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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

阿尔茨海默病的危险因素：一项流行病学研究

卷 18, 期 5, 2021

发表于: 20 August, 2021

页: [372 - 379] 页: 8

弟呕挨: 10.2174/1567205018666210820124135

价格: $65

摘要

简介：痴呆症已成为捷克共和国和全世界的主要公共卫生挑战。最常见的痴呆症是阿尔茨海默病 (AD)。 目标：我们在 2012-2015 年和 2016-2019 年连续开展了两个流行病学项目。他们的目的是通过比较 AD 患者和对照组中选定的潜在遗传、血管和社会心理风险因素对 AD 发展的影响。 方法：进行流行病学病例对照研究。总共分析了 2106 名参与者（1096 名病例，1010 名对照）的数据。 结果：患有AD的女性是男性的三倍。与对照组不同，病例比例最高的是那些接受过小学教育的病例。与对照组相比，病例中的体力劳动者在统计学上显着更多。在选定的血管危险因素中，发现冠心病在病例中的发生率显着高于对照组。高血压和糖尿病的发病在对照组中比在病例中早。至于爱好和兴趣，两组之间在体育活动、阅读和解决填字游戏方面存在统计学上的显着差异，这些活动在对照组中更为常见。 结论：慢性神经退行性疾病，特别是 AD 的患病率目前正在增加。鉴于人口老龄化，这些疾病的流行率可能会上升。需要研究、分析和确认 AD 的潜在风险；因此，详细了解 AD 的风险和早期发现病理可能非常有利于预防和早期治疗这种情况。

关键词: 痴呆症、阿尔茨海默病、流行病学、风险因素、神经退行性疾病。

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