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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Recent Advancements in the Synthesis and Chemistry of Benzo-fused Nitrogen- and Oxygen-based Bioactive Heterocycles

Author(s): Ritu Sharma, Ravi K. Yadav, Richa Sharma, Nawal K. Sahu, Mukesh Jain and Sandeep Chaudhary*

Volume 21 , Issue 17 , 2021

Published on: 15 July, 2021

Page: [1538 - 1571] Pages: 34

DOI: 10.2174/1568026621666210715122919

Price: $65

Abstract

Since a variety of benzo-fused nitrogen- and oxygen-based bioactive heterocyclic moieties are present in the form of benzoxazinones, spirooxindole-based heterocyclic compounds, coumarinfused heterocyclic compounds, and 2H-indazoles, this review article briefly describes some of the major advancements and developments in the area of 1,4-benzoxazine-3-ones, 1,4-benzoxazin-2- ones, spiropyrrolidine and spiropyrrolizine-based ring compounds, coumarin-fused compounds, benzopyran- fused coumarins and a 2H-indazoles class of bioheterocycles. Thus, keeping in view the medicinal importance of these bioactive benzo-fused heterocycles, special attention has been given to their synthesis as well as medicinal/pharmaceutical properties in detail.

Keywords: Benzo-fused, Heterocycles, Bioactive, Benzoxazinones, Spirooxindole, Coumarin, Benzopyran, 2H-indazole.

Graphical Abstract

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