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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Predicting 3D Structures of Protein-Protein Complexes

Author(s): Ilya A. Vakser and Petras Kundrotas

Volume 9, Issue 2, 2008

Page: [57 - 66] Pages: 10

DOI: 10.2174/138920108783955209

Price: $65

Abstract

The protein-protein docking problem is one of the focal points of activity in computational structural biology. Adequate computational techniques for structural modeling of protein interactions are important because of the growing number of known protein structures, particularly in the context of structural genomics. The protein docking methodology offers tools for fundamental studies of protein interactions and provides structural basis for drug design. The paper presents a critical review of the existing protein-protein docking approaches in view of the fundamental principles of protein recognition.

Keywords: Protein recognition, structural bioinformatics, protein modeling, docking


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