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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

A Systematic Review on Synthetic and Antimicrobial Bioactivity of the Multifaceted Hydrazide Derivatives

Author(s): Afrin Ansari, Savita Tauro and Sahaya Asirvatham*

Volume 19, Issue 4, 2022

Published on: 20 September, 2021

Page: [522 - 543] Pages: 22

DOI: 10.2174/1570193X18666210920141351

Price: $65

Abstract

To overcome the upsurge of antimicrobial resistance that has emerged in recent years, there is a need for the development of newer hits having satisfying anti-infective activity. Hydrazides incorporated with an azomethine hydrogen account for a cardinal class of molecules for the development of newer derivatives. Hydrazide derivatives have gained considerable interest of medicinal chemists owing to their diverse bioactivity. In the present review, we have attempted to compile the recent trends in the synthesis of hydrazides and their substituted derivatives. The structural features that lead to the desired antimicrobial activity are highlighted, which will lead the way for synthetic and medicinal chemists to focus on newer designs in this arena.

Keywords: Antimicrobial, hydrazide, hydrazone, anticonvulsant, minimum inhibitory concentration, diverse bioactivity.

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