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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

General Review Article

An Overview of Nano Delivery Systems for Targeting RNA Interference-based Therapy in Ulcerative Colitis

Author(s): Iman M. Alfagih*, Basmah N. Aldosari , Bushra T. AlQuadeib , Alanood S. Almurshedi and Murtaza M. Tambuwala*

Volume 27 , Issue 25 , 2021

Published on: 26 August, 2021

Page: [2904 - 2914] Pages: 11

DOI: 10.2174/1381612827666210617120302

Price: $65

Abstract

Ulcerative colitis (UC) is one of the main subtypes of inflammatory bowel disease. UC has a negative effect on patients’ quality of life, and it is an important risk factor for the development of colitis-associated cancer. Patients with UC need to take medications for their entire life because no permanent cure is available. Therefore, approaches that target messenger RNA (mRNA) of proinflammatory cytokines and/or anti-inflammatory cytokines are needed to improve the safety of UC therapy and promote intestinal mucosa recovery. The major challenge facing RNA interference-based therapy is the delivery of RNA molecules to the intracellular space of target cells. Moreover, nonspecific and systemic protein expression inhibition can result in adverse effects and low therapeutic benefit. Thus, it is important to develop an efficient delivery strategy targeting the cytoplasm of target cells to avoid side effects caused by off-target protein expression inhibition. This review focuses on the most recent advances in the targeted nano delivery systems of siRNAs and mRNA that have shown in vivo efficacy.

Keywords: RNA interference, nanoparticles, targeted delivery, surface functionalization, inflammation, ulcerative colitis.


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