Abstract
Breast milk (BrM) is not only a nutrition supply but also contains a diverse population of cells. It has been estimated that up to 6% of the cells in human milk possess the characteristics of mesenchymal stem cells (MSC). Available data also indicate that these cells are multipotent and capable of self-renewal and differentiation to other cells. In this review, we have compared different characteristics such as CD markers, differentiation capacity, and morphology of stem cells derived from human breast milk (hBr-MSC) with human bone marrow (hBMSC), Wharton's jelly (WJMSC), and human adipose tissue (hADMSC). The literature review revealed that human breast milk-derived stem cells specifically express a group of cell surface markers, including CD14, CD31, CD45, and CD86. Importantly, a group of markers, CD13, CD29, CD44, CD105, CD106, CD146, and CD166, were identified which were common in the four sources of stem cells. WJMSC, hBMSC, hADMSC, and hBr-MSC are potently able to differentiate into the mesoderm, ectoderm, and endoderm cell lineages. The ability of hBr-MSCs in differentiation into the neural stem cells, neurons, adipocyte, hepatocyte, chondrocyte, osteocyte, and cardiomyocytes has made these cells a promising source of stem cells in regenerative medicine, while isolation of stem cells from the commonly used sources, such as bone marrow, requires invasive procedures. Although autologous breast milk-derived stem cells are an accessible source for women who are in the lactation period, breast milk can be considered a source of stem cells with high differentiation potential without any ethical concern.
Keywords: Mesenchymal stem cell, breast milk, bone marrow, Wharton's jelly, adipose tissue, differentiation.
[http://dx.doi.org/10.1186/s11658-017-0042-4] [PMID: 28717367]
[http://dx.doi.org/10.1371/journal.pone.0078232] [PMID: 24223141]
[http://dx.doi.org/10.1038/s41598-018-32715-5] [PMID: 30250150]
[http://dx.doi.org/10.1007/s00441-007-0390-x] [PMID: 17440749]
[http://dx.doi.org/10.4161/cc.10.2.14470] [PMID: 21239874]
[http://dx.doi.org/10.1002/stem.1092] [PMID: 22593019]
[http://dx.doi.org/10.1111/j.1749-0774.2010.00083.x] [PMID: 20712706]
[http://dx.doi.org/10.1002/stem.624] [PMID: 21374761]
[http://dx.doi.org/10.1002/stem.1188] [PMID: 22865647]
[http://dx.doi.org/10.1007/s13770-017-0066-x] [PMID: 30603512]
[http://dx.doi.org/10.1155/2014/807896] [PMID: 25506428]
[http://dx.doi.org/10.1002/cbin.10432] [PMID: 25572907]
[http://dx.doi.org/10.1007/s10616-012-9492-8] [PMID: 22940915]
[http://dx.doi.org/10.21037/pm.2019.02.02]
[http://dx.doi.org/10.1089/bfm.2015.0124] [PMID: 26670023]
[http://dx.doi.org/10.1007/s10142-016-0485-0] [PMID: 26909879]
[http://dx.doi.org/10.1371/journal.pone.0014421] [PMID: 21203434]
[http://dx.doi.org/10.1089/bfm.2017.0002] [PMID: 28277748]
[http://dx.doi.org/10.1177/0890334413477242] [PMID: 23515088]
[http://dx.doi.org/10.1089/bfm.2016.0021] [PMID: 26959399]
[http://dx.doi.org/10.1002/ca.22165] [PMID: 22997014]
[http://dx.doi.org/10.1073/pnas.1218682110] [PMID: 23487770]
[http://dx.doi.org/10.1038/s41598-017-03681-1] [PMID: 28615711]
[PMID: 30692826]
[http://dx.doi.org/10.1016/S0165-2478(03)00108-1] [PMID: 14556988]
[http://dx.doi.org/10.1007/s00418-005-0014-z] [PMID: 16032396]
[http://dx.doi.org/10.1634/stemcells.2004-0021] [PMID: 15749936]
[http://dx.doi.org/10.1007/s12015-012-9365-8] [PMID: 22529014]
[http://dx.doi.org/10.1016/j.bbmt.2007.08.048] [PMID: 18022578]
[http://dx.doi.org/10.1634/stemcells.20-3-249] [PMID: 12004083]
[PMID: 21566786]
[http://dx.doi.org/10.1007/s00441-008-0696-3] [PMID: 18941782]
[http://dx.doi.org/10.1111/j.1432-0436.2006.00139.x] [PMID: 17288545]
[http://dx.doi.org/10.6061/clinics/2012(02)03] [PMID: 22358233]
[http://dx.doi.org/10.1002/jcp.1138] [PMID: 11573204]
[http://dx.doi.org/10.1002/bab.38] [PMID: 21838801]
[PMID: 24398986]
[http://dx.doi.org/10.1634/stemcells.2005-0330] [PMID: 16223852]
[http://dx.doi.org/10.1634/stemcells.2007-0439] [PMID: 18065397]
[http://dx.doi.org/10.1634/stemcells.2006-0308erratum] [PMID: 17053209]
[http://dx.doi.org/10.1007/s00418-008-0519-3] [PMID: 18836737]
[http://dx.doi.org/10.1016/j.nbd.2007.06.010] [PMID: 17651977]
[http://dx.doi.org/10.1016/j.placenta.2010.11.003] [PMID: 21126763]
[http://dx.doi.org/10.1007/s12015-010-9166-x] [PMID: 20602182]
[http://dx.doi.org/10.1634/stemcells.2006-0228] [PMID: 16873762]
[http://dx.doi.org/10.1016/j.exphem.2005.07.003] [PMID: 16263424]
[http://dx.doi.org/10.1182/blood.V98.9.2615] [PMID: 11675329]
[http://dx.doi.org/10.1080/14653240310004539] [PMID: 14985162]
[http://dx.doi.org/10.1016/j.stemcr.2014.01.002] [PMID: 24527391]
[http://dx.doi.org/10.1089/ten.tea.2015.0039] [PMID: 26020286]
[http://dx.doi.org/10.1007/s12185-009-0377-3] [PMID: 19657615]
[http://dx.doi.org/10.1155/2017/3175748] [PMID: 28874910]
[http://dx.doi.org/10.4252/wjsc.v6.i2.195] [PMID: 24772246]
[http://dx.doi.org/10.1089/scd.2011.0186] [PMID: 21732813]
[http://dx.doi.org/10.1089/scd.2009.0485] [PMID: 20367285]
[PMID: 21072260]
[http://dx.doi.org/10.1002/jcb.21078] [PMID: 16960877]
[http://dx.doi.org/10.1007/s12015-010-9184-8] [PMID: 20711690]
[http://dx.doi.org/10.1053/j.gastro.2007.12.024] [PMID: 18243183]
[http://dx.doi.org/10.1002/jcb.24057] [PMID: 22234854]
[http://dx.doi.org/10.1007/s00441-011-1306-3] [PMID: 22287041]
[http://dx.doi.org/10.1007/s10616-014-9841-x] [PMID: 25777046]
[http://dx.doi.org/10.1111/j.1365-2141.2005.05409.x] [PMID: 15801964]
[http://dx.doi.org/10.1046/j.1365-2141.2003.04284.x] [PMID: 12694261]
[http://dx.doi.org/10.1182/blood.V99.10.3838] [PMID: 11986244]
[http://dx.doi.org/10.1158/0008-5472.CAN-06-4690] [PMID: 17909019]
[http://dx.doi.org/10.1053/bbmt.2001.v7.pm11760145] [PMID: 11760145]
[http://dx.doi.org/10.1016/j.gmbhs.2011.08.003]
[http://dx.doi.org/10.1091/mbc.e02-02-0105] [PMID: 12475952]
[http://dx.doi.org/10.1002/cbf.1488] [PMID: 18636461]
[http://dx.doi.org/10.1089/scd.2012.0346] [PMID: 22920587]
[http://dx.doi.org/10.1016/j.cryobiol.2008.04.002] [PMID: 18495102]
[http://dx.doi.org/10.1155/2016/3516574] [PMID: 26880954]
[http://dx.doi.org/10.1038/s41598-018-34527-z] [PMID: 30389962]
[http://dx.doi.org/10.1007/s00441-017-2699-4] [PMID: 29204746]
[http://dx.doi.org/10.4103/0973-6247.59386] [PMID: 20376261]
[http://dx.doi.org/10.1634/stemcells.2006-0286] [PMID: 17053211]
[http://dx.doi.org/10.1089/ten.tec.2011.0508] [PMID: 22166141]
[http://dx.doi.org/10.1111/j.1582-4934.2011.01352.x] [PMID: 21645238]
[http://dx.doi.org/10.1634/stemcells.2008-0456] [PMID: 18832592]
[http://dx.doi.org/10.1080/21645515.2015.1030549] [PMID: 26186552]
[http://dx.doi.org/10.1016/j.jcyt.2016.08.003] [PMID: 27727016]
[http://dx.doi.org/10.1111/j.1423-0410.2008.01076.x] [PMID: 18557828]
[http://dx.doi.org/10.3892/ijmm.2015.2413] [PMID: 26719857]
[http://dx.doi.org/10.3390/ijms140917986] [PMID: 24005862]
[http://dx.doi.org/10.1177/0963689718759913] [PMID: 29860900]
[http://dx.doi.org/10.1186/s13287-017-0555-9] [PMID: 28446235]
[http://dx.doi.org/10.1155/2015/575837] [PMID: 26064925]
[http://dx.doi.org/10.1155/2014/832736] [PMID: 24818157]
[http://dx.doi.org/10.3727/096368912X647162] [PMID: 22710060]
[http://dx.doi.org/10.1002/jcp.22408] [PMID: 20857424]
[http://dx.doi.org/10.1002/jcb.23042] [PMID: 21312238]
[http://dx.doi.org/10.1097/01.tp.0000259752.13304.0b] [PMID: 17452890]
[http://dx.doi.org/10.1080/08977190701345200] [PMID: 17852409]
[http://dx.doi.org/10.1634/stemcells.2005-0342] [PMID: 16410387]
[http://dx.doi.org/10.1016/j.yexcr.2005.04.029] [PMID: 15925364]
[http://dx.doi.org/10.1182/blood.V98.8.2396] [PMID: 11588036]
[http://dx.doi.org/10.1634/stemcells.2007-0554] [PMID: 17932417]
[http://dx.doi.org/10.1186/s12967-018-1400-3] [PMID: 29540180]
[http://dx.doi.org/10.1111/j.1432-0436.2004.07207003.x] [PMID: 15554943]
[http://dx.doi.org/10.1002/term.1575] [PMID: 22815264]
[http://dx.doi.org/10.1155/2017/2541275] [PMID: 28553357]
[http://dx.doi.org/10.1007/s10059-013-0112-z] [PMID: 23677376]
[http://dx.doi.org/10.1186/s40001-017-0258-9] [PMID: 28526089]
[http://dx.doi.org/10.1158/0008-5472.CAN-06-4024] [PMID: 17616689]
[http://dx.doi.org/10.1002/jcb.24852] [PMID: 24905804]
[http://dx.doi.org/10.1038/srep09596] [PMID: 25872464]
[http://dx.doi.org/10.2217/rme.14.72] [PMID: 25562354]
[http://dx.doi.org/10.20517/2347-9264.2016.74]
[http://dx.doi.org/10.1371/journal.pone.0127992] [PMID: 26061052]
[http://dx.doi.org/10.1097/SAP.0000000000000802] [PMID: 27070671]
[http://dx.doi.org/10.1080/14653240801891667] [PMID: 18368596]
[http://dx.doi.org/10.1016/j.exphem.2012.07.009] [PMID: 22846168]
[http://dx.doi.org/10.1634/stemcells.2004-0013] [PMID: 15579650]
[http://dx.doi.org/10.1016/j.cellbi.2007.08.002] [PMID: 17904875]
[http://dx.doi.org/10.3233/BME-2012-0714] [PMID: 22785368]
[http://dx.doi.org/10.1371/journal.pone.0122465] [PMID: 25848763]
[http://dx.doi.org/10.1007/s11010-014-2303-0] [PMID: 25555467]
[http://dx.doi.org/10.6026/97320630014053] [PMID: 29618900]
[http://dx.doi.org/10.3724/SP.J.1263.2011.12091] [PMID: 22916064]
[http://dx.doi.org/10.1016/j.cellimm.2012.06.010] [PMID: 23121974]
[http://dx.doi.org/10.3389/fonc.2018.00592] [PMID: 30581772]
[http://dx.doi.org/10.3892/ol.2019.10094] [PMID: 30944641]
[http://dx.doi.org/10.1089/ten.tea.2008.0579] [PMID: 19257811]
[http://dx.doi.org/10.1007/s13770-016-0013-2] [PMID: 30603454]
[http://dx.doi.org/10.1097/01.tp.0000173794.72151.88] [PMID: 16210973]
[http://dx.doi.org/10.1016/j.ejvs.2017.10.012] [PMID: 29208350]
[http://dx.doi.org/10.1631/jzus.2007.B0136] [PMID: 17266190]
[http://dx.doi.org/10.1016/j.cellbi.2006.03.009] [PMID: 16870478]
[http://dx.doi.org/10.1186/s13287-018-1105-9] [PMID: 30606242]
[http://dx.doi.org/10.1159/000080341] [PMID: 15319535]
[http://dx.doi.org/10.1186/1423-0127-18-59] [PMID: 21854621]
[http://dx.doi.org/10.3727/096368907783338190] [PMID: 18293895]
[http://dx.doi.org/10.1186/s13287-015-0078-1] [PMID: 25956259]
[http://dx.doi.org/10.1089/ten.tea.2012.0773] [PMID: 24251600]
[http://dx.doi.org/10.1007/s11427-007-0019-z] [PMID: 17609888]
[http://dx.doi.org/10.1186/ar2473] [PMID: 18691412]
[http://dx.doi.org/10.1089/ten.tec.2009.0208] [PMID: 19839740]
[http://dx.doi.org/10.1089/ten.tec.2012.0465] [PMID: 23126465]
[http://dx.doi.org/10.1016/j.lfs.2012.10.015] [PMID: 23123441]
[http://dx.doi.org/10.2174/1574888X11666160429122133] [PMID: 27133085]
[http://dx.doi.org/10.3727/096368912X655127] [PMID: 23068312]
[http://dx.doi.org/10.1161/01.RES.0000265074.83288.09] [PMID: 17495232]
[http://dx.doi.org/10.1016/j.vetimm.2011.06.033] [PMID: 21782255]
[http://dx.doi.org/10.1016/S0003-4975(02)03910-3] [PMID: 12400830]
[http://dx.doi.org/10.1016/j.ejcts.2003.12.038] [PMID: 15037283]
[http://dx.doi.org/10.1016/j.yexcr.2007.12.022] [PMID: 18325494]
[http://dx.doi.org/10.1002/jcp.20636] [PMID: 16557516]
[http://dx.doi.org/10.1089/scd.2008.0117] [PMID: 18597617]
[http://dx.doi.org/10.1016/j.scr.2012.04.001] [PMID: 22640926]
[http://dx.doi.org/10.1007/s00383-015-3808-7] [PMID: 26621500]
[http://dx.doi.org/10.1111/j.1432-0436.2006.00110.x] [PMID: 17244018]
[http://dx.doi.org/10.1038/s41598-018-29477-5] [PMID: 30054533]
[http://dx.doi.org/10.1371/journal.pone.0186238] [PMID: 29020119]
[http://dx.doi.org/10.3727/09638910X519265] [PMID: 21208530]
[http://dx.doi.org/10.1097/PRS.0b013e318221db33] [PMID: 21572381]
[http://dx.doi.org/10.1016/j.jcyt.2013.04.001] [PMID: 23725689]
[http://dx.doi.org/10.1371/journal.pone.0052997] [PMID: 23301012]
[PMID: 26722142]
[PMID: 25821294]
[http://dx.doi.org/10.1016/j.scr.2010.08.005] [PMID: 20880767]
[http://dx.doi.org/10.1155/2009/789526] [PMID: 20037738]
[http://dx.doi.org/10.1016/S1472-6483(10)60539-1] [PMID: 18062871]
[http://dx.doi.org/10.3892/ijmm.18.6.1089] [PMID: 17089012]
[http://dx.doi.org/10.3109/14653249.2012.684377] [PMID: 22587592]
[http://dx.doi.org/10.1002/jcb.25563] [PMID: 27038129]
[http://dx.doi.org/10.1159/000343740] [PMID: 23257615]
[http://dx.doi.org/10.1111/j.1365-3083.2009.02283.x] [PMID: 19630923]
[http://dx.doi.org/10.1634/stemcells.2004-0166] [PMID: 15671145]
[http://dx.doi.org/10.1371/journal.pone.0009016] [PMID: 20126406]
[http://dx.doi.org/10.1007/s12291-017-0641-x] [PMID: 29371769]
[http://dx.doi.org/10.1002/sctm.17-0133] [PMID: 29052365]
[http://dx.doi.org/10.1016/j.joca.2005.05.005] [PMID: 16129630]
[http://dx.doi.org/10.1002/jcp.28605] [PMID: 30963575]
[PMID: 27609477]
[http://dx.doi.org/10.1002/term.1515] [PMID: 22689330]
[http://dx.doi.org/10.1371/journal.pone.0032350] [PMID: 22615730]
[http://dx.doi.org/10.1089/ten.2006.12.2853] [PMID: 17518654]
[http://dx.doi.org/10.1089/scd.2013.0301] [PMID: 24172175]
[http://dx.doi.org/10.1186/1471-2164-15-910] [PMID: 25326687]
[http://dx.doi.org/10.1002/jcp.22062] [PMID: 20143331]
[http://dx.doi.org/10.1016/j.cellimm.2012.03.012] [PMID: 22546369]
[http://dx.doi.org/10.1634/stemcells.2007-1028] [PMID: 18703664]
[http://dx.doi.org/10.1186/s13006-019-0203-3] [PMID: 30792750]
[http://dx.doi.org/10.3109/09537101003602483] [PMID: 20187717]
[http://dx.doi.org/10.15283/ijsc.2014.7.2.118] [PMID: 25473449]
[http://dx.doi.org/10.1080/10667857.2018.1515300]
[http://dx.doi.org/10.3892/etm.2017.4069] [PMID: 28450938]
[http://dx.doi.org/10.1007/s12015-010-9147-0] [PMID: 20396979]
[http://dx.doi.org/10.1016/j.biomaterials.2007.11.026] [PMID: 18191190]
[http://dx.doi.org/10.1111/cei.12270] [PMID: 24666184]
[http://dx.doi.org/10.1002/jcp.25937] [PMID: 28369825]
[http://dx.doi.org/10.1089/hgtb.2018.191] [PMID: 30280937]
[http://dx.doi.org/10.4137/CTTT.S3654]
[http://dx.doi.org/10.1186/s40064-016-3712-1] [PMID: 27995034]
[http://dx.doi.org/10.1186/s13287-017-0755-3] [PMID: 29338788]
[http://dx.doi.org/10.4252/wjsc.v12.i4.288] [PMID: 32399137]
[http://dx.doi.org/10.1186/s13287-015-0013-5] [PMID: 25889741]
[http://dx.doi.org/10.1182/blood-2007-07-099622] [PMID: 18086871]
[http://dx.doi.org/10.1186/s13287-017-0491-8] [PMID: 28202061]
[http://dx.doi.org/10.1007/s10517-005-0430-z] [PMID: 16254640]
[http://dx.doi.org/10.1016/0165-2478(93)90058-A] [PMID: 7688713]
[PMID: 23114147]
[http://dx.doi.org/10.1016/j.jcyt.2013.04.009] [PMID: 23800730]
[http://dx.doi.org/10.1097/01.brs.0000193891.71672.e4] [PMID: 16395182]
[http://dx.doi.org/10.1634/stemcells.2005-0235] [PMID: 16410391]
[http://dx.doi.org/10.1371/journal.pone.0017834] [PMID: 21483855]
[http://dx.doi.org/10.1371/journal.pone.0113288] [PMID: 25412325]
[http://dx.doi.org/10.1007/s12010-012-9637-4] [PMID: 22391697]
[http://dx.doi.org/10.3389/fphar.2018.01175] [PMID: 30459600]
[http://dx.doi.org/10.1016/j.cellimm.2012.07.008] [PMID: 22982671]
[http://dx.doi.org/10.1016/j.imlet.2009.07.010] [PMID: 19647021]
[http://dx.doi.org/10.1371/journal.pone.0194847] [PMID: 29641603]
[http://dx.doi.org/10.1016/j.diff.2014.02.007] [PMID: 24713343]
[http://dx.doi.org/10.1634/stemcells.21-1-50] [PMID: 12529551]
[http://dx.doi.org/10.1016/j.rbmo.2010.04.010] [PMID: 20638335]
[http://dx.doi.org/10.1007/s00784-017-2073-7] [PMID: 28205023]
[http://dx.doi.org/10.1186/1471-2474-14-223] [PMID: 23898974]
[http://dx.doi.org/10.1016/j.biopha.2017.12.109] [PMID: 29625528]
[http://dx.doi.org/10.2147/IJN.S167880] [PMID: 30237713]
[http://dx.doi.org/10.1002/cyto.a.22402] [PMID: 24700575]
[http://dx.doi.org/10.1006/cyto.2000.0734] [PMID: 10976008]
[http://dx.doi.org/10.1038/s41598-020-61167-z] [PMID: 32152403]
[http://dx.doi.org/10.1002/cbin.10198] [PMID: 24155046]
[http://dx.doi.org/10.1159/000505238] [PMID: 32464631]
[http://dx.doi.org/10.18869/nrip.jamsat.3.2.77]
[http://dx.doi.org/10.1177/0890334413475528] [PMID: 23515086]
[http://dx.doi.org/10.3791/51225] [PMID: 24637893]
[PMID: 24674590]
[http://dx.doi.org/10.1002/stem.1585] [PMID: 24549637]
[http://dx.doi.org/10.1002/stem.1187] [PMID: 22865636]
[http://dx.doi.org/10.1007/978-1-59745-245-8_12]
[http://dx.doi.org/10.1016/j.jcyt.2012.11.010] [PMID: 23318344]
[http://dx.doi.org/10.1007/s11626-013-9688-z] [PMID: 24052474]
[http://dx.doi.org/10.1002/cbin.10171] [PMID: 24038753]
[http://dx.doi.org/10.1007/s11427-010-0009-4] [PMID: 20596940]
[http://dx.doi.org/10.1089/scd.2005.14.65] [PMID: 15725745]
[http://dx.doi.org/10.1007/s00277-012-1438-x] [PMID: 22395436]
[http://dx.doi.org/10.5152/iao.2016.1190] [PMID: 27340981]
[http://dx.doi.org/10.1016/j.brainresbull.2010.12.013] [PMID: 21194558]
[http://dx.doi.org/10.1177/1933719113488443] [PMID: 23670950]
[http://dx.doi.org/10.1007/s12035-015-9199-x] [PMID: 26001761]
[http://dx.doi.org/10.4103/1673-5374.211189] [PMID: 28852392]
[http://dx.doi.org/10.1155/2016/9291013]
[http://dx.doi.org/10.4103/1673-5374.162768] [PMID: 26487861]
[http://dx.doi.org/10.1007/s11626-015-9921-z] [PMID: 26148883]
[http://dx.doi.org/10.1007/s11064-009-9992-x] [PMID: 19462232]
[http://dx.doi.org/10.1089/ten.tea.2008.0393] [PMID: 19260778]
[http://dx.doi.org/10.1016/j.biomaterials.2006.03.017] [PMID: 16569429]
[http://dx.doi.org/10.1016/j.diff.2009.09.002] [PMID: 19800163]
[http://dx.doi.org/10.1155/2018/7131532] [PMID: 30651734]
[http://dx.doi.org/10.1186/s13287-015-0066-5] [PMID: 25884704]
[http://dx.doi.org/10.1186/scrt232] [PMID: 23845279]
[http://dx.doi.org/10.2174/1875043501104010072]
[http://dx.doi.org/10.1016/j.eats.2017.08.055] [PMID: 29552470]
[http://dx.doi.org/10.18388/abp.2016_1488] [PMID: 28600911]
[http://dx.doi.org/10.1155/2018/2406462] [PMID: 30534156]
[PMID: 20052672]
[http://dx.doi.org/10.1186/s13287-017-0501-x] [PMID: 28320452]
[http://dx.doi.org/10.3892/etm.2017.5249] [PMID: 29285060]
[http://dx.doi.org/10.1186/s40001-014-0080-6] [PMID: 25644284]
[http://dx.doi.org/10.1186/s13287-017-0700-5] [PMID: 29096715]
[http://dx.doi.org/10.1182/blood-2004-09-3645] [PMID: 15755902]
[http://dx.doi.org/10.1177/153537020422900706] [PMID: 15229356]
[http://dx.doi.org/10.1016/j.yjmcc.2006.07.002] [PMID: 16919679]
[http://dx.doi.org/10.1510/icvts.2007.157875] [PMID: 17670726]
[http://dx.doi.org/10.3892/mmr.2014.2935] [PMID: 25395242]
[http://dx.doi.org/10.1111/exd.12406] [PMID: 24689514]
[http://dx.doi.org/10.1155/2018/8947548] [PMID: 29765427]
[http://dx.doi.org/10.1590/1678-4162-9132]
[http://dx.doi.org/10.4103/1735-3327.113341] [PMID: 23946735]
[PMID: 25489516]
[http://dx.doi.org/10.1111/j.1582-4934.2010.01009.x] [PMID: 20070436]
[http://dx.doi.org/10.1007/s12015-010-9196-4] [PMID: 20972649]
[http://dx.doi.org/10.1016/j.diff.2009.01.001] [PMID: 19505629]
[http://dx.doi.org/10.1186/s13287-019-1396-5] [PMID: 31547868]
[http://dx.doi.org/10.3748/wjg.v12.i36.5834] [PMID: 17007050]
[http://dx.doi.org/10.1016/j.bbrc.2006.01.072] [PMID: 16460677]
[http://dx.doi.org/10.1002/cbin.10278] [PMID: 24687540]
[http://dx.doi.org/10.1186/s13287-020-1555-8] [PMID: 32033595]
[PMID: 30595825]
[PMID: 31875078]
[PMID: 26306150]
[PMID: 26328041]
[PMID: 26662137]
[http://dx.doi.org/10.3390/ijms20123016] [PMID: 31226809]
[http://dx.doi.org/10.15283/ijsc17003] [PMID: 29084421]
[http://dx.doi.org/10.1007/s13770-017-0048-z] [PMID: 30603500]
[http://dx.doi.org/10.31616/asj.2019.0026] [PMID: 31711062]