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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

General Review Article

Research Progress on Natural Compounds Exerting an Antidepressant Effect through Anti-inflammatory

Author(s): Caixia Yuan, Yucen Yao, Tao Liu, Ying Jin*, Chunrong Yang*, Xian Jun Loh and Zibiao Li*

Volume 29, Issue 5, 2022

Published on: 05 January, 2022

Page: [934 - 956] Pages: 23

DOI: 10.2174/0929867328666210820115259

Price: $65


Depression is a common mental illness that belongs to the category of emotional disorders that causes serious damage to the health and life of patients, while inflammation is considered to be one of the important factors that cause depression. In this case, it might be important to explore the possible therapeutic approach by using natural compounds exerting an anti-inflammatory and antidepressant effect, which has not been systematically reviewed recently. Hence, this review aims to systematically sort the literature related to the mechanism of exerting an antidepressant effect through antiinflammatory actions and to summarize the related natural products in the past 20 years in terms of several inflammatory-related pathways (i.e., the protein kinase B (Akt) pathway, monoamine neurotransmitters (5-hydroxytryptamine and norepinephrine) (5-HT and NE), the nod-like receptor protein-3 (NLRP3) inflammasome, proinflammatory cytokines, neurotrophins, or cytokine-signaling pathways), which might provide a useful reference for the potential treatment of depression.

Keywords: Depression, anti-inflammatory, NLRP3 inflammasome, proinflammatory cytokine, natural compounds, antidepressant.

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