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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Dibenzofurans from Lichens – A Pharmacological Overview

Author(s): Isabel Ureña-Vacas, Elena González Burgos, Pradeep Kumar Divakar and Maria Pilar Gómez-Serranillos*

Volume 21 , Issue 26 , 2021

Published on: 27 July, 2021

Page: [2397 - 2408] Pages: 12

DOI: 10.2174/1568026621666210728095214

Price: $65


Lichens are a symbiotic association between a fungus (mycobiont) and a green algae/- cyanobacterium (photobiont). Lichens are a source of secondary metabolites, most of them being exclusively for these species, among which dibenzofurans are found. Dibenzofurans are a small group (over 35 different identified compounds), being usnic acid the most studied. In the last 10 years, there has been a growing interest in the pharmacological activity of dibenzofurans. In this work, dibenzofurans isolated from lichens (alectosarmentin, condidymic acid, didymic acid, isousnic acid, isostrepsilic acid, usimines A-C and usnic acid) were reviewed, most of which showed antibacterial, antifungal, and cytotoxic activities. These findings provide future guidance for research on pharmacological activity of dibenzofurans.

Keywords: Dibenzofurans, Lichens, Pharmacology, Activities, Secondary metabolites, Orsellinic acid.

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