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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

SARS-Cov-2 Damage on the Nervous System and Mental Health

Author(s): Mohamed Said Boulkrane, Victoria Ilina, Roman Melchakov, Mikhail Arisov, Julia Fedotova*, Lucia Gozzo, Filippo Drago , Weihong Lu, Alexey Sarapultsev, Vadim Tseilikman and Denis Baranenko

Volume 20, Issue 2, 2022

Published on: 07 February, 2022

Page: [412 - 431] Pages: 20

DOI: 10.2174/1570159X19666210629151303

Price: $65


The World Health Organization declared the pandemic situation caused by SARSCoV- 2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mildmoderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.

Keywords: SARS-CoV-2, COVID-19, mental health, neurological diseases, brain disorders, neuroinvasive potential.

Graphical Abstract
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