Abstract
Lichens are a symbiotic association between a fungus (mycobiont) and a green algae/- cyanobacterium (photobiont). Lichens are a source of secondary metabolites, most of them being exclusively for these species, among which dibenzofurans are found. Dibenzofurans are a small group (over 35 different identified compounds), being usnic acid the most studied. In the last 10 years, there has been a growing interest in the pharmacological activity of dibenzofurans. In this work, dibenzofurans isolated from lichens (alectosarmentin, condidymic acid, didymic acid, isousnic acid, isostrepsilic acid, usimines A-C and usnic acid) were reviewed, most of which showed antibacterial, antifungal, and cytotoxic activities. These findings provide future guidance for research on pharmacological activity of dibenzofurans.
Keywords: Dibenzofurans, Lichens, Pharmacology, Activities, Secondary metabolites, Orsellinic acid.
Current Topics in Medicinal Chemistry
Title:Dibenzofurans from Lichens – A Pharmacological Overview
Volume: 21 Issue: 26
Author(s): Isabel Ureña-Vacas, Elena González Burgos, Pradeep Kumar Divakar and Maria Pilar Gómez-Serranillos*
Affiliation:
- Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, University Complutense of Madrid, Madrid,Spain
Keywords: Dibenzofurans, Lichens, Pharmacology, Activities, Secondary metabolites, Orsellinic acid.
Abstract: Lichens are a symbiotic association between a fungus (mycobiont) and a green algae/- cyanobacterium (photobiont). Lichens are a source of secondary metabolites, most of them being exclusively for these species, among which dibenzofurans are found. Dibenzofurans are a small group (over 35 different identified compounds), being usnic acid the most studied. In the last 10 years, there has been a growing interest in the pharmacological activity of dibenzofurans. In this work, dibenzofurans isolated from lichens (alectosarmentin, condidymic acid, didymic acid, isousnic acid, isostrepsilic acid, usimines A-C and usnic acid) were reviewed, most of which showed antibacterial, antifungal, and cytotoxic activities. These findings provide future guidance for research on pharmacological activity of dibenzofurans.
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Cite this article as:
Ureña-Vacas Isabel, Burgos González Elena , Divakar Kumar Pradeep and Gómez-Serranillos Pilar Maria *, Dibenzofurans from Lichens – A Pharmacological Overview, Current Topics in Medicinal Chemistry 2021; 21 (26) . https://dx.doi.org/10.2174/1568026621666210728095214
DOI https://dx.doi.org/10.2174/1568026621666210728095214 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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