Abstract
In the last few decades, major knowledge has been gained about pathophysiological aspects and molecular pathways behind Parkinson’s Disease (PD). Based on neurotoxicological studies and postmortem investigations, there is a general concept of how environmental toxicants (neurotoxins, pesticides, insecticides) and genetic factors (genetic mutations in PD-associated proteins) cause depletion of dopamine from substantia nigra pars compacta region of the midbrain and modulate cellular processes leading to the pathogenesis of PD. α-Synuclein, a neuronal protein accumulation in oligomeric form, called protofibrils, is associated with cellular dysfunction and neuronal death, thus possibly contributing to PD propagation. With advances made in identifying loci that contribute to PD, molecular pathways involved in disease pathogenesis are now clear, and introducing therapeutic strategy at the right time may delay the progression. Biomarkers for PD have helped monitor PD progression; therefore, personalized therapeutic strategies can be facilitated. In order to further improve PD diagnostic and prognostic accuracy, independent validation of biomarkers is required.
Keywords: Neurodegenerative diseases, α-Synuclein, Parkinson’s disease, dopamine, prognostic, therapeutic strategy.
[http://dx.doi.org/10.1016/j.jalz.2011.02.004] [PMID: 21414557]
[http://dx.doi.org/10.1177/0891988710383572] [PMID: 20938043]
[http://dx.doi.org/10.1111/apha.12515] [PMID: 25912260]
[http://dx.doi.org/10.1038/nsmb.2006] [PMID: 21278757]
[http://dx.doi.org/10.1016/S1097-2765(04)00151-0] [PMID: 15068806]
[http://dx.doi.org/10.1016/S0959-440X(99)00049-4] [PMID: 10679462]
[http://dx.doi.org/10.1146/annurev.biochem.75.101304.123901] [PMID: 16756495]
[http://dx.doi.org/10.1016/j.cell.2007.10.047] [PMID: 18160044]
[http://dx.doi.org/10.1016/j.molcel.2010.10.001] [PMID: 20965419]
[http://dx.doi.org/10.4161/auto.7.11.17661] [PMID: 21997368]
[http://dx.doi.org/10.1016/j.molcel.2010.09.023] [PMID: 20965422]
[http://dx.doi.org/10.1038/nature04724] [PMID: 16625204]
[http://dx.doi.org/10.1038/nrd2272] [PMID: 17396135]
[http://dx.doi.org/10.1146/annurev-pathol-011110-130242] [PMID: 21034221]
[http://dx.doi.org/10.1073/pnas.95.11.6469] [PMID: 9600990]
[http://dx.doi.org/10.3233/JPD-130230] [PMID: 24252804]
[http://dx.doi.org/10.1176/jnp.14.2.223] [PMID: 11983801]
[http://dx.doi.org/10.1016/S1474-4422(18)30295-3] [PMID: 30287051]
[http://dx.doi.org/10.1212/01.wnl.0000341769.50075.bb] [PMID: 19188574]
[http://dx.doi.org/10.1016/S1474-4422(18)30355-7] [PMID: 30287052]
[http://dx.doi.org/10.1016/j.ncl.2016.06.012] [PMID: 27720003]
[http://dx.doi.org/10.1159/000110368] [PMID: 8015664]
[http://dx.doi.org/10.1159/000080090] [PMID: 15297791]
[PMID: 17015930]
[http://dx.doi.org/10.1001/archneur.1988.00520360039008] [PMID: 3264148]
[http://dx.doi.org/10.1196/annals.1427.023] [PMID: 19076434]
[http://dx.doi.org/10.1007/s12035-012-8280-y] [PMID: 22622968]
[http://dx.doi.org/10.1038/42166] [PMID: 9278044]
[http://dx.doi.org/10.1016/S0002-9440(10)64553-1] [PMID: 10934145]
[http://dx.doi.org/10.1074/jbc.M208641200] [PMID: 12551928]
[http://dx.doi.org/10.3233/JAD-2004-6412] [PMID: 15345814]
[http://dx.doi.org/10.1002/syn.20719] [PMID: 19924695]
[http://dx.doi.org/10.1289/ehp.7573] [PMID: 16140634]
[http://dx.doi.org/10.1016/j.mcp.2016.11.001] [PMID: 27818248]
[http://dx.doi.org/10.1016/j.pneurobio.2011.03.005] [PMID: 21439347]
[http://dx.doi.org/10.1016/j.tig.2015.01.004] [PMID: 25703649]
[http://dx.doi.org/10.1111/ane.12563] [PMID: 26869347]
[http://dx.doi.org/10.1126/science.274.5290.1197] [PMID: 8895469]
[http://dx.doi.org/10.1002/ana.10795] [PMID: 14755719]
[http://dx.doi.org/10.1038/ng0298-106] [PMID: 9462735]
[http://dx.doi.org/10.1212/WNL.0b013e31828727ba] [PMID: 23427326]
[http://dx.doi.org/10.1002/ana.23894] [PMID: 23526723]
[http://dx.doi.org/10.1002/mds.26615] [PMID: 27028329]
[http://dx.doi.org/10.1002/mds.25499] [PMID: 23674458]
[http://dx.doi.org/10.1126/science.1090278] [PMID: 14593171]
[http://dx.doi.org/10.1212/01.wnl.0000271080.53272.c7] [PMID: 17625105]
[http://dx.doi.org/10.1002/mds.22682] [PMID: 19562770]
[http://dx.doi.org/10.1016/j.parkreldis.2013.07.011] [PMID: 23916651]
[http://dx.doi.org/10.1002/mds.25421] [PMID: 23457019]
[http://dx.doi.org/10.1002/mds.25502] [PMID: 23674490]
[http://dx.doi.org/10.1016/j.parkreldis.2009.09.008] [PMID: 19833540]
[http://dx.doi.org/10.1002/humu.21007] [PMID: 19405094]
[http://dx.doi.org/10.1097/00005072-199603000-00001] [PMID: 8786384]
[http://dx.doi.org/10.1172/JCI43366] [PMID: 21245577]
[http://dx.doi.org/10.1002/mds.23670] [PMID: 21469206]
[http://dx.doi.org/10.1039/c1ib00018g] [PMID: 22076255]
[http://dx.doi.org/10.1136/jnnp-2016-314857] [PMID: 28550072]
[http://dx.doi.org/10.1016/j.expneurol.2008.04.004] [PMID: 18511044]
[http://dx.doi.org/10.1093/brain/awr015] [PMID: 21349902]
[http://dx.doi.org/10.1111/jnc.14965] [PMID: 31957016]
[http://dx.doi.org/10.1016/j.celrep.2016.12.023] [PMID: 28052246]
[http://dx.doi.org/10.1111/jnc.14810] [PMID: 31269263]
[http://dx.doi.org/10.1073/pnas.1903054116] [PMID: 31110014]
[http://dx.doi.org/10.1242/jcs.157867] [PMID: 25967550]
[http://dx.doi.org/10.1016/j.tins.2010.09.004] [PMID: 20961626]
[http://dx.doi.org/10.1038/srep33289] [PMID: 27628239]
[http://dx.doi.org/10.1091/mbc.e08-03-0302] [PMID: 19553474]
[http://dx.doi.org/10.1111/j.1460-9568.2007.05757.x] [PMID: 17714497]
[http://dx.doi.org/10.1016/j.brainres.2011.01.064] [PMID: 21276428]
[http://dx.doi.org/10.1007/s10571-007-9227-0] [PMID: 17985233]
[http://dx.doi.org/10.1016/j.neuron.2004.11.005] [PMID: 15541309]
[http://dx.doi.org/10.1002/mds.26647] [PMID: 27126091]
[http://dx.doi.org/10.1002/ana.20456] [PMID: 15852371]
[http://dx.doi.org/10.1016/S0140-6736(05)17829-5] [PMID: 15680456]
[http://dx.doi.org/10.1007/s12031-011-9696-y] [PMID: 22194196]
[http://dx.doi.org/10.1016/S1474-4422(08)70117-0] [PMID: 18539534]
[http://dx.doi.org/10.1212/WNL.0b013e318227042d] [PMID: 21753163]
[http://dx.doi.org/10.1016/j.parkreldis.2009.11.004] [PMID: 19945904]
[http://dx.doi.org/10.1002/ana.20256] [PMID: 15349860]
[http://dx.doi.org/10.1093/brain/awl005] [PMID: 16401616]
[http://dx.doi.org/10.1001/archneur.61.12.1898] [PMID: 15596610]
[http://dx.doi.org/10.1212/01.WNL.0000142258.29304.FE] [PMID: 15505170]
[http://dx.doi.org/10.1212/01.wnl.0000167546.39375.82] [PMID: 16009891]
[http://dx.doi.org/10.3233/JPD-160989] [PMID: 27911343]
[http://dx.doi.org/10.1212/WNL.0000000000002744] [PMID: 27164705]
[http://dx.doi.org/10.1002/humu.22117] [PMID: 22581678]
[http://dx.doi.org/10.1212/WNL.0b013e3181e0f79c] [PMID: 20513816]
[http://dx.doi.org/10.1089/ars.2011.4105] [PMID: 21668405]
[http://dx.doi.org/10.1523/JNEUROSCI.0984-06.2006] [PMID: 16687518]
[http://dx.doi.org/10.1093/hmg/ddi413] [PMID: 16278233]
[PMID: 19050041]
[http://dx.doi.org/10.1016/S0140-6736(05)60746-5] [PMID: 9802278]
[http://dx.doi.org/10.1001/archneurol.2010.95] [PMID: 20558392]
[http://dx.doi.org/10.1002/mds.26357] [PMID: 26359782]
[http://dx.doi.org/10.1007/s00441-016-2485-8] [PMID: 27586587]
[http://dx.doi.org/10.1002/mds.20234] [PMID: 15390068]
[http://dx.doi.org/10.1002/ana.20587] [PMID: 16130111]
[http://dx.doi.org/10.1093/brain/awg136] [PMID: 12764050]
[http://dx.doi.org/10.1159/000503421] [PMID: 31618739]
[http://dx.doi.org/10.1073/pnas.240347797] [PMID: 11078524]
[http://dx.doi.org/10.1083/jcb.200809125] [PMID: 19029340]
[http://dx.doi.org/10.1086/322996] [PMID: 11462174]
[http://dx.doi.org/10.1002/mds.25132] [PMID: 22956510]
[http://dx.doi.org/10.1002/mds.20131] [PMID: 15254937]
[http://dx.doi.org/10.1007/s00401-004-0834-2] [PMID: 14991385]
[http://dx.doi.org/10.2174/156652407782564426] [PMID: 18045143]
[http://dx.doi.org/10.1016/j.bbrc.2006.05.011] [PMID: 16707095]
[http://dx.doi.org/10.1016/j.neulet.2007.08.010] [PMID: 17720313]
[http://dx.doi.org/10.1038/srep00954] [PMID: 23233873]
[http://dx.doi.org/10.1016/j.ajhg.2011.06.001] [PMID: 21763482]
[http://dx.doi.org/10.1212/WNL.0b013e318253d5f2] [PMID: 22517097]
[http://dx.doi.org/10.1002/mds.25145] [PMID: 22991136]
[http://dx.doi.org/10.1073/pnas.1814909116] [PMID: 30842285]
[http://dx.doi.org/10.1093/hmg/ddx179] [PMID: 28482024]
[http://dx.doi.org/10.1016/j.ajhg.2011.06.008] [PMID: 21763483]
[http://dx.doi.org/10.1136/jmedgenet-2012-101155] [PMID: 23125461]
[http://dx.doi.org/10.1038/ejhg.2010.254] [PMID: 21248740]
[http://dx.doi.org/10.1038/ng.485] [PMID: 19915576]
[http://dx.doi.org/10.1007/s00439-008-0582-9] [PMID: 18985386]
[http://dx.doi.org/10.1038/ng.642] [PMID: 20711177]
[http://dx.doi.org/10.1007/s004150200032] [PMID: 11967646]
[http://dx.doi.org/10.1002/mds.20279] [PMID: 15384126]
[http://dx.doi.org/10.1016/j.parkreldis.2018.01.008] [PMID: 29336905]
[http://dx.doi.org/10.1186/s40035-017-0086-4] [PMID: 28638597]
[http://dx.doi.org/10.3389/fneur.2018.00121] [PMID: 29568281]
[http://dx.doi.org/10.3390/brainsci9090239] [PMID: 31540441]
[http://dx.doi.org/10.1016/j.nbd.2011.12.041] [PMID: 22245219]
[http://dx.doi.org/10.1002/1531-8257(199901)14:1<117::AID-MDS1019>3.0.CO;2-0] [PMID: 9918353]
[http://dx.doi.org/10.1007/BF01663632] [PMID: 1185162]
[http://dx.doi.org/10.1002/mds.21803] [PMID: 17987654]
[http://dx.doi.org/10.1002/mds.21765] [PMID: 17973326]
[http://dx.doi.org/10.1002/mds.26112] [PMID: 25600157]
[http://dx.doi.org/10.1016/j.neulet.2016.09.042] [PMID: 27721206]
[http://dx.doi.org/10.1093/brain/awh445] [PMID: 15716302]
[http://dx.doi.org/10.1007/s00259-012-2232-7] [PMID: 22976499]
[http://dx.doi.org/10.1002/mds.21956] [PMID: 18307261]
[http://dx.doi.org/10.1212/WNL.49.6.1570] [PMID: 9409348]
[http://dx.doi.org/10.1523/JNEUROSCI.23-15-06351.2003] [PMID: 12867520]
[http://dx.doi.org/10.1111/j.1468-1331.2012.03836.x] [PMID: 22900781]
[http://dx.doi.org/10.1176/jnp.7.1.23] [PMID: 7711487]
[http://dx.doi.org/10.1007/s00415-014-7498-1] [PMID: 25228003]
[http://dx.doi.org/10.1016/S0197-4580(02)00065-9] [PMID: 12498954]
[http://dx.doi.org/10.1002/mds.24061] [PMID: 22237755]
[http://dx.doi.org/10.1002/mds.25904] [PMID: 24817690]
[http://dx.doi.org/10.1136/jnnp-2013-306439] [PMID: 24218528]
[http://dx.doi.org/10.1093/brain/awt067] [PMID: 23543483]
[http://dx.doi.org/10.1016/S0028-3932(02)00108-2] [PMID: 12417456]
[http://dx.doi.org/10.1016/S0140-6736(89)92366-0] [PMID: 2566813]
[http://dx.doi.org/10.1007/BF02257619] [PMID: 1347219]
[http://dx.doi.org/10.1016/j.neuint.2017.03.023] [PMID: 28408307]
[http://dx.doi.org/10.1111/j.1471-4159.1989.tb09133.x] [PMID: 2911023]
[http://dx.doi.org/10.1046/j.1471-4159.1998.70010268.x] [PMID: 9422371]
[http://dx.doi.org/10.1046/j.1471-4159.1997.69031196.x] [PMID: 9282943]
[http://dx.doi.org/10.1002/ana.410360305] [PMID: 8080242]
[http://dx.doi.org/10.1126/science.6823561] [PMID: 6823561]
[http://dx.doi.org/10.1038/311464a0] [PMID: 6332988]
[http://dx.doi.org/10.1016/j.ncl.2014.09.010] [PMID: 25432720]
[http://dx.doi.org/10.1038/nn.3489] [PMID: 23933751]
[http://dx.doi.org/10.1111/j.1751-1097.1997.tb08605.x] [PMID: 9077142]
[http://dx.doi.org/10.1016/S0002-9440(10)65396-5] [PMID: 10329595]
[http://dx.doi.org/10.1093/brain/awh198] [PMID: 15215212]
[http://dx.doi.org/10.1212/01.WNL.0000154597.24838.6B] [PMID: 15781836]
[http://dx.doi.org/10.1523/JNEUROSCI.21-24-09519.2001] [PMID: 11739563]
[http://dx.doi.org/10.1523/JNEUROSCI.0096-06.2006] [PMID: 16837598]
[http://dx.doi.org/10.1038/ncb1644] [PMID: 17906618]
[http://dx.doi.org/10.1016/j.bbrc.2005.04.124] [PMID: 15896322]
[http://dx.doi.org/10.1093/hmg/ddi134] [PMID: 15790595]
[http://dx.doi.org/10.1002/1531-8257(199911)14:6<1008::AID-MDS1015>3.0.CO;2-E] [PMID: 10584677]
[http://dx.doi.org/10.1001/archneur.60.8.1059] [PMID: 12925360]
[http://dx.doi.org/10.1073/pnas.0837397100] [PMID: 12702778]
[http://dx.doi.org/10.1523/JNEUROSCI.19-09-03440.1999] [PMID: 10212304]
[http://dx.doi.org/10.1073/pnas.0937239100] [PMID: 12721370]
[http://dx.doi.org/10.1016/0304-3940(94)90746-3] [PMID: 8015728]
[http://dx.doi.org/10.1016/0304-3940(94)90508-8] [PMID: 7700568]
[http://dx.doi.org/10.1016/0304-3940(95)11686-Q] [PMID: 7478158]
[http://dx.doi.org/10.1007/BF01291792] [PMID: 9013395]
[http://dx.doi.org/10.1016/0304-3940(96)12706-3] [PMID: 8809836]
[http://dx.doi.org/10.1038/cr.2009.131] [PMID: 19949427]
[http://dx.doi.org/10.1159/000323779] [PMID: 21430395]
[http://dx.doi.org/10.1038/ng.3955] [PMID: 28892059]
[http://dx.doi.org/10.1038/npjparkd.2015.2] [PMID: 27148593]
[http://dx.doi.org/10.1038/nature22815] [PMID: 28636593]
[http://dx.doi.org/10.1016/j.bbadis.2008.10.003] [PMID: 18992326]
[http://dx.doi.org/10.1002/mds.25157] [PMID: 22976926]
[http://dx.doi.org/10.1371/journal.pone.0057904] [PMID: 23469252]
[http://dx.doi.org/10.1001/archneur.62.2.281] [PMID: 15710857]
[http://dx.doi.org/10.1002/mds.25192] [PMID: 23115051]
[http://dx.doi.org/10.1007/BF02984560] [PMID: 15515743]
[http://dx.doi.org/10.1016/j.nbd.2005.08.002] [PMID: 16182554]
[http://dx.doi.org/10.1371/journal.pone.0055031] [PMID: 23405108]
[http://dx.doi.org/10.1080/15548627.2016.1147669] [PMID: 27050463]
[http://dx.doi.org/10.1002/mds.26802] [PMID: 27619775]
[http://dx.doi.org/10.1002/mds.26243] [PMID: 25900096]
[http://dx.doi.org/10.1093/brain/awx285] [PMID: 29140481]
[http://dx.doi.org/10.1371/journal.pone.0082879] [PMID: 24386122]
[http://dx.doi.org/10.1038/ng.3043] [PMID: 25064009]
[http://dx.doi.org/10.1016/j.tcb.2018.06.005] [PMID: 30072228]
[http://dx.doi.org/10.1242/jcs.103440] [PMID: 23148298]
[http://dx.doi.org/10.1038/s41580-019-0177-4] [PMID: 31705132]
[http://dx.doi.org/10.1016/j.tibs.2016.08.016] [PMID: 27669649]
[http://dx.doi.org/10.1002/mds.27119] [PMID: 28779532]
[http://dx.doi.org/10.1371/journal.pone.0160925] [PMID: 27508417]
[http://dx.doi.org/10.1212/WNL.0000000000002509] [PMID: 27044648]
[http://dx.doi.org/10.1016/S1474-4422(06)70521-X] [PMID: 16857573]
[http://dx.doi.org/10.3389/fneur.2014.00242] [PMID: 25566170]
[http://dx.doi.org/10.1002/mds.26078] [PMID: 25476691]
[http://dx.doi.org/10.1002/mds.26528] [PMID: 26817533]
[http://dx.doi.org/10.1007/s40265-014-0343-0] [PMID: 25559423]
[http://dx.doi.org/10.1016/S1474-4422(15)00336-1] [PMID: 26725544]
[http://dx.doi.org/10.1002/mds.23829] [PMID: 22021173]
[http://dx.doi.org/10.1001/jamaneurol.2016.4467] [PMID: 27942720]
[http://dx.doi.org/10.1001/jama.2014.3654] [PMID: 24756517]
[http://dx.doi.org/10.1097/WCO.0b013e3283542fc2] [PMID: 22691758]
[http://dx.doi.org/10.1136/jnnp.53.2.96] [PMID: 2313313]
[http://dx.doi.org/10.1002/mds.20276] [PMID: 15390035]
[http://dx.doi.org/10.1212/WNL.0b013e318285c0ed] [PMID: 23365054]
[http://dx.doi.org/10.1002/mds.25273] [PMID: 23225267]
[http://dx.doi.org/10.1007/s13311-013-0238-x] [PMID: 24288035]
[http://dx.doi.org/10.1016/S0140-6736(13)62106-6] [PMID: 24183563]
[http://dx.doi.org/10.1002/mds.23884] [PMID: 22021174]
[http://dx.doi.org/10.1517/14728214.2013.766168] [PMID: 23373820]
[http://dx.doi.org/10.1016/S1474-4422(13)70151-0] [PMID: 24050735]
[http://dx.doi.org/10.1126/scitranslmed.3003722]
[http://dx.doi.org/10.1002/mds.25344] [PMID: 23390096]
[http://dx.doi.org/10.1038/nm850] [PMID: 12669033]
[http://dx.doi.org/10.1002/ana.21032] [PMID: 17192932]
[http://dx.doi.org/10.1089/hum.2011.220] [PMID: 22424171]
[http://dx.doi.org/10.1016/S0140-6736(13)61939-X] [PMID: 24412048]
[http://dx.doi.org/10.1093/brain/awh374] [PMID: 15659429]
[http://dx.doi.org/10.1016/j.omtn.2017.06.011] [PMID: 28918020]
[http://dx.doi.org/10.1093/brain/awy126] [PMID: 29788236]
[http://dx.doi.org/10.1016/j.neuron.2016.09.021] [PMID: 27720486]
[PMID: 27867348]
[http://dx.doi.org/10.1093/brain/aww351] [PMID: 28100454]
[http://dx.doi.org/10.1038/mtm.2016.81] [PMID: 27933308]
[http://dx.doi.org/10.1371/journal.pone.0012122] [PMID: 20711464]
[http://dx.doi.org/10.3389/fncel.2017.00175] [PMID: 28713244]
[http://dx.doi.org/10.3389/fnins.2017.00476] [PMID: 28912673]
[http://dx.doi.org/10.3389/fnmol.2017.00409] [PMID: 29311802]
[http://dx.doi.org/10.3389/fnmol.2017.00164] [PMID: 28611589]
[http://dx.doi.org/10.2174/1871527317666180508123050] [PMID: 29745345]
[http://dx.doi.org/10.2174/1871527314666150225124928] [PMID: 25714978]
[http://dx.doi.org/10.2174/187152731131200119] [PMID: 24040822]
[http://dx.doi.org/10.2174/1871527313666140618110409] [PMID: 24040791]
[http://dx.doi.org/10.2174/1871527319666200417123948] [PMID: 32303175]
[http://dx.doi.org/10.2174/1871527315666161006104347] [PMID: 27719624]
[http://dx.doi.org/10.2174/1871527318666191114093749] [PMID: 31724519]
[http://dx.doi.org/10.1016/j.tins.2007.03.008] [PMID: 17408758]
[http://dx.doi.org/10.1016/S0166-2236(97)01096-5] [PMID: 9347617]
[http://dx.doi.org/10.1074/jbc.M306451200] [PMID: 12933819]
[http://dx.doi.org/10.1038/nn.2216] [PMID: 18953346]
[http://dx.doi.org/10.2174/157015909789152191] [PMID: 20190961]
[http://dx.doi.org/10.1016/B978-0-12-801022-8.00003-9] [PMID: 25175961]
[http://dx.doi.org/10.1016/j.brainres.2009.09.082] [PMID: 19785999]
[http://dx.doi.org/10.1016/j.nlm.2007.03.003] [PMID: 17467309]
[http://dx.doi.org/10.1038/npp.2015.227] [PMID: 26216520]
[http://dx.doi.org/10.1016/j.biopsych.2013.05.003] [PMID: 23820821]
[http://dx.doi.org/10.1016/j.neuropharm.2016.07.012] [PMID: 27424102]
[http://dx.doi.org/10.1002/mds.25418] [PMID: 23483627]
[http://dx.doi.org/10.1002/mds.22095] [PMID: 18831530]
[http://dx.doi.org/10.1080/14656566.2019.1614167] [PMID: 31039621]
[http://dx.doi.org/10.5603/PJNNS.a2019.0036] [PMID: 31441493]
[http://dx.doi.org/10.1016/j.nbd.2017.04.004] [PMID: 28400134]
[http://dx.doi.org/10.1002/ana.10113] [PMID: 11891824]
[http://dx.doi.org/10.1126/science.1096284] [PMID: 15087508]
[http://dx.doi.org/10.1016/j.gendis.2019.01.004] [PMID: 31193965]
[http://dx.doi.org/10.3390/jcm8091377] [PMID: 31484320]
[http://dx.doi.org/10.3233/JPD-161020] [PMID: 28222538]
[http://dx.doi.org/10.1073/pnas.1112368109] [PMID: 22647602]
[http://dx.doi.org/10.1038/ng1884] [PMID: 16964263]
[http://dx.doi.org/10.1177/1073858417748875] [PMID: 29400127]
[http://dx.doi.org/10.1002/path.5312] [PMID: 31144295]
[http://dx.doi.org/10.3389/fneur.2019.00915] [PMID: 31496990]
[http://dx.doi.org/10.18632/aging.102695] [PMID: 31932518]