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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Metal Complexation Mechanisms of Polyphenols Associated to Alzheimer’s Disease

Author(s): Arian Kola*, Dorota Dudek and Daniela Valensin*

Volume 28 , Issue 35 , 2021

Published on: 29 July, 2021

Page: [7278 - 7294] Pages: 17

DOI: 10.2174/0929867328666210729120242

Price: $65

Abstract

Polyphenols are a class of compounds, produced by plants, which share the ability to act as potent antioxidants. First investigations on polyphenols’ antioxidant activity are dated almost twenty years ago when their relationship and implication with the prevention and treatment of cancer was proposed for the first time. Later, in the early 2000s, the neuroprotective effects of several polyphenols were demonstrated. Nowadays, the benefits of a plethora of polyphenols have been studied and their ameliorating effects in several disease conditions, like cancer, cardiac and neuronal diseases are widely recognised. More than 1000 papers dealing with polyphenols and Alzheimer’s disease have been published so far, describing the antioxidant properties, the metal chelating features and the anti-aggregating behavior of these compounds. The aim of this review is to rationalize, from a chemical point of view, the metal complexation mechanisms of polyphenols related to two significant events of Alzheimer’s disease: oxidative stress and metal ion dyshomeostasis. In order to address this issue, we have herein discussed several aspects implicated in Alzheimer’s disease and polyphenols involved in the treatment of the disease.

Keywords: Polyphenols, copper ions, Alzheimer's disease, antioxidant activity, aggregation, amyloid.


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