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Current Pharmaceutical Analysis


ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

In Vitro Antioxidant Capacity vs In Vivo Antimetastatic Effect of Anticancer Cobalt Complexes

Author(s): Luigi Campanella, Gabriele Favero, Sergey P. Osinsky, Andrej L. Sigan and Mauro Tomassetti

Volume 4, Issue 2, 2008

Page: [44 - 52] Pages: 9

DOI: 10.2174/157341208784246279

Price: $65


Four different methods were used to measure the “in vitro” antioxidant capacity of three cobalt complexes recently proposed as anticancer active principles: a new biosensor method and a new pulse voltammetric, or pulse polarographic method, together with two other methods - one fluorimetric and the other spectrophotometric. Results obtained using the different methods are discussed and compared with the anti-metastatic effect recently measured “in vivo” by Russian authors. The good correlation found between anti-tumoral and anti-metastatic activity ranking and in vitro antioxidant activity found by the new voltammetric method suggests interesting hypotheses based on the anti-tumoral effect of these complexes.

Keywords: superoxide dismutase, ORAC Spectrofluorimetric Method, Differential Pulse Voltammetry, pH value, antioxidant

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