Generic placeholder image

Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article (Mini-Review)

Bis-triazole-containing Compounds with Anticancer Potential: A Short Review

Author(s): Meixiang Gao, Qiang Diao, Feng Gao, Xiangyang Sun* and Jiaqi Xiao*

Volume 21 , Issue 18 , 2021

Published on: 28 July, 2021

Page: [1674 - 1691] Pages: 18

DOI: 10.2174/1568026621666210728154728

Price: $65


The development of novel anticancer agents with high efficiency is of great importance due to the severe anticancer scenario of the currently used drugs. Dimerization is a useful method to develop new drug candidates with a broad biological spectrum, enhanced activity and potency to overcome drug resistance. A wide variety of bis-triazole-containing compounds have been developed with improved properties compared with their parent compounds. These derivatives could inhibit tumor proliferation, invasion and metastasis, revealing their potential as putative anticancer candidates. This review covers the recent advances of bis-triazole-containing compounds as anticancer candidates, and the structure-activity relationship are also discussed to set up the direction for the design and development of bis-triazole-containing compounds with higher efficiency.

Keywords: 1, 2, 3-triazole, 1, 2, 4-triazole, Dimers, Hybrids, Anticancer, Structure-activity relationship, Dimerization.

Graphical Abstract

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy