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Current Cancer Therapy Reviews


ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

Mini-Review Article

Molecular Landscape of Lung Epithelium Contributes to High Severity and Comorbidities for COVID-19 and Lung Cancer

Author(s): Nilesh Kumar Sharma*, Sachin C Sarode, Gargi S Sarode and Shankargouda Patil

Volume 18, Issue 1, 2022

Published on: 05 July, 2021

Page: [2 - 6] Pages: 5

DOI: 10.2174/1573394717666210705115359

Price: $65


The heterogeneous and complex nature of cancer is extensively revealed at molecular, genetic, and tissue microenvironment levels. Currently, co-occurrence of coronavirus disease 2019 (COVID-19) to lung cancer patients and severity of infections by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been understood at preclinical and clinical levels. However, molecular and cellular insights are not discussed in those papers that support the increased COVID-19 severity and comorbidities in several cancer types, including lung cancer patients. Therefore, this perspective highlights the basis of high severity and comorbidities among lung cancer patients infected by COVID-19 with an emphasis on translational aspects.

Keywords: Neoplasia, lung epithelial tissue, cellular signaling, COVID-19, lung, cancer, SARS-Cov-2.

Graphical Abstract
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