Generic placeholder image

Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Perspective

Lewy Body Pathology: From Amyloidosis to Vesicle Trafficking

Author(s): Faisal Nabi and Rizwan Hasan Khan*

Volume 28, Issue 11, 2021

Published on: 03 September, 2021

Page: [1203 - 1204] Pages: 2

DOI: 10.2174/0929866528666210903160048

Next »
[1]
Tanei, Z-I.; Saito, Y.; Ito, S.; Matsubara, T.; Motoda, A.; Yamazaki, M.; Sakashita, Y.; Kawakami, I.; Ikemura, M.; Tanaka, S.; Sengoku, R.; Arai, T.; Murayama, S. Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases. Acta Neuropathol., 2021, 141(1), 25-37.
[2]
He, S.; Wang, F.; Yung, K.K.L.; Zhang, S.; Qu, S. Effects of α-Synuclein-associated post-translational modifications in Parkinson’s disease. ACS Chem. Neurosci., 2021, 12(7), 1061-1071.
[3]
Araki, K.; Yagi, N.; Aoyama, K.; Choong, C-J.; Hayakawa, H.; Fujimura, H.; Nagai, Y.; Goto, Y.; Mochizuki, H. Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein. Proc. Natl. Acad. Sci. USA, 2019, 116(36), 17963-17969.
[4]
Reyes, J.F.; Sackmann, C.; Hoffmann, A.; Svenningsson, P.; Winkler, J.; Ingelsson, M.; Hallbeck, M. Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes. Acta Neuropathol., 2019, 138(1), 23-47.
[5]
Musgrove, R.E.; Helwig, M.; Bae, E-J.; Aboutalebi, H.; Lee, S-J.; Ulusoy, A.; Di Monte, D.A. Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer. J. Clin. Invest., 2019, 129(9), 3738-3753.
[6]
Guerrero-Ferreira, R.; Taylor, N.M.I.; Mona, D.; Ringler, P.; Lauer, M.E.; Riek, R.; Britschgi, M.; Stahlberg, H. Cryo-EM structure of alpha-synuclein fibrils. eLife, 2018, 7e36402
[http://dx.doi.org/10.7554/elife.36402]
[7]
Li, B.; Ge, P.; Murray, K.A.; Sheth, P.; Zhang, M.; Nair, G.; Sawaya, M.R.; Shin, W.S.; Boyer, D.R.; Ye, S.; Eisenberg, D.S.; Zhou, Z.H.; Jiang, L. Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel. Nat. Commun., 2018, 9(1), 3609.
[8]
Sorrentino, Z.A.; Giasson, B.I.; Chakrabarty, P. α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease. Acta Neuropathol., 2019, 138(1), 1-21.
[9]
Theillet, F-X.; Binolfi, A.; Bekei, B.; Martorana, A.; Rose, H.M.; Stuiver, M.; Verzini, S.; Lorenz, D.; van Rossum, M.; Goldfarb, D.; Selenko, P. Structural disorder of monomeric α-synuclein persists in mammalian cells. Nature, 2016, 530(7588), 45-50.
[10]
Pujols, J.; Peña-Díaz, S.; Lázaro, D.F.; Peccati, F.; Pinheiro, F.; González, D.; Carija, A.; Navarro, S.; Conde-Giménez, M.; García, J.; Guardiola, S.; Giralt, E.; Salvatella, X.; Sancho, J.; Sodupe, M.; Outeiro, T.F.; Dalfó, E.; & Ventura, S. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc. Natl. Acad. Sci. USA, 2018, 115(41), 10481-10486.
[11]
Shahmoradian, S.H.; Lewis, A.J.; Genoud, C.; Hench, J.; Moors, T.E.; Navarro, P.P.; Castaño-Díez, D.; Schweighauser, G.; Graff-Meyer, A.; Goldie, K.N.; Sütterlin, R.; Huisman, E.; Ingrassia, A.; Gier, Y. de,; Rozemuller, A.J.M.; Wang, J.; Paepe, A.D.; Erny, J.; Staempfli, A.; Lauer, M.E. Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes. Nat. Neurosci., 2019, 22(7), 1099-1109.
[12]
Ray, S.; Singh, N.; Kumar, R.; Patel, K.; Pandey, S.; Datta, D.; Mahato, J.; Panigrahi, R.; Navalkar, A.; Mehra, S.; Gadhe, L.; Chatterjee, D.; Sawner, A.S.; Maiti, S.; Bhatia, S.; Gerez, J.A.; Chowdhury, A.; Kumar, A.; Padinhateeri, R.; Riek, R.; Krishnamoorthy, G.; Maji, S.K. α-Synuclein aggregation nucleates through liquid-liquid phase separation. Nat. Chem., 2020, 12(8), 705-716.

© 2024 Bentham Science Publishers | Privacy Policy