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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Potential Use of Pharmacological Cyclin-Dependent Kinase Inhibitors as Anti-HIV Therapeutics

Author(s): Anne Pumfery, Cynthia d. l. Fuente, Reem Berro, Sergei Nekhai, Fatah Kashanchi and Sheng-Hao Chao

Volume 12, Issue 16, 2006

Page: [1949 - 1961] Pages: 13

DOI: 10.2174/138161206777442083

Price: $65


Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II transcription. Several pharmacological CDK inhibitors (PCIs) are currently in clinical trials as potential cancer therapeutics since CDK hyperactivation is detected in the majority of neoplasias. Within the last few years, the anti-viral effects of PCIs have also been observed against various viruses, including human immunodeficiency virus (HIV), herpes simplex virus, and murine leukemia virus. Through the inhibition of CDK2 and 9, the cellular co-factors for HIV-1 Tat transactivation, HIV-1 replication is blocked by two specific PCIs, CYC202 and flavopiridol, respectively. In this article, we will review the inhibitory mechanisms of flavopiridol and CYC202 and discuss their possible usage in AIDS treatment.

Keywords: Flavopiridol, roscovitine, CYC202, P-TEFb, CDK9, CDK2, HIV, Tat

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