Most of the traditional methods for organic synthesis have been associated with environmental concern. The transition from traditional to modern methods of synthesis is mainly based on principles of green chemistry to achieve better sustainability by reducing the negative impact on the environment and health. It has been found that the use of microwaves as an energy source in organic synthesis has a great advantage over conventional heating. Microwave-assisted reactions are energy efficient and hence, are being considered in the preview of the green chemistry principles. The use of safer solvents is another important principle of green chemistry. The use of water as a solvent in organic synthesis has great benefits over the use of hazardous organic solvents in terms of environment and safety. This compilation will cover the use of both microwave and water simultaneously in organic reactions.