Abstract
Abstract: Age-related hearing loss (ARHL) or presbycusis shares common features with conditions related to senescence and neurodegeneration. In this review, we explore the linking of genes involved in such processes with presbycusis, that has been proven to share important relationships with genes involved in dementia (APOE and MTHFR), ototoxicity (the GST group), and pharmacogenetics (NAT2). In this regard, we propose the construction of pharmacogenetics for the presbycusis database that could help better control side effects in this particularly vulnerable population susceptible to neurodegenerative disorders. Moreover, preliminary epigenetics studies have recently identified links in human genes involved in ARHL, which could serve as biomarkers or as therapeutic targets.
Keywords: Presbycusis, genomics, pharmacogenomics, age-related hearing loss, APOE, NAT2, MTHFR.
Current Pharmacogenomics and Personalized Medicine
Title:Genomics and Pharmacogenomics of Age-related Hearing Loss
Volume: 18 Issue: 2
Author(s): Joaquin Guerra*, Vinogran Naidoo and Ramon Cacabelos
Affiliation:
- EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, Bergondo 15165 Corunna, Spain
Keywords: Presbycusis, genomics, pharmacogenomics, age-related hearing loss, APOE, NAT2, MTHFR.
Abstract: Abstract: Age-related hearing loss (ARHL) or presbycusis shares common features with conditions related to senescence and neurodegeneration. In this review, we explore the linking of genes involved in such processes with presbycusis, that has been proven to share important relationships with genes involved in dementia (APOE and MTHFR), ototoxicity (the GST group), and pharmacogenetics (NAT2). In this regard, we propose the construction of pharmacogenetics for the presbycusis database that could help better control side effects in this particularly vulnerable population susceptible to neurodegenerative disorders. Moreover, preliminary epigenetics studies have recently identified links in human genes involved in ARHL, which could serve as biomarkers or as therapeutic targets.
Export Options
About this article
Cite this article as:
Guerra Joaquin*, Naidoo Vinogran and Cacabelos Ramon, Genomics and Pharmacogenomics of Age-related Hearing Loss, Current Pharmacogenomics and Personalized Medicine 2021; 18 (2) . https://dx.doi.org/10.2174/1875692118666210823115347
DOI https://dx.doi.org/10.2174/1875692118666210823115347 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Molecular Mechanisms Involved in the Aging of the T-cell Immune Response
Current Genomics Withdrawal Notice: Design and optimization of piezoresistive based microbridge electro-osmosis pressure sensor
Micro and Nanosystems Aquaporin-1 and Sodium-Hydrogen Exchangers as Pharmacological Targets in Diabetic Atherosclerosis
Current Drug Targets Interactive Effect of Cigarette Smoking and Gene Variants for Predisposing to Cardiovascular Disease
Current Pharmaceutical Design Interactions of Dietary Fibre with Nutritional Components on Gut Microbial Composition, Function and Health in Monogastrics
Current Protein & Peptide Science HDL and Inflammation in Atherosclerosis
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The Cytoprotective and Anti-cancer Potential of Bisbenzylisoquinoline Alkaloids from <I>Nelumbo nucifera</I>
Current Topics in Medicinal Chemistry Delivery of Nanoparticles for Treatment of Brain Tumor
Current Drug Metabolism Estrogens, a Female Hormone Concerned in Spermatogenesis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Efficacy and Cardiovascular Safety of Metformin
Current Drug Safety Transition Metal-mediated Uncaging Chemistry in Prodrug Design
Current Topics in Medicinal Chemistry Oxidative Stress and Cancer: The Role of Nrf2
Current Cancer Drug Targets Metabolic Targeting of Cancers: From Molecular Mechanisms to Therapeutic Strategies
Current Medicinal Chemistry Physiological Basis for Contractile Dysfunction in Heart Failure
Current Pharmaceutical Design Role of ARBs in the Blood Hypertension Therapy and Prevention of Cardiovascular Events
Current Drug Targets Broadening Our View of Protective Antibody Responses Against HIV
Current HIV Research Lifestyle, Maternal Nutrition and Healthy Pregnancy
Current Vascular Pharmacology PAI-1 Antagonists: Predictable Indications and Unconventional Applications
Current Drug Targets Diabetic Bone Fracture Repair: A Progenitor Cell-Based Paradigm
Current Stem Cell Research & Therapy The Interaction between KCNJ11 Gene Polymorphism and Refined Carbohydrates Intake on Obesity in Indonesian Adolescents
Current Nutrition & Food Science