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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Research Article

Is Fibromyalgia Associated with Borrelia-specific T Lymphocytes?

Author(s): Basant K. Puri*, Gary S. Lee and Armin Schwarzbach

Volume 18, Issue 2, 2022

Published on: 24 September, 2021

Page: [157 - 159] Pages: 3

DOI: 10.2174/1573397117666210924152636

Price: $65


Background: Although fibromyalgia is a common cause of chronic musculoskeletal pain, its aetiology and pathophysiology are uncertain. It has recently been suggested that fibromyalgia symptomatology represents a T lymphocyte-mediated immune response to pathogens, which are known risk factors for autoimmune diseases. One major suggested candidate pathogen is the bacterial genus Borrelia. However, to date, this hypothesis has not been tested.

Objective: The aim was to carry out the first test of this hypothesis by comparing Borrelia-specific T lymphocyte reactivity in fibromyalgia patients and matched controls.

Methods: The enzyme-linked immunospot assay was used to detect T-lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen), outer surface protein (Osp) A from Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, native OspC plus decorin binding protein A recombinant and lymphocyte function antigen-1 (shared epitope) in 27 patients who fulfilled the revised diagnostic criteria for fibromyalgia of the American College of Rheumatology and in 26 control subjects. The assays were carried out blind to the group status of the participants.

Results: The two groups did not differ by age, sex or ethnicity. They did not differ significantly in respect of T lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen) (p = 0.847), Osp mix (p = 0.709) or lymphocyte function antigen-1 (p = 0.367).

Conclusion: This novel controlled study provides no evidence of an association between fibromyalgia and Borrelia-specific T lymphocytes.

Keywords: Fibromyalgia, T lymphocytes, Borrelia, immune response, autoimmune disease, enzyme-linked immunospot assay.

Graphical Abstract
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