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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Ryanodine Receptor as Insecticide Target

Author(s): Arthur Samurkas, Li Yao, Hadiatullah Hadiatullah, Ruifang Ma, Yunxuan Xie, Rajamanikandan Sundarraj, Han Zuilhof and Zhiguang Yuchi*

Volume 28, Issue 1, 2022

Published on: 02 September, 2021

Page: [26 - 35] Pages: 10

DOI: 10.2174/1381612827666210902150224

Price: $65


The ryanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide insecticide family, including flubendiamide, chlorantraniliprole, cyantraniliprole, etc., targets insect RyRs and can be used to control a wide range of destructive agricultural pests. The diamide insecticides are highly selective against lepidopteran and coleopteran pests with relatively low toxicity for non-target species, such as mammals, fishes, and beneficial insects. However, recently mutations identified on insect RyRs have emerged and caused resistance in several major agricultural pests throughout different continents. This review paper summarizes the recent findings on the structure and function of insect RyRs as insecticide targets. Specifically, we examine the structures of RyRs from target and non-target species, which reveals the molecular basis for insecticide action and selectivity. We also examine the structural and functional changes of RyR caused by the resistance mutations. Finally, we examine the progress in RyR structure-based insecticide design and discuss how this might help the development of a new generation of green insecticides.

Keywords: Ryanodine receptor, insecticide, resistance, target, diamide, structural biology.

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