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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Discovery and Development of Macrolides as Anticancer Agents

Author(s): Rongli Liu, Yani Hou and Yijun Gu*

Volume 21 , Issue 18 , 2021

Published on: 27 July, 2021

Page: [1657 - 1673] Pages: 17

DOI: 10.2174/1568026621666210727163420

Price: $65


Cancer is a life-threatening destructive disease. In the past several decades, the incidence of cancer has been dramatically increased mostly due to lifestyle changes. Chemotherapy plays an important role in the treatment of cancer, but the development of resistance against chemotherapeutic agents, the side effects, and non-specific toxicity threatens the efficiency of anticancer agents. Accordingly, it is important to develop novel anticancer drugs. Beyond the classical antibacterial activity, macrolides also demonstrated potential effects against both drug-sensitive and drug-resistant cancers through modulating diverse targets and signaling pathways, so rational design of macrolides may generate valuable therapeutic interventions for the treatment of cancers. The purpose of the present review article is to outline the current developments in macrolides with an emphasis on anticancer activity, structure-activity relationships, and mechanisms of action to lay the path for the development of novel macrolide anticancer candidates.

Keywords: Macrolides, Anticancer, Structure-activity relationship, Mechanisms of action, Chemotherapy, Radiation therapy.

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