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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer

Author(s): Xing Fei Tan, Qifan Chen, San Hue Hua and George Wai Yip*

Volume 28, Issue 25, 2021

Published on: 09 July, 2021

Page: [5034 - 5047] Pages: 14

DOI: 10.2174/0929867328666210617105209

Price: $65


The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.

Keywords: Cancer, interferon-induced protein, tetratricopeptide repeats, IFIT, biomarker, prognostic factor.

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