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Current Gene Therapy


ISSN (Print): 1566-5232
ISSN (Online): 1875-5631


Reduced Immunogenicity of Intraparenchymal Delivery of Adeno- Associated Virus Serotype 2 Vectors: Brief Overview

(E-pub Ahead of Print)
Author(s): Wuh-Liang Hwu, Shin-Ichi Muramatsu* and Bruria Gidoni-Ben-Zeev

DOI: 10.2174/1566523221666210922155413

open access plus


Pre existing immunity to adeno-associated virus (AAV) poses a concern in AAV vector– mediated gene therapy. Localized administration of low doses of carefully chosen AAV serotypes can mitigate the risk of an immune response. This article will illustrate the low risk of immune response to AAV serotype 2 vector–mediated gene therapy to the brain with support from clinical trial data in aromatic L-amino acid decarboxylase deficiency and Parkinson disease.

Keywords: Adeno-associated virus, aromatic L-amino acid decarboxylase deficiency, eladocagene exuparvovec, immunogenicity, vectors, rare disease

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