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Current Psychopharmacology


ISSN (Print): 2211-5560
ISSN (Online): 2211-5579

Review Article

Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review

Author(s): Anil K. Pradhan, Bimala Tripathy*, Bimalendu Chowdhury, Sasmita K. Acharjya and Rajaram Das

Volume 10, Issue 3, 2021

Published on: 28 July, 2021

Page: [218 - 228] Pages: 11

DOI: 10.2174/2211556010666210728123937

Price: $65


Background: The exact pathogenesis of Alzheimer’s disease is still a matter to debate. Currently there is no reliable therapy established for Alzheimer’s disease. However, several pieces of evidence suggest that the use of plant based phytoconstituents mainly delays the onset of Alzheimer’s disease. So, in this review, we collect information about the cause of Alzheimer’s disease hypothesis and the neuroprotective effect of phytoconstituents.

Objective: This review paper aimed to analyze the current pathogenesis of Alzheimer’s disease and therapeutic effect of plant phytoconstituents that play a vital role in neuroprotective and antistress activities in Alzheimer’s disease and other neurodegenerative disorders.

Methods: The source of literature review obtained from Scopus, Science Direct, PubMed, Web of Science database, and journal by using Alzheimer’s pathogenesis, neuroinflammation, oxidative stress, amyloid beta, flavonoids, alkaloids are an important part of these review research.

Results: The current review explored different types of pathogenesis involved in Alzheimer’s disease and the role of phytoconstituents in its treatment. The collected information showed that plant based constituents inhibit the major cause of Alzheimer’s disease related to amyloid beta, tau protein, oxidative stress, neuroinflammation, etc.

Conclusion: The study provides the clue for the investigation of eminent bioactive constituents may serve as an alternative candidate against Alzheimer’s disease and other neurodegenerative disorders.

Keywords: Amyloid beta, amyloid precursor protein, tau hyperphosphorylation, oxidative stress, neuroprotection, phytochemicals.

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