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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Mini-Review Article

Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer

Author(s): Rakesh Sahu*, Rakhi Mishra, Rajnish Kumar, Salahuddin, Chandana Majee, Avijit Mazumder and Ajay Kumar

Volume 22, Issue 2, 2022

Published on: 14 June, 2021

Page: [248 - 272] Pages: 25

DOI: 10.2174/1389557521666210614162031

Price: $65

Abstract

Abstract: The incidence of cancer is increasing worldwide, affecting a vast majority of the human population, therefore, new different anticancer agents are being developed now and their safety still needs to be evaluated. Among them, pyridine based drugs are contributing a lot, as they are one of the imperative pharmacophores occurring synthetically as well as naturally in heterocyclic compounds, having a wide-range of therapeutic applications in the area of drug discovery that offers many chances for further improvement in antitumor agents via acting onto numerous receptors of extreme prominence. Many pyridine derivatives are reported to inhibit enzymes, receptors and many other targets for controlling and curing the global health issue of cancer. Nowadays in combination with other moieties, researchers are focusing on the development of pyridine-based new derivatives for cancer treatment. Therefore, this review sheds light on the recent therapeutic expansion of pyridine together with its molecular docking, structure-activity-relationship, availability in the market, a summary of recently patented and published research works that shall jointly help the scientists to produce effective drugs with the desired pharmacological activity.

Keywords: Pyridine moiety, anticancer, heterocyclic compound, structure-activity relationships (SAR), cancer treatment, WHO.

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