
Cellulitis | CDC n.d.. (accessed December 27, 2020).
Gupta, V.K.; Fatima, A.; Faridi, U.; Negi, A.S.; Shanker, K.; Kumar, J.K.; Rahuja, N.; Luqman, S.; Sisodia, B.S.; Saikia, D.; Darokar, M.P.; Khanuja, S.P. Antimicrobial potential of Glycyrrhiza glabra roots. J. Ethnopharmacol., 2008, 116(2), 377-380.
[] [PMID: 18182260]
Messier, C.; Epifano, F.; Genovese, S.; Grenier, D. Licorice and its potential beneficial effects in common oro-dental diseases. Oral Dis., 2012, 18(1), 32-39.
[] [PMID: 21851508]
Asl, M.N.; Hosseinzadeh, H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother. Res., 2008, 22(6), 709-724.
[] [PMID: 18446848]
Chen, H.J.; Kang, S.P.; Lee, I.J.; Lin, Y.L. Glycyrrhetinic acid suppressed NF-κB activation in TNF-α-induced hepatocytes. J. Agric. Food Chem., 2014, 62(3), 618-625.
[] [PMID: 24386942]
Fu, Y.; Chen, J.; Li, Y.J.; Zheng, Y.F.; Li, P. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chem., 2013, 141(2), 1063-1071.
[] [PMID: 23790887]
Simmler, C.; Pauli, G.F.; Chen, S.N. Phytochemistry and biological properties of glabridin. Fitoterapia, 2013, 90, 160-184.
[] [PMID: 23850540]
Nomura, T.; Fukai, T.; Akiyama, T. Chemistry of phenolic compounds of licorice (Glycyrrhiza species) and their estrogenic and cytotoxic activities. Pure Appl. Chem., 2002, 74, 1199-1206.
Nanahoshi, M. [Effect of glycyrrhizin on the action cortisone].. Nippon Naibunpi Gakkai Zasshi, 1967, 42(12), 1312-1319.
[] [PMID: 6067711]
Tohma, H.S.; Gulçin, I. Antioxidant and radical scavenging activity of aerial parts and roots of Turkish liquorice (Glycyrrhiza glabra L.). Int. J. Food Prop., 2010, 13, 657-671.
Rizzato, G.; Scalabrin, E.; Radaelli, M.; Capodaglio, G.; Piccolo, O. A new exploration of licorice metabolome. Food Chem., 2017, 221, 959-968.
[] [PMID: 27979300]
Shibata, S. A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi, 2000, 120(10), 849-862.
[] [PMID: 11082698]
Song, W.; Qiao, X.; Chen, K.; Wang, Y.; Ji, S.; Feng, J.; Li, K.; Lin, Y.; Ye, M. Biosynthesis-Based quantitative analysis of 151 secondary metabolites of licorice to differentiate medicinal Glycyrrhiza species and their hybrids. Anal. Chem., 2017, 89(5), 3146-3153.
[] [PMID: 28192986]
Lawless, J. The illustrated encyclopedia of essential oils: the complete guide to the use of oils in aromatherapy and herbalism.Element books,, 1995.
Isbrucker, R.A.; Burdock, G.A. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul. Toxicol. Pharmacol., 2006, 46(3), 167-192.
[] [PMID: 16884839]
Akamatsu, H.; Komura, J.; Asada, Y.; Niwa, Y. Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation. Planta Med., 1991, 57(2), 119-121.
[] [PMID: 1891493]
Graebin, C.S. The Pharmacological Activities of Glycyrrhizinic Acid (“Glycyrrhizin”) and Glycyrrhetinic Acid; Springer: Cham, 2016, pp. 1-17.
Obolentseva, G.V.; Litvinenko, V.I.; Ammosov, A.S.; Popova, T.P.; Sampiev, A.M. Pharmacological and therapeutic properties of licorice preparations (A review). Pharm. Chem. J., 1999, 33, 427-434.
Pastorino, G.; Cornara, L.; Soares, S.; Rodrigues, F.; Oliveira, M.B.P.P. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacolo-gical review. Phytother. Res., 2018, 32(12), 2323-2339.
[] [PMID: 30117204]
Gottlieb, D.; Shaw, P.D., Eds.; Mechanism of Action; Springer Berlin Heidelberg: Berlin, Heidelberg, 1967.
Anand David, A.V.; Arulmoli, R.; Parasuraman, S. Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacogn. Rev., 2016, 10(20), 84-89.
[] [PMID: 28082789]
Tavana, E.; Mollazadeh, H.; Mohtashami, E.; Modaresi, S.M.S.; Hosseini, A.; Sabri, H.; Soltani, A.; Javid, H.; Afshari, A.R.; Sahebkar, A. Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme. Biofactors, 2020, 46(3), 356-366.
[] [PMID: 31880372]
Nijveldt, R.J.; van Nood, E.; van Hoorn, D.E.; Boelens, P.G.; van Norren, K.; van Leeuwen, P.A. Flavonoids: A review of probable me-chanisms of action and potential applications. Am. J. Clin. Nutr., 2001, 74(4), 418-425.
[] [PMID: 11566638]
Yamamura, Y.; Kawakami, J.; Santa, T.; Kotaki, H.; Uchino, K.; Sawada, Y.; Tanaka, N.; Iga, T. Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method. J. Pharm. Sci., 1992, 81(10), 1042-1046.
[] [PMID: 1432618]
Kočevar Glavač N.; Kreft, S. Excretion profile of glycyrrhizin metabolite in human urine. Food Chem., 2012, 131, 305-308.
Yu, D.; Liu, X.; Zhang, G.; Ming, Z.; Wang, T. Isoliquiritigenin inhibits cigarette smoke-induced COPD by attenuating inflammation and oxidative stress via the regulation of the Nrf2 and NF-κB signaling pathways. Front. Pharmacol., 2018, 9, 1001.
[] [PMID: 30294270]
Kim, S.H.; Hong, J.H.; Yang, W.K.; Geum, J.H.; Kim, H.R.; Choi, S.Y.; Kang, Y.M.; An, H.J.; Lee, Y.C. Herbal combinational medication of glycyrrhiza glabra, agastache rugosa containing glycyrrhizic acid, tilianin inhibits neutrophilic lung inflammation by affecting cxcl2, in-terleukin17/stat3 signal pathways in a murine model of copd. Nutrients, 2020, 12(4), 926.
[] [PMID: 32230838]
Al-Jawad, F.; Al-Razzuqi, R.; Hashim, H.; Al-Bayati, N. Glycyrrhiza glabra versus Boswellia carterii in chronic bronchial asthma: A com-parative study of efficacy. Indian J. Allergy Asthma Immunol., 2012, 26, 6.
Udupa, N.; Khan, S.; Polu, P.; Nayanabhirama, U. Herbal medicinal plants as an anticancer agents Exploring newer pharmaceutical aids for safer, economic pharmaceutical dosage forms view project Herbal medicinal plants as an anticancer agents. Ann. Phytomed., 2015, 4, 37-45.
Gumpricht, E.; Dahl, R.; Devereaux, M.W.; Sokol, R.J. Licorice Compounds Glycyrrhizin and 18-Glycyrrhetinic Acid Are Potent Modula-tors of Bile Acid-induced Cytotoxicity in Rat Hepatocytes; ASBMB, 2005.
Shah, S.L.; Wahid, F.; Khan, N.; Farooq, U.; Shah, A.J.; Tareen, S.; Ahmad, F.; Khan, T. Inhibitory Effects of Glycyrrhiza glabra and Its Major Constituent Glycyrrhizin on Inflammation-Associated Corneal Neovascularization. Evid. Based Complement. Alternat. Med., 2018, 2018, 8438101.
[] [PMID: 29849730]
Kao, T.C.; Shyu, M.H.; Yen, G.C. Glycyrrhizic acid and 18β-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3β signaling and glucocorticoid receptor activation. J. Agric. Food Chem., 2010, 58(15), 8623-8629.
[] [PMID: 20681651]
J H. J L, P O, L Z. Glycyrrhizic acid mitigates 2nd round radiotherapy-Induced severe lung injury: A case report. J. Lung Dis. Treat., 2017, 03, 1-3.
Xie, Y.C.; Dong, X.W.; Wu, X.M.; Yan, X.F.; Xie, Q.M. Inhibitory effects of flavonoids extracted from licorice on lipopolysaccharide-induced acute pulmonary inflammation in mice. Int. Immunopharmacol., 2009, 9(2), 194-200.
[] [PMID: 19071231]
Ram, A.; Mabalirajan, U.; Das, M.; Bhattacharya, I.; Dinda, A.K.; Gangal, S.V.; Ghosh, B. Glycyrrhizin alleviates experimental allergic asthma in mice. Int. Immunopharmacol., 2006, 6(9), 1468-1477.
[] [PMID: 16846841]
Hocaoglu, A.B.; Karaman, O.; Erge, D.O.; Erbil, G.; Yilmaz, O.; Bagriyanik, A.; Uzuner, N. Glycyrrhizin and long-term histopathologic changes in a murine model of asthma. Curr. Ther. Res. Clin. Exp., 2011, 72(6), 250-261.
[] [PMID: 24648593]
Dogan, M.F.; Parlar, A.; Cam, S.A.; Tosun, E.M.; Uysal, F.; Arslan, S.O. Glabridin attenuates airway inflammation and hyperresponsive-ness in a mice model of ovalbumin-induced asthma. Pulm. Pharmacol. Ther., 2020, 63, 101936.
[] [PMID: 32783990]
Biological Effects of Quercetin in COPD. Case Med Res,. 2019.
Feng Yeh, C.; Wang, K.C.; Chiang, L.C.; Shieh, D.E.; Yen, M.H.; San Chang, J. Water extract of licorice had anti-viral activity against hu-man respiratory syncytial virus in human respiratory tract cell lines. J. Ethnopharmacol., 2013, 148(2), 466-473.
[] [PMID: 23643542]
Manti, S.; Harford, T.J.; Salpietro, C.; Rezaee, F.; Piedimonte, G. Induction of high-mobility group Box-1 in vitro and in vivo by respira-tory syncytial virus. Pediatr. Res., 2018, 83(5), 1049-1056.
[] [PMID: 29329282]
Wang, X.Q.; Li, H.Y.; Liu, X.Y.; Zhang, F.M.; Li, X.X.; Piao, Y.A. The anti-respiratory syncytial virus effect of active compound of Gly-cyrrhiza GD4 in vitro. Zhong Yao Cai, 2006, 29, 692-694.
Omer, M.O.; Almalki, W.H.; Shahid, I.; Khuram, S.; Altaf, I.; Imran, S. Comparative study to evaluate the anti-viral efficacy of Glycyrrhi-za glabra extract and ribavirin against the Newcastle disease virus. Pharmacognosy Res., 2014, 6(1), 6-11.
[] [PMID: 24497736]
Yamaya, M.; Sasaki, T.; Yasuda, H.; Inoue, D.; Suzuki, T.; Asada, M.; Yoshida, M.; Seki, T.; Iwasaki, K.; Nishimura, H.; Nakayama, K. Hochu-ekki-to inhibits rhinovirus infection in human tracheal epithelial cells. Br. J. Pharmacol., 2007, 150(6), 702-710.
[] [PMID: 17310142]
Yanagawa, Y.; Ogura, M.; Fujimoto, E.; Shono, S.; Okuda, E. Effects and cost of glycyrrhizin in the treatment of upper respiratory tract infections in members of the Japanese maritime self-defense force: Preliminary report of a prospective, randomized, double-blind, contro-lled, parallel-group, alternate-day treatment assignment clinical trial. Curr. Ther. Res. Clin. Exp., 2004, 65(1), 26-33.
[] [PMID: 24936101]
Influenza (Flu) | CDC 2019. (accessed May 4, 2021).
Pompei, R.; Paghi, L.; Ingianni, A.; Uccheddu, P. Glycyrrhizic acid inhibits influenza virus growth in embryonated eggs. Microbiologica, 1983, 6(3), 247-250.
[PMID: 6633273]
Utsunomiya, T.; Kobayashi, M.; Pollard, R.B.; Suzuki, F. Glycyrrhizin, an active component of licorice roots, reduces morbidity and mor-tality of mice infected with lethal doses of influenza virus. Antimicrob. Agents Chemother., 1997, 41(3), 551-556.
[] [PMID: 9055991]
Wolkerstorfer, A.; Kurz, H.; Bachhofner, N.; Szolar, O.H.J. Glycyrrhizin inhibits influenza A virus uptake into the cell. Antiviral Res., 2009, 83(2), 171-178.
[] [PMID: 19416738]
Razinkov, V.I.; Melikyan, G.B.; Epand, R.M.; Epand, R.F.; Cohen, F.S. Effects of spontaneous bilayer curvature on influenza virus-mediated fusion pores. J. Gen. Physiol., 1998, 112(4), 409-422.
[] [PMID: 9758860]
Harada, S. The broad anti-viral agent glycyrrhizin directly modulates the fluidity of plasma membrane and HIV-1 envelope. Biochem. J., 2005, 392(Pt 1), 191-199.
[] [PMID: 16053446]
Michaelis, M.; Geiler, J.; Naczk, P.; Sithisarn, P.; Leutz, A.; Doerr, H.W.; Cinatl, J. Jr Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression. PLoS One, 2011, 6(5), e19705.
[] [PMID: 21611183]
Wang, J.; Chen, X.; Wang, W.; Zhang, Y.; Yang, Z.; Jin, Y.; Ge, H.M.; Li, E.; Yang, G. Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. J. Ethnopharmacol., 2013, 147(1), 114-121.
[] [PMID: 23454684]
Wu, T.Y.; Khor, T.O.; Saw, C.L.L.; Loh, S.C.; Chen, A.I.; Lim, S.S.; Park, J.H.; Cai, L.; Kong, A.N. Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. AAPS J., 2011, 13(1), 1-13.
[] [PMID: 20967519]
Chen, X.X.; Zhou, H.X.; Qi, W.B.; Ning, Z.Y.; Ma, Y.J.; Li, Y.L.; Wang, G.C.; Chen, J.X. [Antiviral effects of the combination of glycyrrhizin and ribavirin against influenza A H1N1 virus infection in vivo]. Yao Xue Xue Bao,, 2015, 50(8), 966-972.
[PMID: 26668995]
Tsuji, M.; Sriwilaijaroen, N.; Inoue, H.; Miki, K.; Kinoshita, K.; Koyama, K.; Furuhata, K.; Suzuki, Y.; Takahashi, K. Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates. Bioorg. Med. Chem., 2018, 26(1), 17-24.
[] [PMID: 29198893]
Moisy, D.; Avilov, S.V.; Jacob, Y.; Laoide, B.M.; Ge, X.; Baudin, F.; Naffakh, N.; Jestin, J.L. HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication. J. Virol., 2012, 86(17), 9122-9133.
[] [PMID: 22696656]
Andersson, U.; Tracey, K.J. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol., 2011, 29, 139-162.
[] [PMID: 21219181]
(Centers for Disease Control and Prevention). RSV | Home | Respiratory Syncytial Virus | CDC. US Dep Heal Hum Serv 2017.. (accessed December 20, 2020).
Nam, H.H.; Ison, M.G. Respiratory syncytial virus infection in adults. BMJ, 2019, 366, l5021.
[] [PMID: 31506273]
Krause, C.I. The ABCs of RSV. Nurse Pract., 2018, 43(9), 20-26.
[] [PMID: 30134433]
Mação, P.; Dias, A.; Azevedo, L.; Jorge, A.; Rodrigues, C. [Acute bronchiolitis: a prospective study]. Acta Med. Port., 2011, 24(Suppl. 2), 407-412.
[] [PMID: 22849929]
Hatipoğlu, N.; Somer, A.; Badur, S.; Unüvar, E.; Akçay-Ciblak, M.; Yekeler, E.; Salman, N.; Keser, M.; Hatipoğlu, H.; Siraneci, R. Viral etiology in hospitalized children with acute lower respiratory tract infection. Turk. J. Pediatr., 2011, 53(5), 508-516.
[PMID: 22272450]
Shi, Y.; Wu, D.; Sun, Z.; Yang, J.; Chai, H.; Tang, L.; Guo, Y. Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. Phytother. Res., 2012, 26(9), 1410-1417.
[] [PMID: 22389128]
Bailly, C.; Vergoten, G. Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndro-me? Pharmacol. Ther., 2020, 214, 107618.
[] [PMID: 32592716]
Wahab, S.; Ahmad, I.; Usmani, S.; Ahmad, M.P. Epidemiological situation and efficacy of Dexamethasone for the treatment planning of COVID-19: A perspective review. Curr. Drug Deliv., 2020, 17.
[] [PMID: 33023445]
Wahab, S.; Ahmad, I.; Irfan, S.; Baig, M.H.; Farouk, A-E.; Dong, J-J. Use of natural compounds as a potential therapeutic agent against COVID-19. Curr. Pharm. Des., 2021, 27(9), 1144-1152.
[] [PMID: 33388014]
Chen, F.; Chan, K.H.; Jiang, Y.; Kao, R.Y.T.; Lu, H.T.; Fan, K.W.; Cheng, V.C.; Tsui, W.H.; Hung, I.F.; Lee, T.S.; Guan, Y.; Peiris, J.S.; Yuen, K.Y. In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds. J. Clin. Virol., 2004, 31(1), 69-75.
[] [PMID: 15288617]
Cinatl, J.; Morgenstern, B.; Bauer, G.; Chandra, P.; Rabenau, H.; Doerr, H.W. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet, 2003, 361(9374), 2045-2046.
[] [PMID: 12814717]
Fiore, C.; Eisenhut, M.; Krausse, R.; Ragazzi, E.; Pellati, D.; Armanini, D.; Bielenberg, J. Antiviral effects of Glycyrrhiza species. Phytother. Res., 2008, 22(2), 141-148.
[] [PMID: 17886224]
Matsui, S.; Matsumoto, H.; Sonoda, Y.; Ando, K.; Aizu-Yokota, E.; Sato, T.; Kasahara, T. Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line. Int. Immunopharmacol., 2004, 4(13), 1633-1644.
[] [PMID: 15454116]
Korenaga, M.; Hidaka, I.; Nishina, S.; Sakai, A.; Shinozaki, A.; Gondo, T.; Furutani, T.; Kawano, H.; Sakaida, I.; Hino, K. A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice. Liver Int., 2011, 31(4), 552-560.
[] [PMID: 21382166]
Ogiku, M.; Kono, H.; Hara, M.; Tsuchiya, M.; Fujii, H. Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 pro-duction by Kupffer cells after ischemia-reperfusion in rats. J. Pharmacol. Exp. Ther., 2011, 339(1), 93-98.
[] [PMID: 21737537]
Li, J.Y.; Cao, H.Y.; Liu, P.; Cheng, G.H.; Sun, M.Y. Glycyrrhizic acid in the treatment of liver diseases: Literature review. BioMed Res. Int., 2014, 2014, 872139.
[] [PMID: 24963489]
Mori, K.; Sakai, H.; Suzuki, S.; Akutsu, Y.; Ishikawa, M.; Imaizumi, M.; Tada, K.; Aihara, M.; Sawada, Y.; Yokoyama, M. Effects of gly-cyrrhizin (SNMC: Stronger Neo-Minophagen C) in hemophilia patients with HIV-1 infection. Tohoku J. Exp. Med., 1990, 162(2), 183-193.
[] [PMID: 2129071]
Ito, M.; Nakashima, H.; Baba, M.; Pauwels, R.; De Clercq, E.; Shigeta, S.; Yamamoto, N. Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus. [HIV (HTLV-III/LAV)]. Antiviral Res.,, 1987, 7(3), 127-137.
[] [PMID: 3475037]
Ito, M.; Sato, A.; Hirabayashi, K.; Tanabe, F.; Shigeta, S.; Baba, M.; De Clercq, E.; Nakashima, H.; Yamamoto, N. Mechanism of inhibi-tory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). Antiviral Res., 1988, 10(6), 289-298.
[] [PMID: 3250333]
Hatanaka, K.; Yoshida, T.; Uryu, T.; Yoshida, O.; Nakashima, H.; Yamamoto, N.; Mimura, T.; Kaneko, Y. Synthesis of an inhibitor of human immunodeficiency virus infection. Jpn. J. Cancer Res., 1989, 80(2), 95-98.
[] [PMID: 2498253]
Sasaki, H.; Takei, M.; Kobayashi, M.; Pollard, R.B.; Suzuki, F. Effect of glycyrrhizin, an active component of licorice roots, on HIV repli-cation in cultures of peripheral blood mononuclear cells from HIV-seropositive patients. Pathobiology, 2002-2003, 70(4), 229-236.
[] [PMID: 12679601]
Abe, N.; Ebina, T.; Ishida, N. Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice. Microbiol. Immunol., 1982, 26(6), 535-539.
[] [PMID: 6290851]
Ko, H.C.; Wei, B.L.; Chiou, W.F. The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by virus-infected human epithelial cells. J. Ethnopharmacol., 2006, 107(2), 205-210.
[] [PMID: 16621378]
Hoever, G.; Baltina, L.; Michaelis, M.; Kondratenko, R.; Baltina, L.; Tolstikov, G.A.; Doerr, H.W.; Cinatl, J., Jr Antiviral activity of gly-cyrrhizic acid derivatives against SARS-coronavirus. J. Med. Chem., 2005, 48(4), 1256-1259.
[] [PMID: 15715493]
Pompei, R.; Flore, O.; Marccialis, M.A.; Pani, A.; Loddo, B. Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature, 1979, 281(5733), 689-690.
[] [PMID: 233133]
Baba, M.; Shigeta, S. Antiviral activity of glycyrrhizin against varicella-zoster virus in vitro. Antiviral Res., 1987, 7(2), 99-107.
[] [PMID: 3034150]
Lampi, G.; Deidda, D.; Pinza, M.; Pompei, R. Enhancement of anti-herpetic activity of glycyrrhizic acid by physiological proteins. Antivir. Chem. Chemother., 2001, 12(2), 125-131.
[] [PMID: 11527044]
Lin, J.C. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. Antiviral Res., 2003, 59(1), 41-47.
[] [PMID: 12834859]
Numazaki, K.; Nagata, N.; Sato, T.; Chiba, S. Effect of glycyrrhizin, cyclosporin A, and tumor necrosis factor α on infection of U-937 and MRC-5 cells by human cytomegalovirus. J. Leukoc. Biol., 1994, 55(1), 24-28.
[] [PMID: 8283138]
Machida, H.; Nishitani, M.; Watanabe, Y.; Yoshimura, Y.; Kano, F.; Sakata, S. Comparison of the selectivity of anti-varicella-zoster virus nucleoside analogues. Microbiol. Immunol., 1995, 39(3), 201-206.
[] [PMID: 7603364]
Sekizawa, T.; Yanagi, K.; Itoyama, Y. Glycyrrhizin increases survival of mice with herpes simplex encephalitis. Acta Virol., 2001, 45(1), 51-54.
[PMID: 11394578]
Crance, J.M.; Biziagos, E.; Passagot, J.; van Cuyck-Gandré, H.; Deloince, R. Inhibition of hepatitis A virus replication in vitro by antiviral compounds. J. Med. Virol., 1990, 31(2), 155-160.
[] [PMID: 2167349]
Ayfer ATEfi D. Turgay ERDO Ö. Antimicrobial Activities of Various Medicinal and Commercial Plant Extracts T›bbi ve Ticari Amaçl› Kullan›lan Baz› Bitki Ekstraktlar›n›n Antimikrobiyal Etkileri; The Scientific and Technological Research Council of Turkey, 2003, p. 27.
Antioxidant determinations by the use of a stable free radical. Nature, 1958, 181, 1199-1200.
Karahan, F.; Avsar, C.; Ozyigit, I.I.; Berber, I. Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glanduli-fera from different habitats. Biotechnol. Biotechnol. Equip., 2016, 30, 797-804.
Shirazi, M.H.; Ranjbar, R.; Eshraghi, S.; Sadeghi, G.; Jonaidi, N.; Bazzaz, N. An evaluation of antibacterial activity of Glycyrrhiza glabra extract on the growth of Salmonella, Shigella and ETEC E. coli. J. Biol. Sci., 2007, 7, 827-829.
Sedighinia, F.; Safipour Afshar, A.; Soleimanpour, S.; Zarif, R.; Asili, J.; Ghazvini, K. Antibacterial activity of Glycyrrhiza glabra against oral pathogens: An in vitro study. Avicenna J. Phytomed., 2012, 2(3), 118-124.
[] [PMID: 25050240]
Jafari-Sales, A.; Bolouri, P. Evaluation of the antimicrobial effects of Glycyrrhiza glabra l. on some gram positive and gram negative pathogenic bacteria in laboratory conditions. Jorjani Biomed. J., 2018, 6, 78-84.
Geetha, R.V.; Anitha, R. In vitro evaluation of anti mycotic activity of ethanolic extract of Glycyrrhiza glabra. Asian J. Pharm. Clin. Res., 2013, 6, 205-206.
Iqbal, Z. Antioxidant and Antibacterial Activity of Organic Extracts of Roots of Glycyrrhiza Glabra Linn, 2017, 5(4), 68-72.
Nazari, S.; Rameshrad, M.; Hosseinzadeh, H. Toxicological effects of glycyrrhiza glabra (Licorice): A Review. Phytother. Res., 2017, 31(11), 1635-1650.
[] [PMID: 28833680]
Kwon, Y.J.; Son, D.H.; Chung, T.H.; Lee, Y.J. A review of the pharmacological efficacy and safety of licorice root from corroborative clinical trial findings. J. Med. Food, 2020, 23(1), 12-20.
[] [PMID: 31874059]
Farese, R.V., Jr; Biglieri, E.G.; Shackleton, C.H.L.; Irony, I.; Gomez-Fontes, R. Licorice-induced hypermineralocorticoidism. N. Engl. J. Med., 1991, 325(17), 1223-1227.
[] [PMID: 1922210]
Fraunfelder, F.W. Ocular side effects from herbal medicines and nutritional supplements. Am. J. Ophthalmol., 2004, 138(4), 639-647.
[] [PMID: 15488795]
Licorice: Side Effects, Dosages, Treatment, Interactions, Warnings n.d.. (accessed December 25, 2020).
Miyamoto, K.; Kawai, H.; Aoyama, R.; Watanabe, H.; Suzuki, K.; Suga, N.; Kitagawa, W.; Miura, N.; Nishikawa, K.; Imai, H. Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice. Clin. Exp. Nephrol., 2010, 14(2), 164-167.
[] [PMID: 19915794]
VITAL SIGNS: CAUSE AND EFFECT; Libido Loss? Don’t Blame Licorice - The New York Times n.d.. (accessed December 26, 2020).
Hasegawa, J.; Suyama, Y.; Kinugawa, T.; Morisawa, T.; Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardio-myopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. Cardiovasc. Drugs Ther., 1998, 12(6), 599-600.
[] [PMID: 10410830]
Conn, J.W.; Rovner, D.R.; Cohen, E.L. Licorice-induced pseudoaldosteronism. Hypertension, hypokalemia, aldosteronopenia, and suppressed plasma renin activity. JAMA, 1968, 205(7), 492-496.
[] [PMID: 5695305]
Chamberlain, J.J.; Abolnik, I.Z. Pulmonary edema following a licorice binge. West. J. Med., 1997, 167(3), 184-185.
[PMID: 9308417]
van der Zwan, A. Hypertension encephalopathy after liquorice ingestion. Clin. Neurol. Neurosurg., 1993, 95(1), 35-37.
[] [PMID: 8453813]
Dobbins, K.R.B.; Saul, R.F. Transient visual loss after licorice ingestion. J. Neuroophthalmol., 2000, 20(1), 38-41.
[] [PMID: 10770507]
Santaella, R.M.; Fraunfelder, F.W. Ocular adverse effects associated with systemic medications: Recognition and management. Drugs, 2007, 67(1), 75-93.
[] [PMID: 17209665]
Hall, R.C.; Clemett, R.S. Central retinal vein occlusion associated with liquorice ingestion. Clin. Exp. Ophthalmol., 2004, 32(3), 341-341.
[] [PMID: 15180854]
Schulze zur Wiesch, C.; Sauer, N.; Aberle, J. Hypertonus und Hypokaliämie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom. Dtsch. Med. Wochenschr., 2011, 136(17), 882-884.
[] [PMID: 21523638]
Ruiz-Granados, E.S.; Shouls, G.; Sainsbury, C.; Antonios, T. A salty cause of severe hypertension. BMJ Case Rep., 2012, 2012, bcr1220115336.
[] [PMID: 22665565]
Harahap, I.S.K.; Sasaki, N. Gunadi.; Yusoff, S.; Lee, M.J.; Morikawa, S. Herbal medicine containing licorice may be contraindicated for a patient with an HSD11B2 mutation. Evid. Based Complement. Alternat. Med., 2011, 2011, 646540.
Han, R.P.; Hwu, Y-J.; Peng, N-H.; Tseng, K-Y.; Pai, L-W.; Chiu, S.C. Effectiveness of Vitamin B12 on Recurrent Aphthous Stomatitis in long term care: A Systematic Review. JBI Library Syst. Rev., 2010, 8(34)(Suppl.), 1-15.
[] [PMID: 27820363]
Yang, R.; Yuan, B.C.; Ma, Y.S.; Zhou, S.; Liu, Y. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm. Biol., 2017, 55(1), 5-18.
[] [PMID: 27650551]
Touyz, L.Z.G. Liquorice health check, Oro-dental implications, and a case report. Case Rep. Med., 2009, 2009, 170735.
[] [PMID: 19707475]
Yasue, H.; Itoh, T.; Mizuno, Y.; Harada, E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hy-pertensive patient taking herbal medicines containing licorice. Intern. Med., 2007, 46(9), 575-578.
[] [PMID: 17473492]
Sidhu, P.; Shankargouda, S.; Rath, A.; Hesarghatta Ramamurthy, P.; Fernandes, B.; Kumar Singh, A. Therapeutic benefits of liquorice in dentistry. J. Ayurveda Integr. Med., 2020, 11(1), 82-88.
[] [PMID: 30391123]
Ye, X.G.; Su, Q.M. Effects of entecavir and lamivudine for hepatitis B decompensated cirrhosis: Meta-analysis. World J. Gastroenterol., 2013, 19(39), 6665-6678.
[] [PMID: 24151397]
Kraus, S.D. Glycyrrhizin-induced inhibition of the pituitary-adrenal stress response. J. Exp. Med., 1958, 108(3), 325-328.
[] [PMID: 13575669]
Nonnamaker, B.J. greger JL. Effect of ammoniated glycyrrhizin on the mineral utilization of rats. J. Food Sci., 1979, 44, 1558-1559.
Finney, R.S.H.; Somers, G.F.; Wilkinson, J.H. The pharmacological properties of glycyrrhetinic acid; a new anti-inflammatory drug. J. Pharm. Pharmacol., 1958, 10(11), 687-695.
[] [PMID: 13599102]
Ruszymah, B.H.I.; Nabishah, B.M.; Aminuddin, S.; Khalid, B.A.K. Effects of glycyrrhizic acid on right atrial pressure and pulmonary vasculature in rats. Clin. Exp. Hypertens., 1995, 17(3), 575-591.
[] [PMID: 7613529]
Radhakrishnan, N.; Phil, M.; Gnanamani, A.; Sadulla, S. Effect of Licorice (Glycyhrriza glabra Linn.), a skin-whitening agent on Black molly (Poecilia latipinnaa). J. Appl. Cosmetol., 2005, 23, 149-158.
Nourazarian, S.M.; Nourazarian, A.; Majidinia, M.; Roshaniasl, E. Effect of root extracts of medicinal herb Glycyrrhiza glabra on HSP90 gene expression and apoptosis in the HT-29 colon cancer cell line. Asian Pac. J. Cancer Prev., 2015, 16(18), 8563-8566.
[] [PMID: 26745117]
Schröder, T.; Hubold, C.; Muck, P.; Lehnert, H.; Haas, C.S. A hypertensive emergency with acute visual impairment due to excessive liquorice consumption. Neth. J. Med., 2015, 73(2), 82-85.
[PMID: 25753073]

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