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Current Aging Science

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ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

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Research Article

Development and Evaluation of a Low-cost Dairy Food Supplement with Mauritia Flexuosa (Buriti) to Combat Malnutrition: Translational Study in Mice and Institutionalized Elderly Woman

Author(s): Audrey Handyara Bicalho, Fabio Ribeiro Santos, Daniele Cristina Moreira, Victor Hugo Dantas Guimarães, Guilherme Henrique Ribeiro, Alfredo Mauricio Batista De Paula, André Luis Sena Guimarães, Ulisses A. Pereira, Theles Costa, Caroline Liboreiro Paiva, Marcelo Perim Baldo and Sérgio Henrique Sousa Santos*

Volume 15, Issue 1, 2022

Published on: 14 June, 2021

Page: [37 - 48] Pages: 12

DOI: 10.2174/1874609814666210614104904

Price: $65

Abstract

Aims: The present study aimed to develop and evaluate a new dairy by-product nutritional supplement with Buriti fruit to improve malnutrition in mice and elderly woman.

Background: Malnutrition is a prevalent problem in the elderly; therefore, oral dietary supplementation is an important strategy to reduce this health problem incidence.

Objective: The present study evaluated the effects of a low-cost food supplement, made from byproducts of the dairy and fruit industry in the Brazilian Cerrado (Buriti), on the nutritional status and on the recovery of the metabolic profile of malnourished animals and elderly women.

Methods: In the pre-clinical phase, Swiss mice were divided into six groups and subjected to malnutrition and renutrition. The clinical phase was carried out with 25 elderly women residing in a long-term institution, aged ≥ 65 years and with malnutrition or risk of malnutrition.

Results: The main results showed improvements in anthropometric parameters and an increase in serum albumin levels, in addition to lipid profile improvement in the preclinical phase and an increase in the red blood cells and hemoglobin in the clinical phase.

Conclusion: The supplement based on Buriti was able to reverse malnutrition promoting improvements in anthropometric and biochemical parameters.

Keywords: Aging, malnutrition, oral nutritional supplement, Mauritia flexuosa L. f, Buriti, Cerrado, Savanna.

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[1]
Donini LM, Scardella P, Piombo L, et al. Malnutrition in elderly: social and economic determinants. J Nutr Health Aging 2013; 17(1): 9-15.
[http://dx.doi.org/10.1007/s12603-012-0374-8] [PMID: 23299371]
[2]
Guigoz Y. The Mini Nutritional Assessment (MNA) review of the literature--What does it tell us? J Nutr Health Aging 2006; 10(6): 466-85.
[PMID: 17183419]
[3]
Pereira Machado RS, Santa Cruz Coelho MA. Risk of malnutrition among Brazilian institutionalized elderly: a study with the Mini Nutritional Assessment (MNA) questionnaire. J Nutr Health Aging 2011; 15(7): 532-5.
[http://dx.doi.org/10.1007/s12603-011-0059-8] [PMID: 21808930]
[4]
Gammack JK, Sanford AM. Caloric supplements for the elderly. Curr Opin Clin Nutr Metab Care 2015; 18(1): 32-6.
[http://dx.doi.org/10.1097/MCO.0000000000000125] [PMID: 25474011]
[5]
Agarwal E, Miller M, Yaxley A, Isenring E. Malnutrition in the elderly: a narrative review. Maturitas 2013; 76(4): 296-302.
[http://dx.doi.org/10.1016/j.maturitas.2013.07.013] [PMID: 23958435]
[6]
Lee L-C, Tsai AC, Wang J-Y, Hurng B-S, Hsu H-C, Tsai H-J. Need-based intervention is an effective strategy for improving the nutritional status of older people living in a nursing home: a randomized controlled trial. Int J Nurs Stud 2013; 50(12): 1580-8.
[http://dx.doi.org/10.1016/j.ijnurstu.2013.04.004] [PMID: 23648392]
[7]
de Campos Horvat Borrego C, dos Santos Cantaria J . Efeito da utilização de complemento alimentar em idosos atendidos em um ambulatório na cidade de São Paulo. Rev Bras Geriatr Gerontol 2013; 16(2): 295-302.
[http://dx.doi.org/10.1590/S1809-98232013000200009]
[8]
Silva MR, Lacerda DBCL, Santos GG, Martins DM de O. Caracterização química de frutos nativos do cerrado. Cienc Rural 2008; 38(6): 1790-3.
[http://dx.doi.org/10.1590/S0103-84782008000600051]
[9]
Lage NN, Lopes JMM, Pereira RR, Da Costa Guerra JF. Antioxidant potential of Buriti (Mauritia exuosa) pulp our in diabetic rats. Arch Latinoam Nutr 2018; 68(1) Available from: https://www. alanrevista.org/ediciones/2018/1/art-6/
[10]
Mariath JGR, Lima MCC, Santos LMP. Vitamin A activity of buriti (Mauritia vinifera Mart) and its effectiveness in the treatment and prevention of xerophthalmia. Am J Clin Nutr 1989; 49(5): 849-53.
[http://dx.doi.org/10.1093/ajcn/49.5.849] [PMID: 2718919]
[11]
Resende LM, Franca AS, Oliveira LS. Buriti (Mauritia flexuosa L. f.) fruit by-products flours: Evaluation as source of dietary fibers and natural antioxidants. Food Chem 2019; 270: 53-60.
[http://dx.doi.org/10.1016/j.foodchem.2018.07.079]
[12]
Pennings B, Boirie Y, Senden JMG, Gijsen AP, Kuipers H, van Loon LJ. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 2011; 93(5): 997-1005.
[http://dx.doi.org/10.3945/ajcn.110.008102] [PMID: 21367943]
[13]
Devries MC, Phillips SM. Supplemental protein in support of muscle mass and health: advantage whey. J Food Sci 2015; 80(S1): A8-A15.
[http://dx.doi.org/10.1111/1750-3841.12802] [PMID: 25757896]
[14]
Davoodi SH, Shahbazi R, Esmaeili S, et al. Health-related aspects of milk proteins. Iran J Pharm Res 2016; 15(3): 573-91.
[PMID: 27980594]
[15]
Patel S. Emerging trends in nutraceutical applications of whey protein and its derivatives. J Food Sci Technol 2015; 52(11): 6847-58. http://link.springer.com/10.1007/s13197-015-1894-0
[http://dx.doi.org/10.1007/s13197-015-1894-0] [PMID: 26884639]
[16]
Bicalho AH, do Santos FR, Moreira DC, et al. Liver Damage Produced by Malnutrition is Improved by Dietary Supplementation in Mice: Assessment of a Supplement Based on Buriti (A Cerrado Fruit) and Dairy By-products. Recent Pat Food Nutr Agric 2021; 12(1): 29-35.
[http://dx.doi.org/10.2174/2212798411999210101224626] [PMID: 33397263]
[17]
Fock RA, Vinolo MAR, de Moura Sá Rocha V, de Sá Rocha LC, Borelli P. Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-α in response to lipopolysaccharide (LPS) in mice. Cytokine 2007; 40(2): 105-14.
[http://dx.doi.org/10.1016/j.cyto.2007.08.007] [PMID: 17950615]
[18]
Jelliffe DB. The assessment of the nutritional status of the community (with special reference to field surveys in developing regions of the world). Monogr Ser World Health Organ 1966; 53: 3-271.
[PMID: 4960818]
[19]
Chumlea WC, Roche AF, Steinbaugh ML. Estimating stature from knee height for persons 60 to 90 years of age. J Am Geriatr Soc 1985; 33(2): 116-20.
[http://dx.doi.org/10.1111/j.1532-5415.1985.tb02276.x] [PMID: 3968366]
[20]
Chumlea WC, Guo S, Roche AF, Steinbaugh ML. Prediction of body weight for the nonambulatory elderly from anthropometry. J Am Diet Assoc 1988; 88(5): 564-8.
[PMID: 3367012]
[21]
van Asselt DZB, van Bokhorst-de van der Schueren MAE, van der Cammen TJM, et al. Assessment and treatment of malnutrition in Dutch geriatric practice: Consensus through a modified Delphi study. Age Ageing 2012; 41(3): 399-404.
[http://dx.doi.org/10.1093/ageing/afs005] [PMID: 22334385]
[22]
Kim S-K, Kwon Y-H, Cho JH, et al. Changes in body composition according to age and sex among young non-diabetic korean adults: The kangbuk samsung health study. Endocrinol Metab (Seoul) 2017; 32(4): 442-50.
[http://dx.doi.org/10.3803/EnM.2017.32.4.442] [PMID: 29199402]
[23]
Lauque S, Arnaud-Battandier F, Mansourian R, et al. Protein-energy oral supplementation in malnourished nursing-home residents. A controlled trial. Age Ageing 2000; 29(1): 51-6.
[http://dx.doi.org/10.1093/ageing/29.1.51] [PMID: 10690696]
[24]
Clegg ME, Williams EA. Optimizing nutrition in older people. Maturitas 2018; 112: 34-8.
[http://dx.doi.org/10.1016/j.maturitas.2018.04.001] [PMID: 29704915]
[25]
Pereira MLAS, de Almeida Moreira P, De Oliveira CC, et al. Estado nutricional de ancianos brasileños institucionalizados: Un estudio con el mini nutritional assessment. Nutr Hosp 2015; 31(3): 1198-204.
[26]
Sampaio LR. Avaliação nutricional e envelhecimento. Rev Nutr 2004; 17(4): 507-14.
[http://dx.doi.org/10.1590/S1415-52732004000400010]
[27]
Siparsky PN, Kirkendall DT, Garrett WE. Muscle changes in aging. Sport heal a multidiscip approach 2014; 6(1): 36-40.
[http://dx.doi.org/10.1177/1941738113502296]
[28]
Kokkinidou S, Peterson D, Bloch T, Bronston A. The important role of carbohydrates in the flavor, function, and formulation of oral nutritional supplements. Nutrients 2018; 10(6): 742.
[http://dx.doi.org/10.3390/nu10060742] [PMID: 29890616]
[29]
Milne AC, Potter J, Vivanti A, Avenell A. Protein and energy supplementation in elderly people at risk frommalnutrition. Cochrane Database Syst Rev 2009; 2: CD003288.
[http://dx.doi.org/10.1002/14651858.CD003288.pub3]
[30]
Caselato-Sousa VM, Guariento ME, Crosta G, Pinto MA da S, Sgarbieri VC. Using the Mini Nutritional Assessment to Evaluate the Profile of Elderly Patients in a Geriatric Outpatient Clinic and in Long-Term Institutions. Int J Clin Med 2011; 02(05): 582-7.
[http://dx.doi.org/10.4236/ijcm.2011.25096]
[31]
Ordóñez J, De Antonio Veira JA, Pou Soler C, et al. Efecto de un suplemento nutricional oral hiperproteico en pacientes desnutridos ubicados en residencias geriátricas. Nutr Hosp 2010; 25(4): 549-54.
[PMID: 20694290]
[32]
Sampaio MB, Carrazza LR. Manual tecnológico de aproveitamento integral do fruto e da folha do Buriti (Mauritia flexuosa). Instituto Sociedade, População e Natureza (ISPN) 2012; 75. Available from: http://www.bibliotecadigital.abong.org.br/ bitstream/handle/11465/301/ISPN_manual_tecnologico_aproveitamento_integral_do_fruto_buriti.pdf?sequence=1
[33]
Iuliano S, Poon S, Wang X, Bui M, Seeman E. Dairy food supplementation may reduce malnutrition risk in institutionalised elderly. Br J Nutr 2017; 117(1): 142-7.
[http://dx.doi.org/10.1017/S000711451600461X] [PMID: 28098050]
[34]
Camargo LDR, Doneda D, Oliveira VR. Whey protein ingestion in elderly diet and the association with physical, performance and clinical outcomes. Exp Gerontol 2020; 137: 110936.
[http://dx.doi.org/10.1016/j.exger.2020.110936] [PMID: 32289487]
[35]
Bauer JM, Diekmann R. Protein supplementation with aging. Curr Opin Clin Nutr Metab Care 2015; 18(1): 24-31.
[http://dx.doi.org/10.1097/MCO.0000000000000124] [PMID: 25474010]
[36]
Katsanos CS, Chinkes DL, Paddon-Jones D, Zhang XJ, Aarsland A, Wolfe RR. Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res 2008; 28(10): 651-8.
[http://dx.doi.org/10.1016/j.nutres.2008.06.007] [PMID: 19083472]
[37]
Mosoni L, Gatineau E, Gatellier P, et al. High whey protein intake delayed the loss of lean body mass in healthy old rats, whereas protein type and polyphenol/antioxidant supplementation had no effects. In: Johannsen D, Ed. PLoS One 2014; 9(9): e109098. Available from: https://dx.plos.org/10.1371/journal.pone.0109098

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