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Current Molecular Medicine

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ISSN (Online): 1875-5666

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General Review Article

The Regulatory Role of Pivotal MicroRNAs in the AKT Signaling Pathway in Breast Cancer

Author(s): Sina Taefehshokr, Nima Taefehshokr, Afshin Derakhshani, Amir Baghbanzadeh , Reza Vaezi Astamal, Sahar Safaei, Samane Abbasi, Saba Hajazimian, Nazila Fathi Maroufi, Alireza Isazadeh, Khalil Hajiasgharzadeh and Behzad Baradaran*

Volume 22, Issue 3, 2022

Published on: 09 August, 2021

Page: [263 - 273] Pages: 11

DOI: 10.2174/1566524021666210708095051

Price: $65

Abstract

Breast cancer is the most prevalent type of cancer among women, and it remains the main challenge despite improved treatments. MicroRNAs (miRNAs) are a small non-coding family of RNAs that play an indispensable role in regulating major physiological processes, including differentiation, proliferation, invasion, migration, cell cycle regulation, stem cell maintenance apoptosis, and organ development. The dysregulation of these tiny molecules is associated with various human malignancies. More than 50% of these non-coding RNA sequences estimated have been placed on genomic regions or fragile sites linked to cancer. Following the discovery of the first signatures of specific miRNA in breast cancer, numerous researches focused on involving these tiny RNAs in breast cancer physiopathology as a new therapeutic approach or as reliable prognostic biomarkers. In the current review, we focus on recent findings related to the involvement of miRNAs in breast cancer via the AKT signaling pathway related to their clinical implications.

Keywords: Breast cancer, MicroRNA, AKT signaling pathway, PTEN, RNAs, dysregulation.

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