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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Neuroprotective Effects of Neuropeptide Y against Neurodegenerative Disease

Author(s): Stéphanie Pain, Sébastien Brot and Afsaneh Gaillard*

Volume 20, Issue 9, 2022

Published on: 24 March, 2022

Page: [1717 - 1725] Pages: 9

DOI: 10.2174/1570159X19666210906120302

Price: $65


Neuropeptide Y (NPY), a 36 amino acid peptide, is widely expressed in the mammalian brain. Changes in NPY levels in different brain regions and plasma have been described in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, and Machado-Joseph disease. The changes in NPY levels may reflect the attempt to set up an endogenous neuroprotective mechanism to counteract the degenerative process. Accumulating evidence indicates that NPY can function as an anti-apoptotic, anti-inflammatory, and pro-phagocytic agent, which may be used effectively to halt or to slow down the progression of the disease. In this review, we will focus on the neuroprotective roles of NPY in several neuropathological conditions, with a particular focus on the anti-inflammatory properties of NPY.

Keywords: Neuropeptide Y, neurodegenerative disease, neuroprotection, neuroinflammation, apoptosis, autophagy.

Graphical Abstract
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