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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

General Review Article

Synthetic and Biological Attributes of Pyrimidine Derivatives: A Recent Update

Author(s): Meenu Devi*, Shivangi Jaiswal, Sonika Jain, Navjeet Kaur and Jaya Dwivedi

Volume 18, Issue 8, 2021

Published on: 06 July, 2021

Page: [790 - 825] Pages: 36

DOI: 10.2174/1570179418666210706152515

Price: $65

Abstract

Nitrogen-containing heterocycles attract the attention of chemists due to their multifarious activities. Amongst all, pyrimidine plays a central role and exhibits a broad spectrum of biological activities. Literature is replete with various aspects of synthetic development in the chemistry of pyrimidine for a wide array of applications. It aroused our interest to compile various novel and efficient synthetic approaches towards the synthesis of pyrimidine and its derivatives. Pyrimidine derivatives are broadly useful as therapeutic agents, owing to their high degree of structural diversity. They have been recorded to possess a diverse range of therapeutic activities viz. anticancer, anti-inflammatory, anti-HIV etc.

Keywords: Heterocycles, pyrimidine, synthesis, coupling reactions, green methods, anticancer .

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