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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Direct Modulation of the Gut Microbiota as a Therapeutic Approach for Alzheimer’s Disease

Author(s): Yi Wang* and Gary A. Dykes

Volume 21, Issue 1, 2022

Published on: 06 August, 2021

Page: [14 - 25] Pages: 12

DOI: 10.2174/1871527320666210806165751

Price: $65

Abstract

Alzheimer’s disease is a neurodegenerative disease characterized by a progressive decline in memory and cognitive functions. It is a multifactorial disease involving a wide range of pathological factors that are not fully understood. As supported by a growing amount of evidence in recent years, gut microbiota plays an important role in the pathogenesis of Alzheimer’s disease through the brain-gut-microbiota axis. This suggests that direct modulation of the gut microbiota can be a potential therapeutic target for Alzheimer’s disease. This review summarizes recent research findings on the modulation of the gut microbiota by probiotic therapies and faecal microbiota transplantation for controlling the pathologies of Alzheimer’s disease. Current limitations and future research directions of this field are also discussed.

Keywords: Alzheimer’s disease, gut microbiota, probiotics, faecal microbiota transplantation, beta-amyloid, central nervous system.

Graphical Abstract
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